Protocol for a single-arm, pilot trial of creatine monohydrate supplementation in patients with Alzheimer’s disease

Autor: Matthew K. Taylor, Jeffrey M. Burns, In-Young Choi, Trent J. Herda, Phil Lee, Aaron N. Smith, Debra K. Sullivan, Russell H. Swerdlow, Heather M. Wilkins

Publikováno v: Pilot and Feasibility Studies, Vol 10, Iss 1, Pp 1-10 (2024)

Abstract Background Impaired brain bioenergetics is a pathological hallmark of Alzheimer’s disease (AD) and is a compelling target for AD treatment. Patients with AD exhibit dysfunction in the brain creatine (Cr) system, which is integral in mainta

Externí odkaz: https://doaj.org/article/69cb69366c884bc0acef5ad16e3c9069

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Autor: Yu-Han H. Hsu, Greta Pintacuda, Ruize Liu, Eugeniu Nacu, April Kim, Kalliopi Tsafou, Natalie Petrossian, William Crotty, Jung Min Suh, Jackson Riseman, Jacqueline M. Martin, Julia C. Biagini, Daya Mena, Joshua K.T. Ching, Edyta Malolepsza, Taibo Li, Tarjinder Singh, Tian Ge, Shawn B. Egri, Benjamin Tanenbaum, Caroline R. Stanclift, Annie M. Apffel, Steven A. Carr, Monica Schenone, Jake Jaffe, Nadine Fornelos, Hailiang Huang, Kevin C. Eggan, Kasper Lage, Stephan Ripke, Benjamin M. Neale, Aiden Corvin, James T.R. Walters, Kai-How Farh, Peter A. Holmans, Phil Lee, Brendan Bulik-Sullivan, David A. Collier, Tune H. Pers, Ingrid Agartz, Esben Agerbo, Margot Albus, Madeline Alexander, Farooq Amin, Silviu A. Bacanu, Martin Begemann, Richard A. Belliveau, Jr., Judit Bene, Sarah E. Bergen, Elizabeth Bevilacqua, Tim B. Bigdeli, Donald W. Black, Richard Bruggeman, Nancy G. Buccola, Randy L. Buckner, William Byerley, Wiepke Cahn, Guiqing Cai, Dominique Campion, Rita M. Cantor, Vaughan J. Carr, Noa Carrera, Stanley V. Catts, Kimberley D. Chambert, Raymond C.K. Chan, Ronald Y.L. Chan, Eric Y.H. Chen, Wei Cheng, Eric FC. Cheung, Siow Ann Chong, C. Robert Cloninger, David Cohen, Nadine Cohen, Paul Cormican, Nick Craddock, James J. Crowley, David Curtis, Michael Davidson, Kenneth L. Davis, Franziska Degenhardt, Jurgen Del Favero, Ditte Demontis, Dimitris Dikeos, Timothy Dinan, Srdjan Djurovic, Gary Donohoe, Elodie Drapeau, Jubao Duan, Frank Dudbridge, Naser Durmishi, Peter Eichhammer, Johan Eriksson, Valentina Escott-Price, Laurent Essioux, Ayman H. Fanous, Martilias S. Farrell, Josef Frank, Lude Franke, Robert Freedman, Nelson B. Freimer, Marion Friedl, Joseph I. Friedman, Menachem Fromer, Giulio Genovese, Lyudmila Georgieva, Ina Giegling, Paola Giusti-Rodríguez, Stephanie Godard, Jacqueline I. Goldstein, Vera Golimbet, Srihari Gopal, Jacob Gratten, Lieuwe de Haan, Christian Hammer, Marian L. Hamshere, Mark Hansen, Thomas Hansen, Vahram Haroutunian, Annette M. Hartmann, Frans A. Henskens, Stefan Herms, Joel N. Hirschhorn, Per Hoffmann, Andrea Hofman, Mads V. Hollegaard, David M. Hougaard, Masashi Ikeda, Inge Joa, Antonio Julià, René S. Kahn, Luba Kalaydjieva, Sena Karachanak-Yankova, Juha Karjalainen, David Kavanagh, Matthew C. Keller, James L. Kennedy, Andrey Khrunin, Yunjung Kim, Janis Klovins, James A. Knowles, Bettina Konte, Vaidutis Kucinskas, Zita Ausrele Kucinskiene, Hana Kuzelova-Ptackova, Anna K. Kähler, Claudine Laurent, Jimmy Lee, S. Hong Lee, Sophie E. Legge, Bernard Lerer, Miaoxin Li, Tao Li, Kung-Yee Liang, Jeffrey Lieberman, Svetlana Limborska, Carmel M. Loughland, Jan Lubinski, Jouko Lönnqvist, Milan Macek, Patrik K.E. Magnusson, Brion S. Maher, Wolfgang Maier, Jacques Mallet, Sara Marsal, Manuel Mattheisen, Morten Mattingsdal, Robert W. McCarley, Colm McDonald, Andrew M. McIntosh, Sandra Meier, Carin J. Meijer, Bela Melegh, Ingrid Melle, Raquelle I. Mesholam-Gately, Andres Metspalu, Patricia T. Michie, Lili Milani, Vihra Milanova, Younes Mokrab, Derek W. Morris, Ole Mors, Kieran C. Murphy, Robin M. Murray, Inez Myin-Germeys, Bertram Müller-Myhsok, Mari Nelis, Igor Nenadic, Deborah A. Nertney, Gerald Nestadt, Kristin K. Nicodemus, Liene Nikitina-Zake, Laura Nisenbaum, Annelie Nordin, Eadbhard O'Callaghan, Colm O'Dushlaine, F. Anthony O'Neill, Sang-Yun Oh, Ann Olincy, Line Olsen, Jim Van Os, Christos Pantelis, George N. Papadimitriou, Sergi Papiol, Elena Parkhomenko, Michele T. Pato, Tiina Paunio, Milica Pejovic-Milovancevic, Diana O. Perkins, Olli Pietiläinen, Jonathan Pimm, Andrew J. Pocklington, John Powell, Alkes Price, Ann E. Pulver, Shaun M. Purcell, Digby Quested, Henrik B. Rasmussen, Abraham Reichenberg, Mark A. Reimers, Alexander L. Richards, Joshua L. Roffman, Panos Roussos, Douglas M. Ruderfer, Veikko Salomaa, Alan R. Sanders, Ulrich Schall, Christian R. Schubert, Thomas G. Schulze, Sibylle G. Schwab, Edward M. Scolnick, Rodney J. Scott, Larry J. Seidman, Jianxin Shi, Engilbert Sigurdsson, Teimuraz Silagadze, Jeremy M. Silverman, Kang Sim, Petr Slominsky, Jordan W. Smoller, Hon-Cheong So, Chris C.A. Spencer, Eli A. Stahl, Hreinn Stefansson, Stacy Steinberg, Elisabeth Stogmann, Richard E. Straub, Eric Strengman, Jana Strohmaier, T Scott Stroup, Mythily Subramaniam, Jaana Suvisaari, Dragan M. Svrakic, Jin P. Szatkiewicz, Erik Söderman, Srinivas Thirumalai, Draga Toncheva, Sarah Tosato, Juha Veijola, John Waddington, Dermot Walsh, Dai Wang, Qiang Wang, Bradley T. Webb, Mark Weiser, Dieter B. Wildenauer, Nigel M. Williams, Stephanie Williams, Stephanie H. Witt, Aaron R. Wolen, Emily H.M. Wong, Brandon K. Wormley, Hualin Simon Xi, Clement C. Zai, Xuebin Zheng, Fritz Zimprich, Naomi R. Wray, Kari Stefansson, Peter M. Visscher, Rolf Adolfsson, Ole A. Andreassen, Douglas H.R. Blackwood, Elvira Bramon, Joseph D. Buxbaum, Anders D. Børglum, Sven Cichon, Ariel Darvasi, Enrico Domenici, Hannelore Ehrenreich, Tõnu Esko, Pablo V. Gejman, Michael Gill, Hugh Gurling, Christina M. Hultman, Nakao Iwata, Assen V. Jablensky, Erik G. Jönsson, Kenneth S. Kendler, George Kirov, Jo Knight, Todd Lencz, Douglas F. Levinson, Qingqin S. Li, Jianjun Liu, Anil K. Malhotra, Steven A. McCarroll, Andrew McQuillin, Jennifer L. Moran, Preben B. Mortensen, Bryan J. Mowry, Markus M. Nöthen, Roel A. Ophoff, Michael J. Owen, Aarno Palotie, Carlos N. Pato, Tracey L. Petryshen, Danielle Posthuma, Marcella Rietschel, Brien P. Riley, Dan Rujescu, Pak C. Sham, Pamela Sklar, David St Clair, Daniel R. Weinberger, Jens R. Wendland, Thomas Werge, Mark J. Daly, Patrick F. Sullivan, Michael C. O'Donovan, Shengying Qin, Akira Sawa, Rene Kahn, Kyung Sue Hong, Wenzhao Shi, Ming Tsuang, Masanari Itokawa, Gang Feng, Stephen J. Glatt, Xiancang Ma, Jinsong Tang, Yunfeng Ruan, Feng Zhu, Yasue Horiuchi, Byung Dae Lee, Eun-Jeong Joo, Woojae Myung, Kyooseob Ha, Hong-Hee Won, Ji Hyung Baek, Young Chul Chung, Sung-Wan Kim, Agung Kusumawardhani, Wei J. Chen, Hai-Gwo Hwu, Akitoyo Hishimoto, Ikuo Otsuka, Ichiro Sora, Tomoko Toyota, Takeo Yoshikawa, Hiroshi Kunugi, Kotaro Hattori, Sayuri Ishiwata, Shusuke Numata, Tetsuro Ohmori, Makoto Arai, Yuji Ozeki, Kumiko Fujii, Se Joo Kim, Heon-Jeong Lee, Yong Min Ahn, Se Hyun Kim, Kazufumi Akiyama, Kazutaka Shimoda, Makoto Kinoshita

Publikováno v: iScience, Vol 26, Iss 5, Pp 106701- (2023)

Summary: Genetics have nominated many schizophrenia risk genes and identified convergent signals between schizophrenia and neurodevelopmental disorders. However, functional interpretation of the nominated genes in the relevant brain cell types is oft

Externí odkaz: https://doaj.org/article/49cc77d8d4ee4572b1f6ef76532d303e

A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise

Autor: Dreu White, Casey S. John, Ashley Kucera, Bryce Truver, Rebecca J. Lepping, Paul J. Kueck, Phil Lee, Laura Martin, Sandra A. Billinger, Jeffrey M. Burns, Jill K. Morris, Eric D. Vidoni

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Exercise likely has numerous benefits for brain and cognition. However, those benefits and their causes remain imprecisely defined. If the brain does benefit from exercise it does so primarily through cumulative brief, “acute” exposures

Externí odkaz: https://doaj.org/article/088de346d53049a4b24ab5be9b41efc6

Reduced Hippocampal Volume and Neurochemical Response to Adult Stress Exposure in a Female Mouse Model of Urogenital Hypersensitivity

Autor: Aaron D. Brake, Xiaofang Yang, Chu-Yu Lee, Phil Lee, Paul Keselman, Olivia C. Eller, In-Young Choi, Janna L. Harris, Julie A. Christianson

Publikováno v: Frontiers in Pain Research, Vol 3 (2022)

Early life stress exposure significantly increases the risk of developing chronic pain syndromes and comorbid mood and metabolic disorders later in life. Structural and functional changes within the hippocampus have been shown to contribute to many e

Externí odkaz: https://doaj.org/article/fa4a2466ba89436b91747de32f49e288

Frequency drift in MR spectroscopy at 3T

Autor: Steve C.N. Hui, Mark Mikkelsen, Helge J. Zöllner, Vishwadeep Ahluwalia, Sarael Alcauter, Laima Baltusis, Deborah A. Barany, Laura R. Barlow, Robert Becker, Jeffrey I. Berman, Adam Berrington, Pallab K. Bhattacharyya, Jakob Udby Blicher, Wolfgang Bogner, Mark S. Brown, Vince D. Calhoun, Ryan Castillo, Kim M. Cecil, Yeo Bi Choi, Winnie C.W. Chu, William T. Clarke, Alexander R. Craven, Koen Cuypers, Michael Dacko, Camilo de la Fuente-Sandoval, Patricia Desmond, Aleksandra Domagalik, Julien Dumont, Niall W. Duncan, Ulrike Dydak, Katherine Dyke, David A. Edmondson, Gabriele Ende, Lars Ersland, C. John Evans, Alan S.R. Fermin, Antonio Ferretti, Ariane Fillmer, Tao Gong, Ian Greenhouse, James T. Grist, Meng Gu, Ashley D. Harris, Katarzyna Hat, Stefanie Heba, Eva Heckova, John P. Hegarty, II, Kirstin-Friederike Heise, Shiori Honda, Aaron Jacobson, Jacobus F.A. Jansen, Christopher W. Jenkins, Stephen J. Johnston, Christoph Juchem, Alayar Kangarlu, Adam B. Kerr, Karl Landheer, Thomas Lange, Phil Lee, Swati Rane Levendovszky, Catherine Limperopoulos, Feng Liu, William Lloyd, David J. Lythgoe, Maro G. Machizawa, Erin L. MacMillan, Richard J. Maddock, Andrei V. Manzhurtsev, María L. Martinez-Gudino, Jack J. Miller, Heline Mirzakhanian, Marta Moreno-Ortega, Paul G. Mullins, Shinichiro Nakajima, Jamie Near, Ralph Noeske, Wibeke Nordhøy, Georg Oeltzschner, Raul Osorio-Duran, Maria C.G. Otaduy, Erick H. Pasaye, Ronald Peeters, Scott J. Peltier, Ulrich Pilatus, Nenad Polomac, Eric C. Porges, Subechhya Pradhan, James Joseph Prisciandaro, Nicolaas A Puts, Caroline D. Rae, Francisco Reyes-Madrigal, Timothy P.L. Roberts, Caroline E. Robertson, Jens T. Rosenberg, Diana-Georgiana Rotaru, Ruth L O'Gorman Tuura, Muhammad G. Saleh, Kristian Sandberg, Ryan Sangill, Keith Schembri, Anouk Schrantee, Natalia A. Semenova, Debra Singel, Rouslan Sitnikov, Jolinda Smith, Yulu Song, Craig Stark, Diederick Stoffers, Stephan P. Swinnen, Rongwen Tain, Costin Tanase, Sofie Tapper, Martin Tegenthoff, Thomas Thiel, Marc Thioux, Peter Truong, Pim van Dijk, Nolan Vella, Rishma Vidyasagar, Andrej Vovk, Guangbin Wang, Lars T. Westlye, Timothy K. Wilbur, William R. Willoughby, Martin Wilson, Hans-Jörg Wittsack, Adam J. Woods, Yen-Chien Wu, Junqian Xu, Maria Yanez Lopez, David K.W. Yeung, Qun Zhao, Xiaopeng Zhou, Gasper Zupan, Richard A.E. Edden

Publikováno v: NeuroImage, Vol 241, Iss , Pp 118430- (2021)

Purpose: Heating of gradient coils and passive shim components is a common cause of instability in the B0 field, especially when gradient intensive sequences are used. The aim of the study was to set a benchmark for typical drift encountered during M

Externí odkaz: https://doaj.org/article/48f8d08362cc4df585976e00c9c0c63f