Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Phenil J. Patel"'
Autor:
Huyen, Tran, Phenil J, Patel, Aktham, Aburub, Andrea, Sperry, Selina, Estwick, Mohamed E H, ElSayed, Amita Datta, -Mannan
Publikováno v:
Pharmaceutical Research. 39:2555-2567
Oral delivery of therapeutic peptides has been challenging due to multiple physiological factors and physicochemical properties of peptides. We report a systematic approach to identify formulation compositions combining a permeation enhancer and a pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8faa1d5e6ef9a1dbe1752e282c72140
https://doi.org/10.1007/s11095-022-03372-1
https://doi.org/10.1007/s11095-022-03372-1
Autor:
Phenil J. Patel, Marieta Duvnjak Romic, Dipal Patel, Margaret S. Landis, Darren L. Reid, Shobha N. Bhattachar, Wenzhan Yang
Publikováno v:
Drug Discovery Today. 26:713-723
Drug-delivery technologies for modified drug release have been in existence for decades, but their utilization has been largely limited to post-launch efforts improving therapeutic outcomes. Recently, they have gained renewed importance because the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26581814597c35f626a2fb9bc9865bce
https://doi.org/10.1016/j.drudis.2020.12.008
https://doi.org/10.1016/j.drudis.2020.12.008
Autor:
Wenzhan Yang, Phenil J. Patel, Darren L. Reid, Margaret S. Landis, Pankajini Mallick, Dipal Patel, Manuel Sanchez-Felix, Venkata R. Krishnamurthy, Prajakta Gadgil
Publikováno v:
The AAPS journal. 22(2)
The druggability and developability space is rapidly evolving in the post-genomic era. In the past, Lipinski’s rule-of-five (Ro5) emerged and served as a guide for drug-like molecule design for oral delivery in the traditional druggable target spac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e54931b99e8a7668e1a4b093a6687f
https://pubmed.ncbi.nlm.nih.gov/31900602
https://pubmed.ncbi.nlm.nih.gov/31900602
Autor:
Phenil J. Patel, Christopher Breslin, Michael Koenig, Aaron Zettler, Jon Hilden, Aktham Aburub, Allgeier Matthew Carl, Biplob Mitra
Publikováno v:
Journal of Pharmaceutical Innovation. 11:189-199
In pharmaceutical development, powder flow characteristics are notoriously difficult to predict. Although tests exist that aim to determine the flowability of powders, many have not been definitively correlated with a powder’s performance in downst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e0ccf02a2d2e9705af688c4cb9b0438
https://doi.org/10.1007/s12247-016-9258-5
https://doi.org/10.1007/s12247-016-9258-5
Autor:
Bryan D. Smith, Xiwen Ma, Ilaria Conti, Daniel L. Flynn, Yue Webster, Subha Vogeti, Xiaoyi Zhang, Lisa Kays, Robert D. Van Horn, Phenil J. Patel, Youyan Zhang, Gregory P. Donoho, Shih-Hsun Chen, Sean Buchanan, Lawrence Chun, Lysiane Huber, Thomas J. Rutkoski, Tinggui Yin, Vipin Yadav, Denis J. McCann, Igor Mochalkin, Gregory D. Plowman, Henry James Robert, James J. Starling, Jennie L. Walgren, Sheng-Bin Peng, Wei-Ping Lu, Michael Kaufman, Xueqian Gong, Scott C. Wise
Publikováno v:
Cancer Cell. 28:384-398
SummaryLY3009120 is a pan-RAF and RAF dimer inhibitor that inhibits all RAF isoforms and occupies both protomers in RAF dimers. Biochemical and cellular analyses revealed that LY3009120 inhibits ARAF, BRAF, and CRAF isoforms with similar affinity, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379b4cb9cd03085b2f838a879bfaa16a
https://doi.org/10.1016/j.ccell.2015.08.002
https://doi.org/10.1016/j.ccell.2015.08.002
Publikováno v:
Thermochimica Acta. 574:133-139
Characterizing disordered pharmaceutical materials can be challenging, especially materials with partially disordered structures that lose one or two directional order (mesophases) and do not fit the traditional characterization categories of amorpho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e78997093c70ce4b9a8f21a1f4bc4c9
https://doi.org/10.1016/j.tca.2013.10.006
https://doi.org/10.1016/j.tca.2013.10.006
Autor:
Bryan D. Smith, Sheng-Bin Peng, Wei-Ping Lu, Clay Julia Marie, Jeffrey Daniel Cohen, Phenil J. Patel, C. Groshong, Molly M. Hood, Lakshminarayana Vogeti, David Miller, Youyan Zhang, Michael Kaufman, Subha Vogeti, Philip Arthur Hipskind, Wrobleski Aaron D, Xiaoyi Zhang, Yu Mi Ahn, Lisa Kays, Scott C. Wise, Henry James Robert, Danalyn Manglicmot, Timothy M. Caldwell, Sherry Guo, Daniel L. Flynn, Denis J. McCann, Karen Lynn Lobb, David K. Clawson, Cheyenne Logan, Lawrence Chun, Hanumaiah Telikepalli, Jennie L. Walgren, James J. Starling, Thomas J. Rutkoski
Publikováno v:
Journal of medicinal chemistry. 58(10)
The RAS-RAF-MEK-MAPK cascade is an essential signaling pathway, with activation typically mediated through cell surface receptors. The kinase inhibitors vemurafenib and dabrafenib, which target oncogenic BRAF V600E, have shown significant clinical ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68279932802fd22a9e92028eb405e231
https://pubmed.ncbi.nlm.nih.gov/25965804
https://pubmed.ncbi.nlm.nih.gov/25965804
Publikováno v:
Antiviral Research. 29:279-286
The purpose of this study was to carry out an extensive examination of the C∗ concept for prediction of the topical antiviral efficacies of acyclovir (ACV) formulations in a hairless mouse model for the treatment of cutaneous herpes simplex virus t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1719323baf6f47a00b5e1d3a2ce468
https://doi.org/10.1016/0166-3542(96)80225-7
https://doi.org/10.1016/0166-3542(96)80225-7
Publikováno v:
Biochemical and Biophysical Research Communications. 175:407-413
3-Trimethylammoniomethyl catechol and N,N-dimethylepinephrine (catecholine) are redox reactive reagents which possess quaternary ammonium functional groups and the capacity to inhibit or inactivate choline binding macromolecules which mediate choline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8bf79f35ef8ed653516a9e4f195727
https://doi.org/10.1016/0006-291x(91)91579-2
https://doi.org/10.1016/0006-291x(91)91579-2
Autor:
Youyan Zhang, Ilaria Conti, Subha Vogeti, Scott C. Wise, Vipin Yadav, Lisa Kays, Bryan D. Smith, Tinggui Yin, Sheng-Bin Peng, Phenil J. Patel, Wei-Ping Lu, Denis J. McCann, Daniel L. Flynn, Robert D. Van Horn, Henry James Robert, Michael Kaufman, Jennie L. Walgren, Sean Buchanan, Xiaoyi Zhang, James J. Starling, Lysiane Huber
Publikováno v:
Cancer Research. 74:DDT02-02
Mutations in KRas, NRas, BRaf and NF-1 that activate the Ras and mitogen-activated protein kinase (MAPK) pathway are among the most common oncogenic drivers in many cancers, including melanoma, lung, colorectal, and pancreatic cancer. Two BRaf select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13fc22f1533a4789d5637665204e926d
https://doi.org/10.1158/1538-7445.am2014-ddt02-02
https://doi.org/10.1158/1538-7445.am2014-ddt02-02