Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Phil G. Morgan"'
Autor:
Phil G. Morgan, Jan-Marino Ramirez, Margaret M. Sedensky, Pavel I. Zimin, Ernst-Bernhard Kayser, Christian B. Woods
Publikováno v:
British Journal of Anaesthesia. 120:1019-1032
Background The mechanisms of action of volatile anaesthetics are unclear. Volatile anaesthetics selectively inhibit complex I in the mitochondrial respiratory chain. Mice in which the mitochondrial complex I subunit NDUFS4 is knocked out [Ndufs4(KO)]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd05a9ebcd6674aa9aa656f2f4fef98c
https://doi.org/10.1016/j.bja.2018.01.036
https://doi.org/10.1016/j.bja.2018.01.036
Autor:
Marni J Falk, Julie R Rosenjack, Erzsebet Polyak, Wichit Suthammarak, Zhongxue Chen, Phil G Morgan, Margaret M Sedensky
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6607 (2009)
Complex I dysfunction is a common, heterogeneous cause of human mitochondrial disease having poorly understood pathogenesis. The extensive conservation of complex I composition between humans and Caenorhabditis elegans permits analysis of individual
Externí odkaz:
https://doaj.org/article/ce4e7d1444054ec687394637313a46a5
Publikováno v:
Genetics, vol 207, iss 3
Mitochondria are best known for harboring pathways involved in ATP synthesis through the tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding these roles were made with Caenorhabditiselegans mutants affecting key co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06683bf293197daccfdafa1877902a91
https://europepmc.org/articles/PMC5887156/
https://europepmc.org/articles/PMC5887156/
Autor:
Masaki Kajimoto, Phil G. Morgan, Nancy G. Isern, Margaret M. Sedensky, Christine Des Rosiers, Dolena R. Ledee, Douglas B. Atkinson, Michael A. Portman, Ernst Bernhard Kayser
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 34:514-521
Anesthetics used in infants and children are implicated in the development of neurocognitive disorders. Although propofol induces neuroapoptosis in developing brain, the underlying mechanisms require elucidation and may have an energetic basis. We st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622297019870169d0392846c7053a3b7
https://doi.org/10.1038/jcbfm.2013.229
https://doi.org/10.1038/jcbfm.2013.229
Autor:
Julie Niezgoda, Phil G. Morgan
Publikováno v:
Pediatric Anesthesia. 23:785-793
Mitochondrial disease, once thought to be a rare clinical entity, is now recognized as an important cause of a wide range of neurological, cardiac, muscle and endocrine disorders [1–3]. The incidence of disorders of the respiratory chain alone is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ff81650ac52155ba1d4ba6d5d6df65
https://doi.org/10.1111/pan.12158
https://doi.org/10.1111/pan.12158
Publikováno v:
Anesthesia & Analgesia. 112:1321-1329
The nematode Caenorhabditis (C.) elegans has been established as a tractable genetic model for studying anesthetic action. 1,2 While reversible immobility produced by volatile anesthetics (VAs) occurs at concentrations higher than minimum alveolar co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76f2b18d713bba0029ed9b0f15e2011
https://doi.org/10.1213/ane.0b013e3182121d37
https://doi.org/10.1213/ane.0b013e3182121d37
Publikováno v:
Journal of Biological Chemistry. 285:40724-40731
Mitochondrial supercomplexes containing complexes I, III, and IV of the electron transport chain are now regarded as an established entity. Supercomplex I·III·IV has been theorized to improve respiratory chain function by allowing quinone channelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bca0f6ca9eb816a6f7e556f3ff92f5
https://doi.org/10.1074/jbc.m110.159608
https://doi.org/10.1074/jbc.m110.159608
Publikováno v:
Journal of Biological Chemistry. 284:6425-6435
Cytochrome c oxidase (COX) is hypothesized to be an important regulator of oxidative phosphorylation. However, no animal phenotypes have been described due to genetic defects in nuclear-encoded subunits of COX. We knocked down predicted homologues of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f89a4d40dcba8e2c0eaf3ad41fc9358
https://doi.org/10.1074/jbc.m805733200
https://doi.org/10.1074/jbc.m805733200
Publikováno v:
Current Pharmacogenomics. 5:125-141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1924367bcf9a13cd35b62f991fe94cb2
https://doi.org/10.2174/157016007780831763
https://doi.org/10.2174/157016007780831763