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Autor:
Nyamkhishig Sambuughin, Phil B. Cuenca, Henry Rosenberg, Barbara W. Brandom, Timothy J. Tautz, Edward J. Davis, Yoshitatsu Sei, Sheila M. Muldoon, Daniel Sachs, Thomas E. Nelson
Publikováno v:
Anesthesiology. 101:824-830
Background Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle, manifested as a life-threatening hypermetabolic crisis after exposure to anesthetics. Type I ryanodine receptor 1 is the primary gene responsible for susceptibil