Zobrazeno 1 - 10
of 614
pro vyhledávání: '"PheWAS"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β (TGF-β) superfamily that has gained considerable attention over the last decade for its observed ability to reverse age-related deteriorati
Externí odkaz:
https://doaj.org/article/62a66bb71f1548c387ed67d6059d52b9
Autor:
Vincent Gardeux, Roel PJ Bevers, Fabrice PA David, Emily Rosschaert, Romain Rochepeau, Bart Deplancke
Publikováno v:
eLife, Vol 12 (2024)
Genome-wide association studies have advanced our understanding of complex traits, but studying how a GWAS variant can affect a specific trait in the human population remains challenging due to environmental variability. Drosophila melanogaster is in
Externí odkaz:
https://doaj.org/article/e8a562e0772941bab3fddb082bbb5545
Autor:
Linda Dieckmann, Marius Lahti-Pulkkinen, Cristiana Cruceanu, Katri Räikkönen, Elisabeth B. Binder, Darina Czamara
Publikováno v:
HGG Advances, Vol 5, Iss 4, Pp 100326- (2024)
Summary: The placenta, a pivotal player in the prenatal environment, holds crucial insights into early developmental pathways and future health outcomes. In this study, we explored genetic molecular regulation in chorionic villus samples (CVS) from t
Externí odkaz:
https://doaj.org/article/9e597dc0ae474854badf7ce27ab81315
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Nonalcoholic fatty liver disease (NAFLD) is the predominant cause of liver pathology. Current evidence highlights plasma proteins as potential therapeutic targets. However, their mechanistic roles in NAFLD remain unclear. This study investig
Externí odkaz:
https://doaj.org/article/2dca0a4189b14e25a6a952fa9b20ec08
Autor:
Yilong Lin, Yue Zhang, Songsong Wang, Lin Cao, Ruidan Zhao, Xilai Ma, Qiaolu Yang, Liyi Zhang, Qingmo Yang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundThe relationship between sodium-glucose cotransporter 2 (SGLT2) inhibitors and prostate cancer is still unknown. Although these inhibitors can influence tumor glycolysis, the underlying mechanism requires further exploration.MethodsA two-sa
Externí odkaz:
https://doaj.org/article/fc1cc124d3c64328b647810b796bc412
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionBasal cell carcinoma (BCC) is the most common skin cancer, lacking reliable biomarkers or therapeutic targets for effective treatment. Genome-wide association studies (GWAS) can aid in identifying drug targets, repurposing existing drugs,
Externí odkaz:
https://doaj.org/article/c48ee8ed9d024e95979716443b5d9632
Autor:
Isabelle M. McGrath, International Endometriosis Genetics Consortium, Grant W. Montgomery, Sally Mortlock
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Endometriosis affects 1 in 9 women, yet it is poorly understood with long diagnostic delays, invasive diagnoses, and poor treatment outcomes. Characterised by the presence of endometrial-like tissue outside of the uterus, its main
Externí odkaz:
https://doaj.org/article/73416742ef144bc2a220cda54d5a25d2
PCSK9 inhibition and broad health outcomes: A Mendelian randomization phenome‑wide association study
Publikováno v:
Pharmacological Research, Vol 203, Iss , Pp 107177- (2024)
Externí odkaz:
https://doaj.org/article/af3aeabf40da43698a78c2958d41d1ca
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Genetic research into atrial fibrillation (AF) and myocardial infarction (MI) has predominantly focused on comparing afflicted individuals with their healthy counterparts. However, this approach lacks granularity, thus overlooking subtleties within p
Externí odkaz:
https://doaj.org/article/14a62a66e3ae4dbe93c574927948ed1e
Autor:
Jacy T. Zanussi, Juan Zhao, Wei-Qi Wei, Gul Karakoc, Cecilia P. Chung, QiPing Feng, Nancy J. Olsen, C. Michael Stein, Vivian K. Kawai
Publikováno v:
BMC Rheumatology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract Background Antinuclear antibodies (ANA) are antibodies present in several autoimmune disorders. However, a large proportion of the general population (20%) also have a positive test; very few of these individuals will develop an autoimmune d
Externí odkaz:
https://doaj.org/article/280a134e6c6c4265ac4f1fd6e3ad3683