Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Phil East"'
Autor:
Amanda Dixon-McIver, Phil East, Charles A Mein, Jean-Baptiste Cazier, Gael Molloy, Tracy Chaplin, T Andrew Lister, Bryan D Young, Silvana Debernardi
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2141 (2008)
Acute myeloid leukaemia (AML) is the most common acute leukaemia in adults; however, the genetic aetiology of the disease is not yet fully understood. A quantitative expression profile analysis of 157 mature miRNAs was performed on 100 AML patients r
Externí odkaz:
https://doaj.org/article/18c2a0160e454ae58547d7a035fe6355
Autor:
Jesse Boumelha, Andrea de Castro, Nourdine Bah, Hongui Cha, Sophie de Carné Trécesson, Sareena Rana, Panayiotis Anastasiou, Edurne Mugarza, Christopher Moore, Robert Goldstone, Phil East, Kevin Litchfield, Se-Hoon Lee, Miriam Molina-Arcas, Julian Downward
Oncogenic KRAS impairs anti-tumour immune responses, but effective strategies to combine KRAS inhibitors and immunotherapies have so far proven elusive. In vivo CRISPR-Cas9 screening in an immunogenic murine lung cancer model identifies mechanisms by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c672d746fcfa1e56f0135765efec632
https://doi.org/10.1101/2023.04.13.536740
https://doi.org/10.1101/2023.04.13.536740
Autor:
Patrick J. Pollard, Ian Tomlinson, Mona El-Bahrawy, Lauri Aaltonen, Virpi Launonen, Michael I. Kotlikoff, Maria Flavia Di Renzo, Chiara Bardella, Barbara Costa, Christopher W. Pugh, Richard Poulsom, Gordon Stamp, Patrick H. Maxwell, Emanuela Volpi, Mohammed Yusuf, Bradley Spencer-Dene, John Griffiths, Helen Troy, Deepa Shukla, Kimberley Howarth, Melroy Miranda, Emine Hatipoglu, Emma Nye, Heli Lehtonen, Sakari Vanharanta, Phil East, Yuen-Li Chung, Violetta Steeples, Julie Adam, Linda O'Flaherty, Houman Ashrafian
Supplementary Figure 2 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63279c06787dcbb711a6788a4f91c1ac
https://doi.org/10.1158/0008-5472.22385853
https://doi.org/10.1158/0008-5472.22385853
Autor:
Patrick J. Pollard, Ian Tomlinson, Mona El-Bahrawy, Lauri Aaltonen, Virpi Launonen, Michael I. Kotlikoff, Maria Flavia Di Renzo, Chiara Bardella, Barbara Costa, Christopher W. Pugh, Richard Poulsom, Gordon Stamp, Patrick H. Maxwell, Emanuela Volpi, Mohammed Yusuf, Bradley Spencer-Dene, John Griffiths, Helen Troy, Deepa Shukla, Kimberley Howarth, Melroy Miranda, Emine Hatipoglu, Emma Nye, Heli Lehtonen, Sakari Vanharanta, Phil East, Yuen-Li Chung, Violetta Steeples, Julie Adam, Linda O'Flaherty, Houman Ashrafian
Supplementary Figure 1 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66bd17812622d75cdee182e67af7c11
https://doi.org/10.1158/0008-5472.22385856.v1
https://doi.org/10.1158/0008-5472.22385856.v1
Autor:
Patrick J. Pollard, Ian Tomlinson, Mona El-Bahrawy, Lauri Aaltonen, Virpi Launonen, Michael I. Kotlikoff, Maria Flavia Di Renzo, Chiara Bardella, Barbara Costa, Christopher W. Pugh, Richard Poulsom, Gordon Stamp, Patrick H. Maxwell, Emanuela Volpi, Mohammed Yusuf, Bradley Spencer-Dene, John Griffiths, Helen Troy, Deepa Shukla, Kimberley Howarth, Melroy Miranda, Emine Hatipoglu, Emma Nye, Heli Lehtonen, Sakari Vanharanta, Phil East, Yuen-Li Chung, Violetta Steeples, Julie Adam, Linda O'Flaherty, Houman Ashrafian
Supplementary Table 1 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250f89d56f3c21259d6311a83c7ffbc3
https://doi.org/10.1158/0008-5472.22385847
https://doi.org/10.1158/0008-5472.22385847
Autor:
Edurne Mugarza, Febe Van Maldegem, Jesse Boumelha, Chris Moore, Sareena Rana, Miriam Llorian Sopena, Phil East, Miriam Molina Arcas, Julian Downward
Publikováno v:
Molecular Cancer Therapeutics. 20:P111-P111
Therapeutic KRASG12C inhibitors may substantially improve KRAS-mutant cancer patient care, considering the encouraging clinical data emerging from ongoing clinical trials. Since oncogene-targeting therapies often lead to resistance, the development o
Autor:
Richard Treisman, Stuart Horswell, Aengus Stewart, Gavin Kelly, Phil East, Francesco Gualdrini, Nik Matthews, Cyril Esnault
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2017, 65 (6), pp.1081-1095.e5. ⟨10.1016/j.molcel.2017.02.005⟩
Molecular Cell, Elsevier, 2017, 65 (6), pp.1081-1095.e5. ⟨10.1016/j.molcel.2017.02.005⟩
Summary We investigated the relationship among ERK signaling, histone modifications, and transcription factor activity, focusing on the ERK-regulated ternary complex factor family of SRF partner proteins. In MEFs, activation of ERK by TPA stimulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5fe23111a617313cae3aea01ae42c5
https://hal.archives-ouvertes.fr/hal-03022260
https://hal.archives-ouvertes.fr/hal-03022260
Autor:
Richard Treisman, Francesco Gualdrini, Cyril Esnault, Stuart Horswell, Phil East, Aengus Stewart, Nik Matthews
Publikováno v:
Genes & development
Genes & development, 2014, 28 (9), pp.943-58. ⟨10.1101/gad.239327.114⟩
Genes & Development
Genes & development, 2014, 28 (9), pp.943-58. ⟨10.1101/gad.239327.114⟩
Genes & Development
International audience; The transcription factor SRF (serum response factor) recruits two families of coactivators, the MRTFs (myocardin-related transcription factors) and the TCFs (ternary complex factors), to couple gene transcription to growth fac
Publikováno v:
Genetics. 187:1067-1075
The Elongator complex has been implicated in several cellular processes, including gene expression and tRNA modification. We investigated the biological importance of the Elp3 gene in Drosophila melanogaster. Deletion of Elp3 results in larval lethal
Autor:
Michael I. Kotlikoff, Gordon Stamp, Emma Nye, Linda O'Flaherty, Kimberley Howarth, Barbara Costa, Mona El-Bahrawy, Richard Poulsom, Mohammed Yusuf, Helen Troy, Melroy X. Miranda, Bradley Spencer-Dene, John R. Griffiths, Virpi Launonen, Emine Hatipoglu, Violetta Steeples, Phil East, Deepa Shukla, Patrick H. Maxwell, Christopher W. Pugh, Lauri A. Aaltonen, Houman Ashrafian, Chiara Bardella, Sakari Vanharanta, Maria Flavia Di Renzo, Yuen-Li Chung, Emanuela V. Volpi, Heli J. Lehtonen, Patrick J. Pollard, Ian Tomlinson, Julie Adam
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is caused by mutations in the Krebs cycle enzyme fumarate hydratase (FH). It has been proposed that “pseudohypoxic” stabilization of hypoxia-inducible factor-α (HIF-α) by fumarate accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbcbcf0d49726263f9c3c92b5ed56c4
http://hdl.handle.net/2318/100170
http://hdl.handle.net/2318/100170