Zobrazeno 1 - 10
of 1 892
pro vyhledávání: '"Pharmacophore modeling"'
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract The performance of molecular docking can be improved by comparing the shape similarity of the flexibly sampled poses against the target proteins’ inverted binding cavities. The effectiveness of these pseudo-ligands or negative image-based
Externí odkaz:
https://doaj.org/article/3cd64d458d6d431f9c13a1b837e2cf8f
Autor:
Noor Bahadar, Sher Bahadar, Abdul Sajid, Muqeet Wahid, Ghadir Ali, Abdullah Alghamdi, Hakeem Zada, Tamreez Khan, Shafqat Ullah, Qingjia Sun
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-17 (2024)
Abstract The protein Bcl-2, well-known for its anti-apoptotic properties, has been implicated in cancer pathogenesis. Identifying the primary gene responsible for promoting improved cell survival and development has provided compelling evidence for p
Externí odkaz:
https://doaj.org/article/81a1613b6fef454daadbaaa30dd0dd4d
Autor:
Yanfeng Liu, Liangying Deng, Feng Ding, Qiang Wang, Shuran Zhang, Nana Mi, Wenhui Zhang, Bailin Zeng, Huangjin Tong, Lixing Wu
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-16 (2024)
Abstract Cholesteryl ester transfer protein (CETP) is a promising therapeutic target for cardiovascular diseases. It effectively lowers the low-density lipoprotein cholesterol levels and increases the high-density lipoprotein cholesterol levels in th
Externí odkaz:
https://doaj.org/article/90fb942c79524cd19977b7e84f3fe01a
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 4, Pp 3394-3407 (2024)
Nowadays, the explosion of knowledge in the field of epigenetics has revealed new pathways toward the treatment of multifactorial diseases, rendering the key players of the epigenetic machinery the focus of today’s pharmaceutical landscape. Among e
Externí odkaz:
https://doaj.org/article/1ab3cbce331749c5aaf50fe2852b2fbb
Publikováno v:
Cancer Medicine, Vol 13, Iss 15, Pp n/a-n/a (2024)
Abstract Background Breast cancer, a leading cause of female mortality, is closely linked to mutations in estrogen receptor beta (ESR2), particularly in the ligand‐binding domain, which contributed to altered signaling pathways and uncontrolled cel
Externí odkaz:
https://doaj.org/article/ce55b163e9354b79b8b0270fc9073fe8
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-28 (2024)
Abstract In the current study we suggest a novel approach to curb non-alcoholic steatohepatitis (NASH) progression, and we suggest privileged scaffolds for the design of novel compounds for this aim. NASH is an advanced form of non-alcoholic fatty li
Externí odkaz:
https://doaj.org/article/82e08e6c83ee4375ab8dbf2e4eb6e07b
Autor:
Rahul D. Jawarkar, Suraj N. Mali, Rahul G. Ingle, Sami A. Al-Hussain, Aamal A. Al-Mutairi, Prashant Deshmukh, Magdi E.A. Zaki
Publikováno v:
Chemical Physics Impact, Vol 9, Iss , Pp 100720- (2024)
Many human disorders include NF-kB signaling pathways, making IKK a therapeutic target in cancer treatment. Inflammatory illnesses and cancer are examples. COVID-19 is one of several triggers that stimulate NF-kB signaling. The activation of the NF-k
Externí odkaz:
https://doaj.org/article/a898a66ef6604217b85a49b0410a810a
Publikováno v:
Artificial Intelligence Chemistry, Vol 2, Iss 1, Pp 100039- (2024)
Artificial intelligence (AI) is revolutionizing the current process of drug design and development, addressing the challenges encountered in its various stages. By utilizing AI, the efficiency of the process is significantly improved through enhanced
Externí odkaz:
https://doaj.org/article/f7e43313bd724c06a4533c4957ed7260
Autor:
Alzain Abdulrahim A., Elbadwi Fatima A., Al-Karmalawy Ahmed A., Elhag Rashid, Osman Wadah, Mothana Ramzi A.
Publikováno v:
Open Chemistry, Vol 21, Iss 1, Pp 31736-44 (2023)
Human neutrophil elastase (HNE) plays a crucial role in causing tissue damage in various chronic and inflammatory disorders, making it a target for treating inflammatory diseases. While some inhibitors of HNE’s activity have been identified, only a
Externí odkaz:
https://doaj.org/article/11fb72d28f03420b9b2722b895682199
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 935 (2024)
SHP2 belongs to a cytoplasmic non-receptor protein tyrosine phosphatase class. It plays a critical role in the development of various cancers, such as gastric cancer, leukemia, and breast cancer. Thus, SHP2 has gained the interest of researchers as a
Externí odkaz:
https://doaj.org/article/bcda4d93d7714c6b8b65e9482fd207da