Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Phil Cunningham"'
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Accurate quantification of mouse mitochondrial DNA without co-amplification of nuclear mitochondrial insertion sequences
Autor: Afshan N. Malik, Anna Czajka, Phil Cunningham
Publikováno v: Malik, A N, Czajka, A & Cunningham, P 2016, ' Accurate quantification of mouse mitochondrial DNA without co-amplification of nuclear mitochondrial insertion sequences ', MITOCHONDRION . https://doi.org/10.1016/j.mito.2016.05.003
Background:Mitochondria contain extra-nuclear genome in the form of mitochondrial DNA (MtDNA), damage to which can lead to inflammation and bioenergetic deficit. Changes in MtDNA levels are increasingly used as a biomarker of mitochondrial dysfunctio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7949cb183fb119a92ad185172fd7728a
https://pubmed.ncbi.nlm.nih.gov/27181048
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3
Mitochondrial DNA as a non-invasive biomarker: Accurate quantification using real time quantitative PCR without co-amplification of pseudogenes and dilution bias
Autor: Ana Rodriguez-de-Ledesma, Phil Cunningham, Abas H. Laftah, Afshan N. Malik, Rojeen Shahni
Publikováno v: Biochemical and Biophysical Research Communications. 412:1-7
Circulating mitochondrial DNA (MtDNA) is a potential non-invasive biomarker of cellular mitochondrial dysfunction, the latter known to be central to a wide range of human diseases. Changes in MtDNA are usually determined by quantification of MtDNA re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2d3db9b6c471990cb2640abbfa9860
https://doi.org/10.1016/j.bbrc.2011.06.067
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4
[Letter to the editor] Unexpected presence of mycoplasma probes on human microarrays
Autor: William B. Langdon, Matthew Arno, Estibaliz Aldecoa-Otalora, Phil Cunningham
Publikováno v: BioTechniques. 47:1013-1016
Mycoplasma and Microarray Mycoplasma contamination of cultured cells alters gene expression by adversely affecting cellular physiology. Because the presence of mycoplasma in cultures can be difficu...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e22a00268face2823d4fd0e5eca37738
https://doi.org/10.2144/000113271
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6
Regulation of fatty acid binding proteins by hypoxia inducible factors 1α and 2α in the placenta: relevance to pre-eclampsia
Autor: Phil Cunningham, Ayesha Jadoon, Lindsay C. McDermott
Publikováno v: Prostaglandins, leukotrienes, and essential fatty acids. 93
Pre-eclampsia is characterized by placental hypoxia and dyslipidemia. Arachidonic and docosahexanoic acids are essential maternal nutrients for fetal development. They are transported via placental trophoblast cells by membrane and cytosolic fatty ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ea5af3e57e28defebeae8e5514e18c
https://pubmed.ncbi.nlm.nih.gov/25305177
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7
Strong and weak zinc binding sites in human zinc-α2-glycoprotein
Autor: Debolina Hati, Aditya Arun Kumar, Layeque Miah, Alex F. Drake, Tam T. T. Bui, Phil Cunningham, Lindsay C. McDermott, Carmen Domene, Thana'a Mohajer Thaker
Publikováno v: FEBS letters. 587(24)
Zinc-α2-glycoprotein (ZAG) is an adipokine with an MHC class I-like protein fold. Even though zinc causes ZAG to precipitate from plasma during protein purification, no zinc binding has been identified to date. Using mass spectrometry, we demonstrat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c5a5dcab2253845bd7f7c8a317367a
http://ora.ox.ac.uk/objects/uuid:93573994-cfd7-4f82-bb32-a8bb548b0870
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8
Evidence for a divergence in function between two glucocorticoid receptors from a basal teleost
Autor: Nicholas R Bury, Phil Cunningham, Armin Sturm, Yi Li
Publikováno v: BMC Evolutionary Biology, Vol 12, Iss 1, p 137 (2012)
BMC Evolutionary Biology
Background Duplicated glucocorticoid receptors (GR) are present in most teleost fish. The evolutionary advantage of retaining two GRs is unclear, as no subtype specific functional traits or physiological roles have been defined. To identify factors d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e33725de6a9af67e9b166c65f74f3c9
http://www.biomedcentral.com/1471-2148/12/137
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9
Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion
Autor: Dongling Zheng, Peter Kille, Graham P Feeney, Phil Cunningham, Richard D Handy, Christer Hogstrand
Publikováno v: BMC Genomics, Vol 11, Iss 1, p 548 (2010)
BMC Genomics
Background Zinc deficiency is detrimental to organisms, highlighting its role as an essential micronutrient contributing to numerous biological processes. To investigate the underlying molecular events invoked by zinc depletion we performed a tempora
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c8c835d34db5e409b3b2b6704cd357
http://www.biomedcentral.com/1471-2164/11/548
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10
The ABC transporter gene family of Daphnia pulex
Autor: Armin Sturm, Phil Cunningham, Michael Dean
Publikováno v: BMC Genomics
BMC Genomics, Vol 10, Iss 1, p 170 (2009)
Background The large gene superfamily of ABC (ATP-binding cassette) transporters encodes membrane proteins involved in trafficking processes across biological membranes and further essential cell biological functions. ABC transporters are evolutionar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f3320711830b7d1d6a06f31819956d
https://doi.org/10.1186/1471-2164-10-170
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