Zobrazeno 1 - 10 of 70 pro vyhledávání: '"Pharmacology/Drug Interactions"'
1
Pre-emptive analgesic efficacy of tramadol compared with morphine after major abdominal surgery
Autor: Yasemin Güneş, Hakkı Ünlügenç, T. Guler, M. Ozalevli, Geylan Isik
Publikováno v: British Journal of Anaesthesia. 91:209-213
PubMedID: 12878619 Background. Studies of pre-emptive analgesia in humans have shown conflicting results. This prospective, randomized, double-blind, controlled study was designed to test the hypothesis that a reduction in postoperative morphine cons
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7a0cd0704fc4c7f6a4512ab6dc453e
https://doi.org/10.1093/bja/aeg163
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2
Activities of rifampin, Rifapentine and clarithromycin alone and in combination against mycobacterium ulcerans disease in mice
Autor: Eric L. Nuermberger, Kelly E. Dooley, Paul J. Converse, Deepak V. Almeida, Zahoor Ahmad, Jacques H. Grosset
Publikováno v: PLoS Neglected Tropical Diseases, Vol 5, Iss 1, p e933 (2011)
PLoS Neglected Tropical Diseases
Background Treatment of Mycobacterium ulcerans disease, or Buruli ulcer (BU), has shifted from surgery to treatment with streptomycin(STR)+rifampin(RIF) since 2004 based on studies in a mouse model and clinical trials. We tested two entirely oral reg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68af3eaeaca26f96302eb8ec937940d6
http://europepmc.org/articles/PMC3014976?pdf=render
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3
The Bile Acid Sensor FXR Protects against Dyslipidemia and Aortic Plaques Development Induced by the HIV Protease Inhibitor Ritonavir in Mice
Autor: Giuseppe Palladino, Daniela Francisci, Sabrina Cipriani, Andrea Mencarelli, Franco Baldelli, Stefano Fiorucci, Eleonora Distrutti, Barbara Renga
Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 10, p e13238 (2010)
BACKGROUND: Although human immunodeficiency virus (HIV)-related morbidity and mortality rates in patients treated with a combination of high active antiretroviral therapy (HAART) have declined, significant metabolic/vascular adverse effects associate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82040e2f5be0de5d83870ddf632364c
http://europepmc.org/articles/PMC2951893
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4
Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase
Autor: Tomas C. Bellamy, Heidi C.E. Welch, Claire Jackson
Publikováno v: PLoS ONE, Vol 5, Iss 8, p e11962 (2010)
PLoS ONE
Background Long-term potentiation (LTP) at the parallel fibre–Purkinje cell synapse in the cerebellum is a recently described and poorly characterized form of synaptic plasticity. The induction mechanism for LTP at this synapse is considered recipr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c332e3cb1627dd4c84be332d262596
http://europepmc.org/articles/PMC2915919?pdf=render
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5
Binding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurements
Autor: Enrico, Defranchi, Enrico, De Franchi, Claire, Schalon, Mirko, Messa, Franco, Onofri, Fabio, Benfenati, Didier, Rognan
Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12214 (2010)
Predicting off-targets by computational methods is getting increasing importance in early drug discovery stages. We herewith present a computational method based on binding site three-dimensional comparisons, which prompted us to investigate the cros
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448f4d714307bcf437f22049411dce31
https://pubmed.ncbi.nlm.nih.gov/20808948
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6
Protein folding activity of ribosomal rna is a selective target of two unrelated antiprion drugs
Autor: Raimon Sabaté, Chenhui Huang, Déborah Tribouillard-Tanvier, Suzana Dos Reis, Didier Vilette, Hervé Galons, Cécile Voisset, Nathalie Desban, Vincent Béringue, Marc Blondel, Suparna Sanyal, Stéphane Bach, Jean-Yves Thuret, Nicolas Talarek, Fabienne Gug, Ema Kikovska, Stéphane Chédin, Surachai Supattapone, Sven J. Saupe
Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2008, 3 (5), pp.e2174. ⟨10.1371/journal.pone.0002174⟩
PLoS ONE, 2008, 3 (5), pp.e2174. ⟨10.1371/journal.pone.0002174⟩
PLoS ONE, Public Library of Science, 2008, 3 ((5)), pp.e2174
PLoS ONE, Vol 3, Iss 5, p e2174 (2008)
Plos One 5 (3), . (2008)
International audience; BACKGROUND: 6-Aminophenanthridine (6AP) and Guanabenz (GA, a drug currently in use for the treatment of hypertension) were isolated as antiprion drugs using a yeast-based assay. These structurally unrelated molecules are also
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e3304ea9e13c9329b3a4e632f3c323
http://doc.rero.ch/record/18086/files/tal_pfa.pdf
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7
Therapeutic efficacy of human hepatocyte transplantation in a SCID/uPA mouse model with inducible liver disease
Autor: David Bond, D. Lorne Tyrrell, Jamie T. Lewis, Banu Sis, Norman M. Kneteman, Toshiyasu Kawahara, Donna N. Douglas, Karl P. Fischer
Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9209 (2010)
PLoS ONE
Background Severe Combined Immune Deficient (SCID)/Urokinase-type Plasminogen Activator (uPA) mice undergo liver failure and are useful hosts for the propagation of transplanted human hepatocytes (HH) which must compete with recipient-derived hepatoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40ee5db055cf18a6d9c26b3ad943147
http://europepmc.org/articles/PMC2823785?pdf=render
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8
Evaluation of Oxfendazole, Praziquantel and Albendazole against Cystic Echinococcosis: A Randomized Clinical Trial in Naturally Infected Sheep
Autor: Eduardo A. Barron, Monica Llamosas, Armando E. Gonzalez, Robert H. Gilman, Cesar M. Gavidia, Manuela Verastegui, Berenice Ninaquispe, Colin L Robinson
Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 4, Iss 2, p e616 (2010)
Background Cystic Echinococosis (CE) is a zoonotic disease caused by larval stage Echinococcus granulosus. We determined the effects of high dose of Oxfendazole (OXF), combination Oxfendazole/Praziquantel (PZQ), and combination Albendazole (ABZ)/Praz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c60cb647cc59cf983619d331e1d618
http://europepmc.org/articles/PMC2826409
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9
A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways
Autor: Navdeep Jaitly, Izhar Wallach, Ryan H. Lilien
Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12063 (2010)
PLoS ONE
Adverse drug reactions (ADR), also known as side-effects, are complex undesired physiologic phenomena observed secondary to the administration of pharmaceuticals. Several phenomena underlie the emergence of each ADR; however, a dominant factor is the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ecfc41902c93c2780770b2213314a4
http://europepmc.org/articles/PMC2925884?pdf=render
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10
Synergistic and additive effects of epigallocatechin gallate and digitonin on Plasmodium sporozoite survival and motility
Autor: Sylvia Münter, Janina Kristin Hellmann, Michael Wink, Friedrich Frischknecht
Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8682 (2010)
PLoS ONE
BackgroundMost medicinal plants contain a mixture of bioactive compounds, including chemicals that interact with intracellular targets and others that can act as adjuvants to facilitate absorption of polar agents across cellular membranes. However, l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045f85d2cecc632b2a2bd677e5ea5d23
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20072627/pdf/?tool=EBI
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