INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling

Autor: Phi Luong, Matija Hedl, Jie Yan, Tao Zuo, Tian-Min Fu, Xiaomo Jiang, Jay R Thiagarajah, Steen H Hansen, Cammie F Lesser, Hao Wu, Clara Abraham, Wayne I Lencer

Publikováno v: eLife, Vol 7 (2018)

Homeostasis at mucosal surfaces requires cross-talk between the environment and barrier epithelial cells. Disruption of barrier function typifies mucosal disease. Here we elucidate a bifunctional role in coordinating this cross-talk for the inflammat

Externí odkaz: https://doaj.org/article/88d7b7c576ce48a69294af2d0e3bf0e0

p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth

Autor: Hanyue Ouyang, Steen H. Hansen, Morten Frödin, Phi Luong

Publikováno v: Oncogene
Ouyang, H, Luong, P, Frödin, M & Hansen, S H 2020, ' p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth ', Oncogene, vol. 39, no. 33, pp. 5570-5587 . https://doi.org/10.1038/s41388-020-1385-2

The ARHGAP35 gene encoding p190A RhoGAP (p190A) is significantly altered by both mutation and allelic deletion in human cancer, but the functional implications of such alterations are not known. Here, we demonstrate for the first time that p190A is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455f84c6b6b45fc1f3bf08fd0a7383cd
http://europepmc.org/articles/PMC7426264

Assessment of Patient Satisfaction With Appearance, Psychological Well-being, and Aging Appraisal After Upper Blepharoplasty: A Multicenter Prospective Cohort Study

Autor: Kim Phi Luong, Lieke C.M. Vissers, Stefan Hummelink, Ileen Domela Nieuwenhuis, Harm P. Slijper, Dietmar J.O. Ulrich

Publikováno v: Aesthetic Surgery Journal, 42, 340-348
Aesthetic Surgery Journal, 42, 4, pp. 340-348

Background To determine the success of an upper blepharoplasty, a popular cosmetic procedure, it is essential to measure outcomes from the patient perspective because these often outweigh objective outcomes. Objectives This study aimed to assess pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9324dbf0fef7b13d5759ac1147d647a8
http://hdl.handle.net/2066/248158

Small-molecule modulators of INAVA cytosolic condensate and cell-cell junction assemblies

Autor: Denis Chang, Wayne I. Lencer, Phi Luong, Lee Barrett, Jamie LeBarron, Qian Li, Michael W. Anderson

Publikováno v: The Journal of cell biology. 220(9)

Epithelial cells lining mucosal surfaces distinctively express the inflammatory bowel disease risk gene INAVA. We previously found that INAVA has dual and competing functions: one at lateral membranes where it affects mucosal barrier function and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82745b1b18188cc074bd6b9a58b3b290
https://pubmed.ncbi.nlm.nih.gov/34251416

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

Autor: Adrienne W. Paton, Yevgeniy V. Serebrenik, Mariska S. Simpson, Eva Cloots, Michael J. Grey, Nicole LeDuc, Sophie Janssens, Wayne I. Lencer, Phi Luong, Sven Eyckerman, James C. Paton, Jay R. Thiagarajah, Delphine De Sutter, Markus A. Seeliger, Heidi De Luca

Publikováno v: JOURNAL OF CELL BIOLOGY
The Journal of Cell Biology

Grey et al. discover a mechanism by which the epithelial-specific ER stress sensor IRE1β acts as a negative regulator of IRE1α. IRE1β interacts directly with IRE1α to suppress XBP-1 splicing and modify the unfolded protein response to endoplasmic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0e2cb305831c56f75ea4fed522177b
https://doi.org/10.1083/jcb.201904048