Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Phi Tang"'
Autor:
Sonya G. Lehto, Weiya Wang, Narender R. Gavva, Hong Deng, Mark H. Norman, Lana Klionsky, Nobuko Nishimura, Brad Youngblood, Phi Tang, Vu Van Ma, Jiyun Chen, Vijay Keshav Gore, Michael D. Bartberger, Nuria A. Tamayo, Tiffany L. Correll, Yunxin Bo
Publikováno v:
Journal of Medicinal Chemistry. 55:1593-1611
The transient receptor potential melastatin type 8 (TRPM8) is a nonselective cation channel primarily expressed in a subpopulation of sensory neurons that can be activated by a wide range of stimuli, including menthol, icilin, and cold temperatures (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1beaabfc08eed8ea8dfb711873a8ed34
https://doi.org/10.1021/jm2013634
https://doi.org/10.1021/jm2013634
Autor:
Vu Van Ma, Maosheng Zhang, Nuria A. Tamayo, Vijay Keshav Gore, Weiya Wang, Phi Tang, Holger Monenschein, Daniel B. Horne, Mark H. Norman, Michael D. Bartberger, Yunxin Bo, Jeffrey Clarine, Thomas T. Nguyen, Carl Davis, Beth D. Youngblood, Matthew R. Kaller, Sonya G. Lehto, Narender R. Gavva, Nobuko Nishimura
Publikováno v:
Journal of medicinal chemistry. 57(7)
Transient receptor potential melastatin 8 (TRPM8) is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system. TRPM8 is the predominant mammalian cold temperature thermosensor and is activated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31259e241c7b92b3f659ee0304d6bff2
https://pubmed.ncbi.nlm.nih.gov/24597733
https://pubmed.ncbi.nlm.nih.gov/24597733
Autor:
Liping H. Pettus, Vassil I. Ognyanov, James J. S. Treanor, Phi Tang, Mark H. Norman, Xianghong Wang, Narender R. Gavva, Helming Tan, Rami Tamir, Partha P. Chakrabarti
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(23)
A series of trisubstituted pyrimidines were synthesized to improve aqueous solubility of our first TRPV1 clinical candidate (1; AMG 517), while maintaining potent TRPV1 inhibitory activity. Structure–activity and structure–solubility studies led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38960115873ad338c2f59a2cdf4584f4
https://pubmed.ncbi.nlm.nih.gov/17937985
https://pubmed.ncbi.nlm.nih.gov/17937985
Autor:
Charles Bernard, Vijay Keshav Gore, Rami Tamir, Anthony W. Bannon, Hui-Ling Wang, Phi Tang, Sekhar Surapaneni, Jodie Katon, Oliver R. Thiel, Narender R. Gavva, Chenera Balan, Mark H. Norman, Nobuko Nishimura, Celia Dominguez, Vu Van Ma, Elizabeth M. Doherty, James J. S. Treanor
Publikováno v:
Journal of medicinal chemistry. 50(15)
Based on the previously reported clinical candidate, AMG 517 (compound 1), a series of related piperazinylpyrimidine analogues were synthesized and evaluated as antagonists of the vanilloid 1 receptor (VR1 or TRPV1). Optimization of in vitro potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519c2957e1742243aa04fd73fa4aec44
https://pubmed.ncbi.nlm.nih.gov/17585751
https://pubmed.ncbi.nlm.nih.gov/17585751
Autor:
Hui-Ling Wang, Jodie Katon, Chenera Balan, Anthony W. Bannon, Charles Bernard, Elizabeth M. Doherty, Celia Dominguez, Narender R. Gavva, Vijay Gore, Vu Ma, Nobuko Nishimura, Sekhar Surapaneni, Phi Tang, Rami Tamir, Oliver Thiel, James J. S. Treanor, Mark H. Norman
Publikováno v:
Journal of Medicinal Chemistry; Jul2007, Vol. 50 Issue 15, p3528-3539, 12p
Publikováno v:
Inzynieria Mineralna; 2021, Vol. 48 Issue 2, p129-148, 20p
Autor:
Saxonberg, Steven
Publikováno v:
Journal of Civil Society; Jun2021, Vol. 17 Issue 2, p199-218, 20p
Autor:
Anwar, Mohd, Imran, Ashiq
Publikováno v:
2015 IEEE 2nd International Conference on Cyber Security & Cloud Computing; 2015, p104-110, 7p
Publikováno v:
Ethics & Information Technology; Jun2015, Vol. 17 Issue 2, p113-124, 12p
The rise of internet and social media usage in the past couple of decades has presented a very useful tool for many different industries and fields to utilize. With much of the world's population writing their opinions on various products and service
