Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Phikelelani Ngubane"'
Publikováno v:
Journal of Obstetrics and Gynaecology, Vol 44, Iss 1 (2024)
Background Prediabetes (PD) is associated with intermediate hyperglycaemia, dyslipidaemia, reduced nitric oxide (NO) bioavailability and moderate hypertension. All these factors are risk factor for preeclampsia (PE). However, the effects of the PD on
Externí odkaz:
https://doaj.org/article/06d1d2d9dfe444ea882ce0995006f6e4
Autor:
Malishca Pillay, Palesa Mosili, Akinjide Akinnuga, Ntethelelo Sibiya, Phikelelani Ngubane, Andile Khathi
Publikováno v:
Diabetology, Vol 4, Iss 3, Pp 406-417 (2023)
There is a correlation between the existence of type 2 diabetes mellitus (T2DM) and the development of thyroid disorders. Prediabetes is a progressive state of moderate insulin resistance that often precedes the onset of T2DM. However, the associatio
Externí odkaz:
https://doaj.org/article/2c829bf0661c46e5a25da9d68d64809b
Autor:
Nokukhanya Thembane, Sphamandla Hlatshwayo, Mlungisi Ngcobo, Phikelelani Ngubane, Nceba Gqaleni
Publikováno v:
Plants, Vol 13, Iss 12, p 1608 (2024)
The treatment and management of diabetes mellitus (DM) with conventional therapies, such as insulin injections and oral hypoglycemic agents, present significant challenges due to their side effects and burdensome administration. Therapies often manag
Externí odkaz:
https://doaj.org/article/aed8024d5ad24d9e82abb55ae98bac33
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
In light of the expected increase in the prevalence of diabetes mellitus due to an aging population, sedentary lifestyles, an increase in obesity, and unhealthy diets, there is a need to identify potential pharmacological agents that can heighten the
Externí odkaz:
https://doaj.org/article/70d9c8835538427f8271bd317c487908
Autor:
Angezwa Siboto, Akinjide Moses Akinnuga, Muhammed Bilaal Ismail, Irvin Noel Booysen, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi
Publikováno v:
Diabetology, Vol 3, Iss 4, Pp 524-538 (2022)
Non-alcoholic fatty liver disease (NAFLD) is associated with prediabetes and can be treated by using a combination of metformin and dietary modification. However, people often fail to adhere to dietary modifications and become more dependent on pharm
Externí odkaz:
https://doaj.org/article/cb0c4c6860fb4502b524131e692ec654
Publikováno v:
BMC Cardiovascular Disorders, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Hyperglycaemia is known to result in oxidative stress tissue injury and dysfunction. Interestingly, studies have reported hepatic and renal oxidative stress injury during prediabetes; however, any injury to the myocardium during p
Externí odkaz:
https://doaj.org/article/75f7146f070040a788caf7d10d30fd2c
Autor:
Auxiliare Kuretu, Charles Arineitwe, Mamosheledi Mothibe, Phikelelani Ngubane, Andile Khathi, Ntethelelo Sibiya
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Mitochondrial impairment has been associated with the development of insulin resistance, the hallmark of type 2 diabetes mellitus (T2DM). However, the relationship between mitochondrial impairment and insulin resistance is not fully elucidated due to
Externí odkaz:
https://doaj.org/article/34c3e1c6449a44eda21f7658dcc22a72
Autor:
Palesa Mosili, Bongeka Cassandra Mkhize, Phikelelani Ngubane, Ntethelelo Sibiya, Andile Khathi
Publikováno v:
Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background Altered function of the hypothalamic–pituitary–adrenal (HPA) axis in type 2 diabetic patients, a condition preceded by pre-diabetes, has been shown to increase the risk of depression as well as cause downstream effects resulti
Externí odkaz:
https://doaj.org/article/b6d9f177f4cc46ba92ddd91d833dfe27
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 139, Iss , Pp 111570- (2021)
Background: The prevalence of prediabetes correlates with increased incidence of chronic kidney disease (CKD). This study was aimed at investigating the effects of oleanolic acid (OA) on markers associated with CKD in the prediabetic rat model. Metho
Externí odkaz:
https://doaj.org/article/dfc3245b187e44b48eee9ad45ca8f4e3
Publikováno v:
Therapeutic Advances in Endocrinology and Metabolism, Vol 11 (2020)
Aims: Sub-clinical inflammation during pre-diabetes is one of the predisposing factors that facilitates the progression of pre-diabetes to type 2 diabetes. The administration of oleanolic acid (OA) with or without dietary intervention ameliorates the
Externí odkaz:
https://doaj.org/article/8382557005b141c3a7a7954ec8a8f9ca