Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Pharmakologie, Therapeutik"'
Autor:
Yomna M. Nassar, Nicolas Hohmann, Robin Michelet, Katharina Gottwalt, Andreas D. Meid, Jürgen Burhenne, Wilhelm Huisinga, Walter E. Haefeli, Gerd Mikus, Charlotte Kloft
Publikováno v:
Clinical Pharmacokinetics. 61:1595-1607
Background Cytochrome P450 (CYP) 3A contributes to the metabolism of many approved drugs. CYP3A perpetrator drugs can profoundly alter the exposure of CYP3A substrates. However, effects of such drug-drug interactions are usually reported as maximum e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9bef93b53ad2502c15c807e73aec31
https://doi.org/10.1007/s40262-022-01175-6
https://doi.org/10.1007/s40262-022-01175-6
Autor:
Hubing, Sascha
Die vorliegende Arbeit beschäftigt sich generell mit der Entwicklung von Gentherapeutischen Transfektionssystemen mit dem vorrangigen Ziel die Behandlungsmöglichkeiten bei Tumorerkrankungen zu optimieren und auszubauen. Durch die Weiterentwicklung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1b1120f0713401c7b69be74eafa26e
Autor:
Lea Marie Schatz, Alexander Brinkmann, Anka Röhr, Otto Frey, Sebastian Greppmair, Ferdinand Weinelt, Michael Zoller, Christina Scharf, Georg Hempel, Uwe Liebchen
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
The altered pharmacokinetics of renally cleared drugs such as meropenem in critically ill patients receiving continuous renal replacement therapy (CRRT) might impact target attainment. Model-informed precision dosing (MIPD) is applied to individualiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daef6d0273865b55305cecb5562d6a48
https://doi.org/10.1128/aac.00104-23
https://doi.org/10.1128/aac.00104-23
Autor:
Yang, Yiling
Natural products have high structural diversity with various pharmacological or biological activities, which are of great significance to our life and drug research. Millions of natural products with versatile structural diversity have been found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178293549cb11ebca0e4401c0a463dec
Autor:
Viktoria Stachanow, Uta Neumann, Oliver Blankenstein, Nele Alder-Baerens, Davide Bindellini, Peter Hindmarsh, Richard J. Ross, Martin J. Whitaker, Johanna Melin, Wilhelm Huisinga, Robin Michelet, Charlotte Kloft
Publikováno v:
Pharmaceuticals; Volume 16; Issue 3; Pages: 464
Monitoring cortisol replacement therapy in congenital adrenal hyperplasia (CAH) patients is vital to avoid serious adverse events such as adrenal crises due to cortisol underexposure or metabolic consequences due to cortisol overexposure. The less in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f6e0bd6c59c50394e132e9d8500a37
Autor:
Xiang, Pan
Secondary metabolites, a special class of natural products, generally display significant biological activities in organisms, especially those from plants, bacteria, and fungi. For example, diverse natural products with remarkable structures have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cc6b766431ed1bdc840682208e43bc
Autor:
Redlin, Fabian
G-Protein-gekoppelte Rezeptoren (GPCRs) stellen die größte Gruppe von Transmembranrezeptoren im menschlichen Körper und erfüllen unzählige physiologische Aufgaben. Die drei RH-RhoGEFs (GEF=GTP-Austauschfaktor) p115-RhoGEF, LARG (leukemia-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde4a6f21f57631613744c8e6fb51365
Publikováno v:
British Journal of Pharmacology.
Background and Purpose All previous rodent models lacking the peptide hormone angiotensin II (Ang II) were hypotensive. A mixed background strain with global deletion of the angiotensinogen gene was backcrossed to the FVB/N background (Agt-KO), a str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09235336e6abb33c0868a865fdeb3bd7
https://doi.org/10.1111/bph.16051
https://doi.org/10.1111/bph.16051
Autor:
Harken, Lauritz Christian
Cyclodipeptides (CDPs) with a 2,5-diketopiperazine (DKP) as central core occur ubiquitously in living organisms, from simple bacteria and fungi to more complex ones like plants and animals. They display various biological and pharmacological effects,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233b1bf46460384f0168a9fb0683c970
Autor:
Robin Michelet, Davide Bindellini, Johanna Melin, Uta Neumann, Oliver Blankenstein, Wilhelm Huisinga, Trevor N. Johnson, Martin J. Whitaker, Richard Ross, Charlotte Kloft
Publikováno v:
Frontiers in Pharmacology. 13
Introduction: Hydrocortisone is the standard of care in cortisol replacement therapy for congenital adrenal hyperplasia patients. Challenges in mimicking cortisol circadian rhythm and dosing individualization can be overcome by the support of mathema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1773358fc5f34da828ae6b26cec3151e
https://doi.org/10.3389/fphar.2022.1090554
https://doi.org/10.3389/fphar.2022.1090554