Zobrazeno 1 - 10
of 7 910
pro vyhledávání: '"Phase I trial"'
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 2729-2743 (2024)
Yuncheng Ni,1,* Ranglang Huang,2,* Shuang Yang,3 Xiao Yan Yang,3 Shan Zeng,3 An Yao,3 Jie Huang,3 Guoping Yang3,4 1Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan, 41001
Externí odkaz:
https://doaj.org/article/0731ec00cbf04a19877b4c875eb00905
Autor:
Alexander Englisch, Clara Hayn, Susanne Jung, Jonas S. Heitmann, Christopher Hackenbruch, Yacine Maringer, Annika Nelde, Marcel Wacker, Monika Denk, Lisa Zieschang, Christine Kammer, Peter Martus, Helmut R. Salih, Juliane S. Walz
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Chronic lymphocytic leukemia (CLL) is the most common form of leukemia among adults in Western countries. Despite the introduction of targeted therapies, including first-line Bruton’s tyrosine kinase inhibitor (BTKi) treatment, CLL remains largely
Externí odkaz:
https://doaj.org/article/dd7432dd452f4e3c895e7e3e1fbf5b55
Autor:
Hongzhong Liu, Qian Zhao, Yuping Yuan, Zhenlei Wang, Teng Wang, Wei Tian, Wen Zhong, Ji Jiang, Shuai Chen, Kai Kong, Chunyan Jin, Pei Hu
Publikováno v:
Infectious Diseases and Therapy, Vol 13, Iss 2, Pp 361-371 (2024)
Abstract Introduction Kukoamine B mesylate (KB) is a mesylate chrysamine B targeting lipopolysaccharides and CpG DNA, two potential treatment targets in sepsis. Methods This first-in-human, randomized, double-blind, placebo-controlled, phase I study
Externí odkaz:
https://doaj.org/article/d3d82916f87748ee83ac320815a6a2d3
Publikováno v:
In ESMO Open July 2024 9(7)
Autor:
Olofsson Bagge, R., Nelson, A., Shafazand, A., Cahlin, C., Carneiro, A., Helgadottir, H., Levin, M., Rizell, M., Ullenhag, G., Wirén, S., Lindnér, P., Nilsson, J.A., Ny, L.
Publikováno v:
In ESMO Open July 2024 9(7)
Autor:
Michael B. Lilly, Chunli Wu, Yu Ke, Wen‐Pin Chen, Adam C. Soloff, Kent Armeson, Noriko N. Yokoyama, Xiaotian Li, Liankun Song, Ying Yuan, Christine E. McLaren, Xiaolin Zi
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 3, Pp n/a-n/a (2024)
Abstract Purpose Our preclinical studies showed that lycopene enhanced the anti‐prostate cancer efficacy of docetaxel in animal models. A phase I trial (NCT0149519) was conducted to identify an optimum dose of synthetic lycopene in combination with
Externí odkaz:
https://doaj.org/article/5c65eef1c6c54d5eaf06f95c1a59df0d
Autor:
Kyrillus S. Shohdy, Manon Pillai, Ryan Guest, Dominic Rothwell, Natalia Kirillova, Shien Chow, David Gilham, Fiona Thistlethwaite, Robert Hawkins
Publikováno v:
eJHaem, Vol 4, Iss 3, Pp 882-885 (2023)
Abstract The persistence and reactivity of CAR T cells were enhanced by adding co‐stimulatory domains, which is the basis of currently approved CAR‐T cell therapies. However, this comes at the expense of increasing toxicities from the strong cyto
Externí odkaz:
https://doaj.org/article/f080ad1392f64c9c93c2ca458278ac2c
Autor:
Ma J, Huang J, Zou C, Wu Q, Xie J, Zhang X, Yang X, Yang S, Wu Z, Jiang Y, Yu S, Yang G, Li M
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 17, Pp 2303-2313 (2023)
Junlong Ma,1,2,* Jie Huang,1,* Chan Zou,1 Qian Wu,1 Jinlian Xie,1 Xingfei Zhang,1 Xiaoyan Yang,1 Shuang Yang,1 Ziteng Wu,3 Yan Jiang,3 Sen Yu,3 Xuqing Zhang,4 Guoping Yang,1,5 Mingyuan Li1 1The Third Xiangya Hospital, Central South University
Externí odkaz:
https://doaj.org/article/175df61c3eb84287877a9bce32f1c83d
Autor:
Cheng-Hung How, Pei-Hsing Chen, Yu-Ching Chen, Yong-Chong Lin, Ke-Cheng Chen, Jin-Shing Chen, Tai-Horng Young
Publikováno v:
Frontiers in Surgery, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/39231fecbca9463da828596e664ea3df
Autor:
Cheng-Hung How, Pei-Hsing Chen, Yu-Ching Chen, Yong-Chong Lin, Ke-Cheng Chen, Jin-Shing Chen, Tai-Horng Young
Publikováno v:
Frontiers in Surgery, Vol 11 (2024)
Background/purposeBiomaterial-based implants are gaining traction as an option for pleurodesis treatment, yet the search for the best biomaterial or the most suitable shape to handle spontaneous pneumothorax continues. This forward-looking research a
Externí odkaz:
https://doaj.org/article/372df994ba874570bf0ae45ed1b9ba37