Výsledky vyhledávání - "Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Binding Sites [Medical Subject Headings]"

The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

Autor: Suyapa Amador-Cubero, Sebastien Viollet, Laura Sánchez, Alejandro Rubio-Roldan, Pablo Tristan-Ramos, Sara R. Heras, Gaël Cristofari, Guillermo Peris

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.5712. ⟨10.1038/s41467-020-19430-4⟩
Repositori Universitat Jaume I
Universitat Jaume I
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.5712. ⟨10.1038/s41467-020-19430-4⟩
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname

Nearly half of the human genome is made of transposable elements (TEs) whose activity continues to impact its structure and function. Among them, Long INterspersed Element class 1 (LINE-1 or L1) elements are the only autonomously active TEs in humans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a799ef5b76da6b6658f2cff13a6154
https://doaj.org/article/92f12109ce524c348a62859af39c4dc9

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Natural Products-Based Drug Design against SARS-CoV-2 Mpro 3CLpro

Autor: Humberto Fonseca de Freitas, Samuel S. R. Pita, Rosivaldo S. Borges, Cleydson B. R. Santos, Njogu M. Kimani, Rai C. Silva, Joaquín M. Campos, Carlos Henrique Tomich de Paula da Silva

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11739, p 11739 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has received global attention due to the serious threat it poses to public health. Since the outbreak in December 2019, millions of people ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f984b23df693c13f49e696d8efffe6d
https://www.mdpi.com/1422-0067/22/21/11739

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Complementary Functions of Plant AP Endonucleases and AP Lyases during DNA Repair of Abasic Sites Arising from C:G Base Pairs

Autor: Dolores Córdoba-Cañero, Marina Jordano-Raya, M Dolores Moreno-Recio, Cristina Beltrán-Melero, Teresa Roldán-Arjona, Rafael R. Ariza, M Isabel Martínez-Macías

Publikováno v: International Journal of Molecular Sciences 22(16), 8763 (2021)
Helvia. Repositorio Institucional de la Universidad de Córdoba
instname
International Journal of Molecular Sciences, Vol 22, Iss 8763, p 8763 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 16

Abasic (apurinic/apyrimidinic, AP) sites are ubiquitous DNA lesions arising from spontaneous base loss and excision of damaged bases. They may be processed either by AP endonucleases or AP lyases, but the relative roles of these two classes of enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e647eec2cc6de5e3b9051779bc81f995
http://hdl.handle.net/10396/21703

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Identification of Potential COX-2 Inhibitors for the Treatment of Inflammatory Diseases Using Molecular Modeling Approaches

Autor: Sebastião Gomes Silva, Joaquín M. Campos, Pedro H F Araújo, Cleydson B. R. Santos, José M Espejo-Román, Ryan da Silva Ramos, Williams Jorge da Cruz Macêdo, Lúcio R de Lima, Jorddy Neves Cruz, Elenilze F B Ferreira

Publikováno v: Molecules, Vol 25, Iss 4183, p 4183 (2020)
Molecules
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Volume 25
Issue 18

Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed in order to avoid the side effects of non-selective inhibitors of COX-1. Thus, the present study aims to identify new selective chemical entities for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871097a6b68ea05d9c0113ec3c201c39
https://www.mdpi.com/1420-3049/25/18/4183

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Functional Variants in NOS1 and NOS2A Are Not Associated with Progressive Hearing Loss in Ménière's Disease in a European Caucasian Population

Autor: Gazquez, Irene, Lopez-Escamez, Jose A., Moreno, Antonia, Campbell, Colleen A., Meyer, Nicole C., Carey, John P., Minor, Lloyd B., Gantz, Bruce J., Hansen, Marlan R., Della Santina, Charles C., Aran, Ismael, Soto-Varela, Andres, Santos, Sofia, Batuecas, Angel, Perez-Garrigues, Herminio, Lopez-Nevot, Alicia, Smith, Richard J.H., Lopez-Nevot, Miguel A.

This is a copy of an article published in the DNA and Cell Biology © 2011 [copyright Mary Ann Liebert, Inc.]; DNA and Cell Biology is available online at: http://online.liebertpub.com. Hearing loss in Meniere's disease (MD) is associated with loss o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2636::082b784fedbe8285cf097d8b1602381d
https://hdl.handle.net/10668/408

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Functional and Transcriptional Induction of Aquaporin-1 Gene by Hypoxia; Analysis of Promoter and Role of Hif-1α

Autor: Ana Paula Bortoletto Martins, Juan José Toledo-Aral, Graça Soveral, Irene Abreu-Rodríguez, Rocío Sánchez Silva, Miriam Echevarría, José López-Barneo

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28385 (2011)
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla

Aquaporin-1 (AQP1) is a water channel that is highly expressed in tissues with rapid O2 transport. It has been reported that this protein contributes to gas permeation (CO2, NO and O2) through the plasma membrane. We show that hypoxia increases Aqp1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb699fa077eda11e52d5281db6f4b56f
https://doi.org/10.1371/journal.pone.0028385

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