Zobrazeno 1 - 10
of 4 004
pro vyhledávání: '"Pharmacology and Toxicology"'
Publikováno v:
Journal of Cannabis Research, Vol 6, Iss 1, Pp 1-10 (2024)
Abstract Background Cannabis has been shown to impact driving due to changes produced by delta-9-tetrahydrocannabinol (THC), the psychoactive component of cannabis. Current legal thresholds for blood THC while driving are based predominantly on evide
Externí odkaz:
https://doaj.org/article/cefd1ef1f9bc4f789c8b8838c9e2f062
Autor:
Mao Yutong, Ye Liang, Sha Chunjie, Guan Xiaolin, Gong Xiaoyan, Dong Lin, Du Guangying, Zhang Xuemei, Cen Xiaobo, Tian Jingwei, Yu Pengfei, Wang Hongbo
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
LY01005 is an investigational new drug product of goserelin acetate which is formulated as extended-release microspheres for intramuscular injection. To support the proposed clinical trials and marketing application of LY01005, pharmacodynamics, phar
Externí odkaz:
https://doaj.org/article/a58305d399ad40deb546edb58cb7ed52
Akademický článek
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Autor:
Hinojosa, M. G., Johansson, Y., Cediel Ulloa, Andrea, Ivanova, E., Gabring, N., Gliga, A., Forsby, A.
Publikováno v:
NeuroToxicology. 97:65-77
Current guidelines for developmental neurotoxicity (DNT) evaluation are based on animal models. These have limitations so more relevant, efficient and robust approaches for DNT assessment are needed. We have used the human SH-SY5Y neuroblastoma cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e32b39e075ff6299b782239236ec14
https://doi.org/10.1016/j.neuro.2023.05.011
https://doi.org/10.1016/j.neuro.2023.05.011
Autor:
Alhariri, Batul
Bakgrund: Det har visat sig under de senaste 20 åren att användning av aripiprazol ökar risken för spel- och impulskontrollstörningar. Aripiprazol är ett första generationens antipsykotiska läkemedel och fungerar som en partiell serotonin 5-H
Externí odkaz:
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-522791
Publikováno v:
Pharmacogenomics and Personalized Medicine. 16:449-461
Background: Sub-Saharan Africa (SSA) population is genetically diverse and heterogenous thus variability in drug response among individuals is predicted to be high. Cytochrome P450 (CYP450) polymorphisms is a major source of variability in drug respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b236f2d4dac2b8220866c1d99fc5742d
https://doi.org/10.2147/pgpm.s379945
https://doi.org/10.2147/pgpm.s379945
Publikováno v:
Trends in Biochemical Sciences. 48:321-330
The concept of the histone code posits that histone modifications regulate gene functions once interpreted by epigenetic readers. A well-studied case is trimethylation of lysine 4 of histone H3 (H3K4me3), which is enriched at gene promoters. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384a1440d49f456b6b5df9e24c2abe85
https://doi.org/10.1016/j.tibs.2022.10.003
https://doi.org/10.1016/j.tibs.2022.10.003
Akademický článek
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Autor:
Katja Häkkinen, Wilma Kiander, Heidi Kidron, Markku Lähteenvuo, Lea Urpa, Jonne Lintunen, Kati-Sisko Vellonen, Seppo Auriola, Minna Holm, Kaisla Lahdensuo, Olli Kampman, Erkki Isometsä, Tuula Kieseppä, Jouko Lönnqvist, Jaana Suvisaari, Jarmo Hietala, Jari Tiihonen, Aarno Palotie, Ari V. Ahola-Olli, Mikko Niemi
Publikováno v:
Molecular Pharmaceutics. 20:1500-1508
Variants in the SLCO1B1 (solute carrier organic anion transporter family member 1B1) gene encoding the OATP1B1 (organic anion transporting polypeptide 1B1) protein are associated with altered transporter function that can predispose patients to adver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a93e8cfd6ae6cf7cd04c598bc0ca94d
https://doi.org/10.1021/acs.molpharmaceut.2c00715
https://doi.org/10.1021/acs.molpharmaceut.2c00715