Výsledky vyhledávání - "Phil C. Gordge"

Correlation of protein kinase A and protein kinase C activities in normal breast tissue

Autor: R.A. Clegg, M.J. Hulme, Phil C Gordge, William R. Miller

Publikováno v: The Breast. 7:49-54

Because of their central role in the transduction of extracelluar signals, protein kinases A (PKA) and C (PKC) are critical enzymes in the control of cellular proliferation and differentiation. We have measured the catalytic activity of PKA (both as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::891f2c229cea5ace7191742eb9e2bfe5
https://doi.org/10.1016/s0960-9776(98)90052-2

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Molecular modelling of tumour-promoting and non-promoting diterpene esters and molecular co-ordinates of the potent irritant resiniferatoxin

Autor: A.Tudor Evans, Fred J. Evans, N. M. Hassan, W.Jonathon Ryves, Alastair Aitken, Pawan Sharma, Phil C. Gordge

Publikováno v: Cancer Letters. 73:77-84

The lowest energy conformer of seventeen diterpenes, representing five different phorbol and daphnane diterpene nuclei, has been generated. TPA possessed the highest minimum free energy of these compounds; all other compounds possessed a lower minimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87666e64cee0e69976ee1d76e20b6b58
https://doi.org/10.1016/0304-3835(93)90248-8

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Semi-synthesis of C203H-resiniferatoxin

Autor: Phil C. Gordge, Patricia Darcy, W. Jonathan Ryves, N. M. Hassan, Fred J. Evans, A. Tudor Evans

Publikováno v: Phytotherapy Research. 8:362-364

There has recently been considerable interest concerning the biochemical and pharmacological mechanisms of action of resiniferatoxin (Rx). Rx is a daphnane diterpene ester, which is part of the phorbol ester family of diterpenes. We have synthesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a3d738ef2f6babf1fdd94ce9abc37d6
https://doi.org/10.1002/ptr.2650080610

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Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue

Autor: Phil C Gordge, R.A. Clegg, William R. Miller, M.J. Hulme

Publikováno v: European journal of cancer (Oxford, England : 1990). (12)

Because of their central role in the transduction of extracellular signals, protein kinases A (PKA) and C (PKC) are critical enzymes in the control of cellular proliferation and differentia t ion. We have measured the catalytic activity of PKA and PK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd165a2516e9ee37b6555cbe9a38ca5c
https://pubmed.ncbi.nlm.nih.gov/9014755

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Protein kinase C does not acutely modulate protein kinase A activity in mammary gland acini prepared from mid-pregnant and mid-lactating rats

Autor: Susan E Withers, Kevin Connor, Phil C Gordge, Roger A. Clegg, William R. Miller

Publikováno v: Biochemical Society transactions. 24(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2733c2dc273922cc3689fd4666aa0a39
https://pubmed.ncbi.nlm.nih.gov/8878882

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Ca(2+)-dependent and Ca(2+)-independent protein kinase C activity in human breast biopsies

Autor: William R. Miller, Phil C Gordge, Roger A. Clegg

Publikováno v: Biochemical Society transactions. 23(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c9683ce88c01ac6902c58d19e1d85c
https://pubmed.ncbi.nlm.nih.gov/8566339

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