Development of novel serotonin 7‐targeting compounds based on the 2‐dimethylaminotetralin scaffold (1059.13)

Autor: Yue Liu, Raymond G. Booth, Wanying Zhu, Tania C. Córdova-Sintjago, Clinton E. Canal, Daniel Felsing

Publikováno v: The FASEB Journal. 28

The serotonin (5-HT) 7 G protein-coupled receptor (GPCR) is the most recent 5-HT receptor cloned, and is expressed in both the periphery and the CNS. Reports propose 5-HT7 receptors are involved in a wide range of CNS functions, including modulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f9c96d4420c5e8f893805dc7871ac2d
https://doi.org/10.1096/fasebj.28.1_supplement.1059.13

Putative σ3 sites in mammalian brain have histamine H1 receptor properties: evidence from ligand binding and distribution studies with the novel H1 radioligand [ ]-(−)-trans-1-phenyl-3-aminotetralin

Autor: Randall L Brown, Raymond G. Booth, Cindy P. Lawler, Constance E. Owens, Ehren C. Bucholtz, Steven D. Wyrick

Publikováno v: Brain Research. 837:95-105

A novel phenylaminotetralin (PAT) radioligand, [ 3 H ]-(1R,3S)-(−)-trans-1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene ([ 3 H ]-[−]-trans-H2-PAT), is shown here to label a saturable (Bmax=39±6 fmol/mg protein) population of sites with h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07baca8c8feb7c13740454718ddd3bfb
https://doi.org/10.1016/s0006-8993(99)01602-9

A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors

Autor: Neepa Y. Choksi, Remko A. Bakker, Henk Timmerman, Rob Leurs, Raymond G. Booth, William B. Nix, Nader H. Moniri

Publikováno v: Booth, R G, Moniri, N H, Bakker, R A, Choksi, N Y, Nix, W B, Timmerman, H & Leurs, R 2002, ' A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors ', The Journal of Pharmacology and Experimental Therapeutics, vol. 302, no. 1, pp. 328-36 . https://doi.org/10.1124/jpet.302.1.328
The Journal of Pharmacology and Experimental Therapeutics, 302(1), 328-36. American Society for Pharmacology and Experimental Therapeutics

Previously, (−)- trans -1-phenyl-3- N , N -dimethylamino-1,2,3,4-tetrahydronaphthalene ([−]- trans -H 2 -PAT) was shown to activate stereospecifically histamine H 1 receptors coupled to modulation of tyrosine hydroxylase activity in guinea pig an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16a23a4d50ec9c74f2e0e3d7b8a42f1
https://research.vu.nl/en/publications/e04cd273-9daf-4df4-b731-96b72716adb4

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