Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Phil Olsen"'
Publikováno v:
Tetrahedron Letters. 58:1050-1052
Herein, we describe the isolation and characterization of a UnyLinker dimer which, if left uncontrolled, can become incorporated in oligonucleotide products. The dimer is formed as a result of an unusual intermolecular osmium-catalyzed etherification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acdd7f915b5863cc637bf797353fd346
https://doi.org/10.1016/j.tetlet.2017.01.101
https://doi.org/10.1016/j.tetlet.2017.01.101
Autor:
Phil Olsen, R. Krishna Kumar, Lucio Mendez, Anthony N. Scozzari, Max N. Moore, Zhiwei Wang, Recaldo L. Carty, Vasulinga T. Ravikumar, Isaiah Cedillo, Ratnasamy Somanathan, Xue-Feng Zhu, Mark Andrade, Gerardo Aguirre, Dennis Gorman, Sylvain Berneès
Publikováno v:
Organic Process Research & Development. 12:399-410
A novel universal linker (UnyLinker) molecule which has a conformationally rigid and chemically stable bridge head ring oxygen atom carrying a conventional 4,4′-dimethoxytrityl (DMT) and succinyl groups locked in a syn orientation has been develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61eba3b555143a18b1ed64c45af03ba5
https://doi.org/10.1021/op8000178
https://doi.org/10.1021/op8000178
Autor:
Phil Olsen, Dennis Gorman, Achim H. Krotz, Hans Gaus, Anthony N. Scozzari, Claus Rentel, James V. McArdle
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 23:767-775
The impuritiy profiles of acetonitrile solutions of the four standard O-cyanoethyl-N,N-diisopropyl-phosphoramidites of 5'-O-dimethoxytrityl (DMT) protected deoxyribonucleosides (dG(ib), dA(bz), dC(bz), T) were analyzed by HPLC-MS. The solution stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bfc73c731a8a91b0cd0482107ba9f0
https://doi.org/10.1081/ncn-120039215
https://doi.org/10.1081/ncn-120039215
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 26(3)
A versatile and conformationally preorganized universal linker molecule is reported here for efficient synthesis of phosphorothioate oligonucleotides. With respect to nucleoside loaded support, comparable yield and quality based on ion-pair LC-MS are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7b07a3426e31c33f5b280241caa66e
https://pubmed.ncbi.nlm.nih.gov/17454735
https://pubmed.ncbi.nlm.nih.gov/17454735
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 26(2)
Phosphorothioate oligonucleotides could be synthesized using a 0.2 M solution of phenylacetyl disulfide (PADS) in a mixture of pyridine and acetonitrile (1:1, v/v) with >99.9% step-wise efficiency. Unlike most other sulfurizing reagents that need to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f0d07b187f121525c7f767c57fc3aa
https://pubmed.ncbi.nlm.nih.gov/17365796
https://pubmed.ncbi.nlm.nih.gov/17365796
Publikováno v:
Bioorganicmedicinal chemistry. 14(14)
Multiple 2'-O-methoxyethyl modified phosphorothioate oligonucleotides of 18-20-mer in length were synthesized at various scales using 4,5-dicyanoimidazole (DCI) as coupling activator. Extensive synthetic, analytical (using ion-pair LC-MS), and in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b319084ec3248993afc866fc0fc6c64c
https://pubmed.ncbi.nlm.nih.gov/16563772
https://pubmed.ncbi.nlm.nih.gov/16563772
Autor:
Hans Gaus, Kathleen L. Walker, Phil Olsen, Daniel C. Capaldi, Kent Van Sooy, Brett Turney, James V. McArdle, Claus Rentel
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(18)
Some commercial batches of dichloroacetic acid (DCA) contain traces of chloral (trichloroacetaldehyde). Using such DCA to effect detritylation during solid-phase oligonucleotide synthesis results in the formation of a family of process impurities in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462dc6c983609b09b6af068d841a8cc6
https://pubmed.ncbi.nlm.nih.gov/16002284
https://pubmed.ncbi.nlm.nih.gov/16002284
Autor:
Vasulinga T. Ravikumar, Ratnasamy Somanathan, R. Krishna Kumar, Phil Olsen, Max N. Moore, Recaldo L. Carty, Mark Andrade, Dennis Gorman, Xuefeng Zhu, Isaiah Cedillo, Zhiwei Wang, Lucio Mendez, Anthony N. Scozzari, Gerardo Aguirre, Sylvain Berneès
Publikováno v:
Organic Process Research & Development; Apr2008, Vol. 12 Issue 3, p399-410, 12p