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Akademický článek

Driving consistency: CEPI-Centralized Laboratory Network’s conversion factor initiative for SARS-CoV-2 clinical assays used for efficacy assessment of COVID vaccines

Autor: Ali Azizi, Gathoni Kamuyu, Deborah Ogbeni, Philipa Levesque-Damphousse, Daniel Knott, Luc Gagnon, Steven Phay-Tran, Bethan Hussey, Pamela Proud, Sue Charlton, Carolyn Clark, Valentina Bernasconi

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)

ABSTRACTTo date, thousands of SARS-CoV-2 samples from many vaccine developers have been tested within the CEPI-Centralized Laboratory Network. To convert data from each clinical assay to international standard units, the WHO international standard an

Externí odkaz: https://doaj.org/article/a28f551bfb204872bd3ef009fee570e4

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Akademický článek

Standardised quantitative assays for anti-SARS-CoV-2 immune response used in vaccine clinical trials by the CEPI Centralized Laboratory Network: a qualification analysis

Autor: Zala, Vijay, De Almeida, Ana Paula, Fassoulas, Helen, Agrawal, Tanvi, Singh, Janmejay, Roy, Anjan Kumar, Berndsen, Saskia, de Mooij, Marina, Buitendijk, Hester, Stalpers, Coen, Jarju, Modou, Battistella, Filippo, Jeeninga, Rienk, Duijsings, Danny, Razzano, Ilaria, Molesti, Eleonora, Mazzini, Livia, Boccuto, Adele, Holder, Angela, Mee, Edward, Hurley, Matthew, Padley, Jennifer, Rose, Nicola, Gorman, Trina, Vila-Belda, Jose, James, Hannah, Carless, Jerome, Manak, Mark, Gagnon, Luc, Phay-Tran, Steven, Levesque-Damphousse, Philipa, Fabie, Aymeric, Daugan, Matthieu, Khan, Sarwat Tahsin, Proud, Pamela, Hussey, Bethan, Knott, Daniel, Charlton, Sue, Hallis, Bassam, Medigeshi, Guruprasad R, Garg, Neha, Anantharaj, Anbalagan, Raqib, Rubhana, Sarker, Protim, Alam, Mohammad Mamun, Rahman, Mustafizur, Murreddu, Marta, Balgobind, Angela, Hofman, Rick, Grappi, Silvia, Coluccio, Rosa, Calandro, Pierpaolo, Montomoli, Emanuele, Mattiuzzo, Giada, Prior, Sandra, Le Duff, Yann, Page, Mark, Mitchell, Jane, Schwartz, Lauren M, Bartsch, Yannic C, Azizi, Ali, Bernasconi, Valentina

Publikováno v: In The Lancet Microbe March 2024 5(3):e216-e225

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Akademický článek

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Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial

Autor: Scott A Halperin, Lingyun Ye, Donna MacKinnon-Cameron, Bruce Smith, Pedro E Cahn, Guillermo M Ruiz-Palacios, Aamer Ikram, Fernando Lanas, M Lourdes Guerrero, Sergio Raúl Muñoz Navarro, Omar Sued, Dmitry A Lioznov, Vitalina Dzutseva, Ghazala Parveen, Fengcai Zhu, Laura Leppan, Joanne M Langley, Luis Barreto, Jinbo Gou, Tao Zhu, Helen Mao, Luc Gagnon, Steven-Phay Tran, Sarwat Tahsin Khan, Amalia Guadalupe Becerra Aquino, Edgar Eduardo Saldaña Montemayor, Norma Eréndira Rivera Martínez, Víctor Casildo Bohórquez López, J. Abraham Simón Campos, Felipe de Jesús Pineda Cárdenas, Wei Chen, Lihua Hou, Zhe Zhang, Gonzalo Corral, Eduardo López, Ricardo Teijeiro, Maria F. Alzogaray, Cesar Zaidman, Gustavo Lopardo, Bernardo Goecke, Rosa María Feijooó Seoane, Sayed Faisal Mahmood, Ejaz Ahmed Khan, Jayed Akram, Salma Abbas, Naseem Salahuddin, Elena Rozhkova, Tatyana Zubkova

Publikováno v: Lancet (London, England)

Background The Ad5-nCoV vaccine is a single-dose adenovirus type 5 (Ad5) vectored vaccine expressing the SARS-CoV-2 spike protein that was well-tolerated and immunogenic in phase 1 and 2 studies. In this study, we report results on the final efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e238c18adefcfade83a44a479a943715
https://pubmed.ncbi.nlm.nih.gov/35033218

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Interleukin 15-Mediated Induction of Cytotoxic Effector Cells Capable of Eliminating Epstein-Barr Virus-Transformed/Immortalized Lymphocytes in Culture

Autor: Ehsan Sharif-Askari, Ali Ahmad, Phay Tran, Lama M. Fawaz, José Menezes

Publikováno v: JNCI Journal of the National Cancer Institute. 93:1724-1732

Background: Interleukin 15 (IL-15) activates cytotoxic lymphocytes and drives the expansion of memory T cells. Its role in immune control of virus-transformed cells and other tumor cells remains to be elucidated. We investigated the role of IL-15 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804f12cb8c46bb8e1a81611b6694f12b
https://doi.org/10.1093/jnci/93.22.1724

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Modulation of expression of the MHC class I-binding natural killer cell receptors, and NK activity in relation to viral load in HIV-infected/AIDS patients

Autor: Rasheed Ahmad, Sardar Sindhu, Ali Ahmad, Emil Toma, José Menezes, Richard Morisset, Phay Tran

Publikováno v: Journal of Medical Virology. 65:431-440

The natural killer (NK) cells play an important role in viral infections via their spontaneous cytolytic activity against virus-infected cells as well as via secreting a variety of soluble mediators. The MHC class I-binding NK receptors of these cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85325546b523b630d038903aeb8a9c55
https://doi.org/10.1002/jmv.2053

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Host's innate immune response to fungal and bacterial agents in vitro: up-regulation of interleukin-15 gene expression resulting in enhanced natural killer cell activity

Autor: José Menezes, Ali Ahmad, Rasheed Ahmad, Jingwu Xu, Phay Tran

Publikováno v: Immunology. 109(2)

Natural killer (NK) cells play an important role in the first line of defence against viral infections. We have shown earlier that exposure of human peripheral blood mononuclear cells (PBMC) to viruses results in rapid up-regulation of NK cell activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86492ac142d88451819cbb12307070d6
https://pubmed.ncbi.nlm.nih.gov/12757622

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