Výsledky vyhledávání - "Phil J. Cowen"

PAX-D: study protocol for a randomised placebo-controlled trial evaluating the efficacy and mechanism of pramipexole as add-on treatment for people with treatment resistant depression

Publikováno v: Au-Yeung, S K, Griffiths, J, Roberts, S, Edwards, C, Yu, L-M, Bogacz, R, Rendell, J, Attenburrow, M-J, Watson, S, Chan, F, Cipriani, A, Cleare, A, Harmer, C J, Kessler, D, Evans, J, Lewis, G, Singh, I, Simon, J, Harrison, P J, Cowen, P, Shanyinde, M, Geddes, J & Browning, M 2021, ' PAX-D : study protocol for a randomised placebo-controlled trial evaluating the efficacy and mechanism of pramipexole as add-on treatment for people with treatment resistant depression ', Evidence-Based Mental Health . https://doi.org/10.1136/ebmental-2021-300282

IntroductionClinical depression is usually treated in primary care with psychological therapies and antidepressant medication. However, when patients do not respond to at least two or more antidepressants within a depressive episode, they are conside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58fa59b5fd180da47bfbaa524425ede
https://doi.org/10.1136/ebmental-2021-300282

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Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression

Autor: Athina R Aruldass, J. Cavanagh, Edward T. Bullmore, Phil J. Cowen, Carmine M. Pariante, Neil A Harrison, Sol Lim, Sarah E. Morgan, Alzheimer’s Disease, Petra E. Vértes, Manfred G. Kitzbichler, Mary-Ellen Lynall, Lorinda Turner

Publikováno v: Brain, Behavior, and Immunity. 98:299-309

ObjectiveThere is increasing evidence for a subgroup of major depressive disorder (MDD) associated with heightened peripheral blood inflammatory markers. In this study, the authors sought to understand the mechanistic brainimmune axis in inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00829041f110c35e63a4dee1e65b0675
https://doi.org/10.1016/j.bbi.2021.08.226

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Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression

Autor: Nicola Filippini, Catherine J. Harmer, Rob D. Chapman, Anthony A. James, Phil J. Cowen, Lucy Wright, Susannah E. Murphy, Liliana Capitão

Publikováno v: Journal of Psychopharmacology (Oxford, England)

Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the effects of a single dose of flu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be40031374d82d4c4489bf7aaa28c7dc
https://doi.org/10.1177/0269881120959608

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Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis

Autor: Franco De Crescenzo, Gian Loreto D'Alò, Edoardo G Ostinelli, Marco Ciabattini, Valeria Di Franco, Norio Watanabe, Ayse Kurtulmus, Anneka Tomlinson, Zuzana Mitrova, Francesca Foti, Cinzia Del Giovane, Digby J Quested, Phil J Cowen, Corrado Barbui, Laura Amato, Orestis Efthimiou, Andrea Cipriani

Publikováno v: De Crescenzo, Franco; D'Alò, Gian Loreto; Ostinelli, Edoardo G; Ciabattini, Marco; Di Franco, Valeria; Watanabe, Norio; Kurtulmus, Ayse; Tomlinson, Anneka; Mitrova, Zuzana; Foti, Francesca; Del Giovane, Cinzia; Quested, Digby J; Cowen, Phil J; Barbui, Corrado; Amato, Laura; Efthimiou, Orestis; Cipriani, Andrea (2022). Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis. Lancet, 400(10347), pp. 170-184. Elsevier 10.1016/S0140-6736(22)00878-9

BACKGROUND Behavioural, cognitive, and pharmacological interventions can all be effective for insomnia. However, because of inadequate resources, medications are more frequently used worldwide. We aimed to estimate the comparative effectiveness of ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9992d8510c7f6c54c707a8efef553c20
https://hdl.handle.net/11380/1288245

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Akademický článek

Lithium prescribing during pregnancy: a UK primary care database study.

Autor: Rachel L McCrea, Irwin Nazareth, Stephen J W Evans, David P J Osborn, Vanessa Pinfold, Phil J Cowen, Irene Petersen

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121024 (2015)

BackgroundWomen taking lithium must decide whether to continue the medication if they conceive or plan to conceive. Little is known about the extent of prescribing of lithium during pregnancy.AimsTo determine: 1) the prevalence of lithium prescribing

Externí odkaz: https://doaj.org/article/b53cc6e99e664ea197e07805660952ac

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Lithium modulates striatal reward anticipation and prediction error coding in healthy volunteers

Autor: Phil J. Cowen, Catherine J. Harmer, Lennart Verhagen, A. Pringle, Michael Browning, Inge Volman

Publikováno v: Neuropsychopharmacology, 46, 386-393
Neuropsychopharmacology, 46, 2, pp. 386-393
Neuropsychopharmacology

Contains fulltext : 226107.pdf (Publisher’s version ) (Closed access) Lithium is one of the most effective mood-stabilizing medications in bipolar disorder. This study was designed to test whether lithium administration may stabilize mood via effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d860ff40ab711ab571a6bb13d0927310
http://hdl.handle.net/2066/226107

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Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks

Autor: Neil A. Harrison, Athina R Aruldass, Nicholas G. Dowell, Linda Pointon, Tobias C. Wood, Jonathan Cavanagh, Edward T. Bullmore, Phil J. Cowen, John McLean, Manfred G. Kitzbichler, Marta M Correia, Charlotte Clarke, Gareth J. Barker, Mara Cercignani, Samuel A. Hurley, Carmine M. Pariante

Publikováno v: Molecular psychiatry. 26(12)

Inflammation is associated with depressive symptoms and innate immune mechanisms are likely causal in some cases of major depression. Systemic inflammation also perturbs brain function and microstructure, though how these are related remains unclear.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0a6eee6f88a7a9c166c71647c66817
https://pubmed.ncbi.nlm.nih.gov/34535766

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Revisiting monoamine oxidase inhibitors for the treatment of depressive disorders: A systematic review and network meta-analysis

Autor: Omar F. Pinjari, Vaishali Tirumalaraju, Sudhakar Selvaraj, Jair C. Soares, Jacob Aickareth, Constanza de Dios, Phil J. Cowen, Taya Bockmann, Robert Suchting, Rida Gareeb

Publikováno v: Journal of affective disorders. 282

Background Monoamine oxidase inhibitors (MAOIs) were the first class of modern antidepressants; however, they are under-utilized as compared to the newer antidepressants. Methods In this systematic review, network meta-analysis was used to investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb1d66d7cc2354defd11ec47cbfeede
https://pubmed.ncbi.nlm.nih.gov/33601690

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Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks

Autor: Athina R Aruldass, Marta M Correia, Neil A. Harrison, Edward T. Bullmore, Phil J. Cowen, Mara Cercignani, Gareth J. Barker, Linda Pointon, Nicholas G. Dowell, Samuel A. Hurley, Jonathan Cavanagh, Tobias C. Wood, Manfred G. Kitzbichler, John McLean, Carmine M. Pariante, Charlotte Clarke

Peripheral inflammation can cause depressive symptoms – but how? Here, we measured brain MRI functional connectivity and micro-structural parameters, including proton density (PD, a measure of tissue water), at 360 cortical and 16 subcortical brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae2a5ce3a17bd516b5bbf52e675d9002
https://doi.org/10.1101/2020.09.09.20191262

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Stress, inflammation and hippocampal subfields in depression: A 7 tesla MRI study

Autor: Phil J. Cowen, Jair C. Soares, Beata R. Godlewska, Sudhakar Selvaraj, Jonika Tannous, Vaishali Tirumalaraju

Publikováno v: Translational Psychiatry
Translational Psychiatry, Vol 10, Iss 1, Pp 1-7 (2020)

Experiencing stressful events throughout one’s life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation such as Interleukin (IL-6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c691ea7c47a4b8fe8745857d50eff4c3
https://ora.ox.ac.uk/objects/uuid:ea54dbbf-fd53-4d50-9072-056fbfbdc431

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