Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Pharmacokinetics: Excretion"'
Autor:
Qianlei Wang, Ning Xiao, Zhengkun Xu, Chun Wang, Feng Xiao, Jiajie Kuai, Jinzhang Gao, Wei Wei
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 130:364-374
Paeoniflorin-6'-O-benzene sulfonate (CP-25) is a novel ester derivative of paeoniflorin, which has been shown to have synergistic pharmacodynamic effects with leflunomide (LEF). To determine the effects of CP-25 on the pharmacokinetics of LEF in rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8cc496226b3b3f005e3c631274fa4c
https://doi.org/10.1111/bcpt.13685
https://doi.org/10.1111/bcpt.13685
Publikováno v:
European Journal of Pharmaceutical Sciences. 130:11-20
The covalent binding of proteins with polyethylene glycol (PEG) molecules is a valuable tool to extend the half-life of many biotherapeutics, including factor VIII (FVIII) products to treat patients with haemophilia A. Although PEG has low toxicity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e0b657759ec7a2e2592e90928bbac6
https://doi.org/10.1016/j.ejps.2019.01.015
https://doi.org/10.1016/j.ejps.2019.01.015
Autor:
Teresa Fuller, Claire Ambery, Adam Hughes, Adrian Pereira, Graeme Young, Aili L. Lazaar, David Ramsay, Peter T. Daley-Yates, Frans van den Berg
Publikováno v:
Clinical Pharmacology in Drug Development
Clin Pharmacol Drug Dev
Clin Pharmacol Drug Dev
Inhaled batefenterol is an investigational bifunctional molecule for the treatment of chronic obstructive pulmonary disease. The excretion balance and pharmacokinetics of batefenterol using [14C]‐radiolabeled drug administered orally and as intrave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8204b326435ff7eb8db2bed6108951
http://europepmc.org/articles/PMC6282586
http://europepmc.org/articles/PMC6282586
Publikováno v:
Food and Chemical Toxicology. 109:552-568
The pharmacokinetics, excretion balance, and tissue distribution of [14C]-labeled glycolipids from Dacryopinax spathularia (herein referred to as “AM-1”) and [14C]-LCFA equivalents following single or repeated administration to Sprague Dawley rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ae98a77dd90009b77d461d08d242fa8
https://doi.org/10.1016/j.fct.2017.08.038
https://doi.org/10.1016/j.fct.2017.08.038
Publikováno v:
Open Forum Infectious Diseases
Background Rezafungin is a once-weekly novel echinocandin antifungal currently in Phase 3 development for treatment of candidemia and invasive candidiasis (ReSTORE) and for prevention of invasive fungal disease caused by Candida, Aspergillus, and Pne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd7d9546329e6c50e92715a951e7401
http://europepmc.org/articles/PMC7776356
http://europepmc.org/articles/PMC7776356
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
Zoliflodacin is a novel spiropyrimidinetrione with activity against bacterial type II topoisomerases that inhibits DNA biosynthesis and results in accumulation of double-strand cleavages in bacteria. We report results from two phase 1 studies that in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bbd10cb55816a160cf572a4420e5cf
https://doi.org/10.1128/aac.01808-18
https://doi.org/10.1128/aac.01808-18
Publikováno v:
Biomedical Chromatography. 29:1581-1588
A sensitive ultrahigh performance liquid chromatography tandem mass spectrometry (UHPLC-MS) method was developed for determination of gambogic acid (GA) in rat plasma, urine, bile and main tissues. GA was separated on an Agilent Zorbax XDB–C18 colu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b596394a9cd41ffe6bd351903ba31033
https://doi.org/10.1002/bmc.3462
https://doi.org/10.1002/bmc.3462
Publikováno v:
Molecular Medicine Reports
DL0410, a dual-action cholinesterase inhibitor and histamine-3 receptor antagonist with a novel structural scaffold, may be a potential candidate for the treatment of Alzheimer's disease (AD). To the best of the authors' knowledge, this is the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512962c00a53281985c8558bb7746cd3
https://pubmed.ncbi.nlm.nih.gov/31173186
https://pubmed.ncbi.nlm.nih.gov/31173186
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 132
Berberine (BBR) is a bioactive plant ingredient derived from the roots and bark of Berberis aristata and Coptis chinensis and has a wide variety of pharmacological effects. 8-cetylberberine (8-BBR-C16) is the berberine (BBR) derivative reconstructed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8627012c8dffe5a767d68b4eb3a2959a
https://pubmed.ncbi.nlm.nih.gov/27750103
https://pubmed.ncbi.nlm.nih.gov/27750103
Autor:
Ihor Bekersky, Robert M. Fielding, Donald N. Buell, Dawna E. Dressler, Thomas J. Walsh, Sandra Kline
Publikováno v:
Journal of Clinical Pharmacology. 41:963-971
Amphotericin B (AmB) in small unilamellar liposomes (AmBisome) provides higher plasma concentrations and greater safety than the conventional deoxycholate formulation. The authors compared the disposition of the liposome's drug and cholesterol compon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d65909bb8c203f821068e9ac72d9e64d
https://doi.org/10.1177/00912700122010942
https://doi.org/10.1177/00912700122010942