Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Phil, Jeffrey"'
Autor:
Jun Ma, Kristen Hurov, Johanna lahdenranta, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Eric Haines, Kevin McDonnell, Philip Brandish, Nicholas Keen, Fanglei You, Mike Kelly, Heather Cohen, Drasti Kanakia, Carly Campbell, David Witty, Stephen Blakemore, Phil Jeffrey
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)
Externí odkaz:
https://doaj.org/article/4724c01b9ec7407d90abf3570e647883
Autor:
Kristen Hurov, Johanna lahdenranta, Punit Upadhyaya, Phil Jeffrey, Hitesh Mistry, Fernando Ortega, Christophe Chassagnole
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/379d284c453b41a4b6783c643e4ce1aa
Autor:
Kristen Hurov, Johanna lahdenranta, Gemma Mudd, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Kevin McDonnell, Philip Brandish, Nicholas Keen, Phil Jeffrey
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/6414f70ad96342768354adee2801717c
Autor:
Matthew J. Foulkes, Katherine M. Henry, Julien Rougeot, Edward Hooper-Greenhill, Catherine A. Loynes, Phil Jeffrey, Angeleen Fleming, Caroline O. Savage, Annemarie H. Meijer, Simon Jones, Stephen A. Renshaw
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract There remains a need to identify novel pro-resolution drugs for treatment of inflammatory disease. To date, there are no neutrophil-specific anti-inflammatory treatments in clinical use, perhaps due to our lack of understanding of how drugs
Externí odkaz:
https://doaj.org/article/29c19465e7d54a27a84bf1da012fdddf
Autor:
Kevin Lee, Nicholas Keen, Phil Jeffrey, Michael J. Skynner, Johanna Lahdenranta, Eric Haines, Carly Campbell, Peter U. Park, Amy N. Brown, Heather S. Scott, Sophie M. Watcham, Katerine Van Rietschoten, Paul J. Beswick, Helen Harrison, Gemma E. Mudd, Liuhong Chen, Gavin Bennett, Michael Rigby
Supplementary Figure from BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0148ec0572dcf04288b6c7ac55148911
https://doi.org/10.1158/1535-7163.22523875
https://doi.org/10.1158/1535-7163.22523875
Autor:
Kristen Hurov, Lia Luus, Johanna Lahdenranta, Punit Upadhyaya, Heather Cohen, Chinmayee Shah, Julia Kristensson, Peter Brown, Gemma Mudd, Carly Campbell, Elizabeth Repash, Eric Haines, Sailaja Battula, Mike Kelly, Phil Jeffrey, Paul Beswick, Liuhong Chen, Kevin McDonnell, Philip Brandish, Nicholas Keen
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f969126e40fad5d1270f04621dffbb4
https://doi.org/10.1136/jitc-2022-sitc2022.1340
https://doi.org/10.1136/jitc-2022-sitc2022.1340
Autor:
Gemma E. Mudd, Heather Scott, Liuhong Chen, Katerine van Rietschoten, Gabriela Ivanova-Berndt, Katarzyna Dzionek, Amy Brown, Sophie Watcham, Lewi White, Peter U. Park, Phil Jeffrey, Mike Rigby, Paul Beswick
Publikováno v:
Journal of medicinal chemistry. 65(21)
Bicycle toxin conjugates (BTCs) are a promising new class of molecules for targeted delivery of toxin payloads into tumors. Herein we describe the discovery of BT8009, a Nectin-4 targeting BTC currently under clinical evaluation. Nectin-4 is overexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef778895f7d675a7a657e81ab8226e23
https://pubmed.ncbi.nlm.nih.gov/36204777
https://pubmed.ncbi.nlm.nih.gov/36204777
Autor:
Punit Upadhyaya, Julia Kristensson, Johanna Lahdenranta, Elizabeth Repash, Jun Ma, Jessica Kublin, Gemma E. Mudd, Lia Luus, Phil Jeffrey, Kristen Hurov, Kevin McDonnell, Nicholas Keen
Publikováno v:
Journal of medicinal chemistry. 65(14)
CD137 (4-1BB) is a co-stimulatory receptor on immune cells and Nectin-4 is a cell adhesion molecule that is overexpressed in multiple tumor types. Using a series of poly(ethylene glycol) (PEG)-based linkers, synthetic bicyclic peptides targeting CD13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c27610ba02170186a7dd0cfd287a4aa
https://pubmed.ncbi.nlm.nih.gov/35819182
https://pubmed.ncbi.nlm.nih.gov/35819182
Autor:
Lia Luus, Kristen Hurov, Johanna Lahdenranta, Chinmayee Shah, Anna Devlen, Julia Kristensson, Peter Brown, Cara Bray, Heather Cohen, Carly Campbell, Gemma Mudd, Punit Upadhyaya, Kevin McDonnell, Hongmei Xu, Phil Jeffrey, Philip E. Brandish, Nicholas Keen
Publikováno v:
Cancer Research. 83:1832-1832
We have developed a new class of modular synthetic drugs, termed Bicycle® tumor-targeted immune cell agonists (Bicycle® TICAs), which are multi-specific molecules composed of constrained bicyclic peptides (Bicycles)1. The first molecule of this cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46754c475147f5c4c10bcd415df05928
https://doi.org/10.1158/1538-7445.am2023-1832
https://doi.org/10.1158/1538-7445.am2023-1832
Autor:
Phil Jeffrey, Scott Summerfield
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 1, Pp 33-37 (2010)
A wide variety of models have been developed over the years to predict blood–brain barrier (BBB) penetration, most of them have focussed on predicting total concentrations of drug and then expressing this as a brain:blood (or plasma) ratio. This ap
Externí odkaz:
https://doaj.org/article/01b1d732c2bd4e22b73975dee2b5bef5