Zobrazeno 1 - 10
of 43 908
pro vyhledávání: '"Pharmacokinetic"'
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-18 (2024)
Abstract Background Cancer and diabetes mellitus are quite common diseases found together worldwide. A considerable amount of evidence is available for the rapid development and presentation of various types of cancer in the type 2 diabetes mellitus
Externí odkaz:
https://doaj.org/article/7d72ca7677a84a0eadd6b98320b93e6a
Autor:
Said Rammali, Abderrazak Idir, Marouane Aherkou, Alin Ciobică, Fatima Zahra Kamal, Mohamed El Aalaoui, Abdellatif Rahim, Abdelkrim khattabi, Zyad Abdelmajid, Abderrahim Aasfar, Vasile Burlui, Gabriela Calin, Ioannis Mavroudis, Bouchaib Bencharki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract This study aimed to explore the antioxidant potential of the ethyl acetate extract of Streptomyces coeruleofuscus SCJ strain, along with its inhibitory effects on the triple-negative human breast carcinoma cell line (MDA-MB-468). The ethyl a
Externí odkaz:
https://doaj.org/article/65070100696a40faa393e7550aa66617
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-11 (2024)
Abstract Ectoine (ECT) has recently gained considerable interest in the healthcare sector due to its promising therapeutic benefits in a variety of human disorders. This research aimed to quantify the ECT plasma level in rats by creating and optimizi
Externí odkaz:
https://doaj.org/article/13e0e4afa8624cbfb5e9e08788d0e46b
Publikováno v:
Indonesian Journal of Chemistry, Vol 24, Iss 5, Pp 1541-1555 (2024)
Several 2-phenoxyacetic acid derivatives and their isosteres were synthesized in moderate to high yield (57–96%) for searching newer and safer alternatives to these existing anti-inflammatory agents. The compounds were characterized by 1H-NMR, 13C-
Externí odkaz:
https://doaj.org/article/3ba6231a2e1d4ab1960d9af72ecb2c9f
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract The aim of this work is to develop and evaluate self-nanoemulsifying drug delivery systems (SNEDDS) containing simvastatin to increase its oral bioavailability. Formulation EO 5 (Ethyl oleate 9.3% w/w: Tween 80 49.4% w/w: Propylene glycol 39
Externí odkaz:
https://doaj.org/article/bea312165dee4bd0982f5993d923b4b5
Autor:
Nada Abla, Anne Claire Marrast, Elodie Jambert, Naomi Richardson, Stephan Duparc, Lisa Almond, Karen Rowland Yeo, Xian Pan, Joel Tarning, Ping Zhao, Janice Culpepper, Catriona Waitt, Charlotte Koldeweij, Susan Cole, Andrew S. Butler, Sonia Khier, Jörg J. Möhrle, Myriam El Gaaloul
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Plasmodium vivax malaria remains a global health challenge, with approximately 6.9 million estimated cases in 2022. The parasite has a dormant liver stage, the hypnozoite, which reactivates to cause repeated relapses over weeks, months, or y
Externí odkaz:
https://doaj.org/article/45b60ab3d99845c694b1be738e16f7c1
Autor:
Danielle A. Mzyk, Jennifer L. Halleran, Hannah J. Sylvester, Claire B. Giles, Megan E. Jacob, Ronald E. Baynes, Derek M. Foster
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 38, Iss 5, Pp 2814-2822 (2024)
Abstract Background Pharmacological activity of intramammary drugs depends on adequate drug concentrations within the cistern, but sampling is often limited. Insight into the active drug concentration within the mammary cistern may assist in determin
Externí odkaz:
https://doaj.org/article/d894944127e54acf9ce14a69a203d12b
Autor:
Carolina V. Alexander‐Savino, Adam Rumage, Christopher Pullion, Richard Straube, Christopher J. Schaber, Elaine S. Gilmore, Brian Poligone
Publikováno v:
JEADV Clinical Practice, Vol 3, Iss 4, Pp 1109-1118 (2024)
Abstract Background HyBryteTM is a photodynamic therapy of topical hypericin that has recently been shown to be safe and efficacious in early stage cutaneous T‐cell lymphoma (CTCL). However, its efficacy, absorption, and effect on heart function pa
Externí odkaz:
https://doaj.org/article/a1abaf9268984d1cb9eb156a1bf08dd9
Autor:
Lin Zijin, Liu Xiaodong
Publikováno v:
Guoji Yanke Zazhi, Vol 24, Iss 9, Pp 1408-1415 (2024)
Vision is closely tied to quality of life. Traditional drug delivery routes for clinical therapy of key ocular diseases, such as glaucoma, are topical and systemic administrations, which are less invasive but often face some physiological barriers su
Externí odkaz:
https://doaj.org/article/6e63fe7514564999804d4b1e97a36d9b
Autor:
Xingchen Bian, Nanyang Li, Yi Li, Xu Zhu, Jicheng Yu, Yingying Hu, Haijing Yang, Qiong Wei, Xiaojie Wu, Jingjing Wang, Guoying Cao, Jufang Wu, Yang Wang, Jing Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
PurposeLefamulin is the first pleuromutilin antibiotic approved for the treatment of community-acquired bacterial pneumonia (CABP). However, the pharmacokinetic/pharmacodynamic (PK/PD) characteristics in Chinese CABP patients are not fully understood
Externí odkaz:
https://doaj.org/article/a1fb503cba054be4a4f4064aad7ab455