Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Phil L'Huillier"'
Autor:
David Scott, Phil L'Huillier, Garth J. S. Cooper, Ric Broadhurst, Chathurini Fernando, S. Reddy, Gordana Prijic, Shaoping Zhang, Kerry M. Loomes, Anthony R. J. Phillips, Jacqueline F. Aitken
Publikováno v:
Diabetes
OBJECTIVE Aggregation of human amylin/islet amyloid polypeptide (hA/hIAPP) into small soluble β-sheet–containing oligomers is linked to islet β-cell degeneration and the pathogenesis of type 2 diabetes. Here, we used tetracycline, which modifies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d53e6eafe7993bfa716b641deaf2dbc
https://doi.org/10.2337/db09-0548
https://doi.org/10.2337/db09-0548
Autor:
Ric Broadhurst, Peter L. Pfeffer, Helen W. Davey, Martyn Donnison, Phil L'Huillier, Angela Beaton
Publikováno v:
Development. 132:2299-2308
The extraembryonic ectoderm (ExE) is essential for mammalian placental formation and survival of the embryo in utero. We have obtained a mouse model lacking the ExE, by targeted deletion of the transcription factor Elf5. Although Elf5 mutant embryos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3315539806fbd8f1fdb207cebf17b23a
https://doi.org/10.1242/dev.01819
https://doi.org/10.1242/dev.01819
Autor:
Phil L'Huillier, David N. Wells, Thomas T. Wheeler, Grant Smolenski, Götz Laible, Brigid Brophy
Publikováno v:
Nature Biotechnology. 21:157-162
To enhance milk composition and milk processing efficiency by increasing the casein concentration in milk, we have introduced additional copies of the genes encoding bovine beta- and kappa-casein (CSN2 and CSN3, respectively) into female bovine fibro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b18c481ef71b3497daea4c27683e21
https://doi.org/10.1038/nbt783
https://doi.org/10.1038/nbt783
Autor:
S.-A. Turner, Robert D. McLaren, Peter C. Molan, Phil L'Huillier, Colin G. Prosser, Brett Langley, Martin J. Auldist
Publikováno v:
Journal of Dairy Research. 67:287-293
Two common genetic variants of β-lactoglobulin (β-lg), A and B, exist as co- dominant alleles in dairy cattle (Aschaffenburg, 1968). Numerous studies have shown that cows homozygous for β-lg A have more β-lg and less α-lactalbumin (α-la) and ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbf107e3bff49416de43a0ce3135d46
https://doi.org/10.1017/s002202990000409x
https://doi.org/10.1017/s002202990000409x
Autor:
Jacqueline Paly, Phil L'Huillier, Laurence Lepourry, Marie-Georges Stinnakre, Solange Soulier, Jean-Claude Mercier, Jean Djiane, Brett Langley, Jean-Luc Vilotte
Publikováno v:
Transgenic Research. 8:23-31
In order to establish a possible correlation between in vitro prolactin induction and the transcriptional activity of mammary gene promoters in transgenic mice, a functional Stat5-binding site was created by means of site-directed mutagenesis at posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8294f0f68d026252e45f2181582240
https://doi.org/10.1023/a:1008851802022
https://doi.org/10.1023/a:1008851802022
Autor:
Christopher Bruce Alexander Whitelaw, Brett Langley, Jean-Luc Vilotte, Phil L'Huillier, Marie-Georges Stinnakre
Publikováno v:
Transgenic Research. 7:205-212
In an attempt to enhance the frequency and level of expression of a poor-performing MMTV-driven transgene, we co-integrated this construct with the ovine beta-lactoglobulin (BLG) gene in transgenic mice. Seven lines of transgenic mice possessing co-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::053d163d421a1fe07d09c715fccee3fd
https://doi.org/10.1023/a:1008893030461
https://doi.org/10.1023/a:1008893030461
Publikováno v:
Animal reproduction science. 91(1-2)
The present study investigated whether protamine sulfate can be used to improve the efficiency of bovine sperm mediated transgenesis (SMT) by protecting the plasmid pCX-EGFP against nuclease activity. A high proportion (31%) of bovine spermatozoa tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd934f7552ebc4fe8b8cb8cf3685dc1
https://pubmed.ncbi.nlm.nih.gov/15899559
https://pubmed.ncbi.nlm.nih.gov/15899559
Autor:
Phil L'Huillier, A.L. Miller, Götz Laible, F.C. Tucker, M. C. Berg, J.T. Forsyth, K. Cockrem, J. E. Oliver, H.R. Tervit, David N. Wells, Björn Oback, T Xiang
Publikováno v:
Theriogenology. 59(1)
Several studies have shown that both quiescent and proliferating somatic donor cells can be fully reprogrammed after nuclear transfer (NT) and result in viable offspring. So far, however, no comparative study has conclusively demonstrated the relativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48218090b9576fa939990600cba899bc
https://pubmed.ncbi.nlm.nih.gov/12499017
https://pubmed.ncbi.nlm.nih.gov/12499017