Výsledky vyhledávání - "Pharmaco-fUS"

Akademický článek

Pharmaco-fUS for Characterizing Drugs for Alzheimer’s Disease – The Case of THN201, a Drug Combination of Donepezil Plus Mefloquine

Autor: Benjamin Vidal, Marine Droguerre, Marco Valdebenito, Luc Zimmer, Michel Hamon, Franck Mouthon, Mathieu Charvériat

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer’s disease (AD). Beyond the widely described neuronal impact of donepezil, it was recently shown that targeting connexins, the

Externí odkaz: https://doaj.org/article/f1673f49cb2843cbbeed8d10c46d6f94

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Akademický článek

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Akademický článek

Pharmaco-fUS: Quantification of pharmacologically-induced dynamic changes in brain perfusion and connectivity by functional ultrasound imaging in awake mice

Autor: Claire Rabut, Jérémy Ferrier, Adrien Bertolo, Bruno Osmanski, Xavier Mousset, Sophie Pezet, Thomas Deffieux, Zsolt Lenkei, Mickaël Tanter

Publikováno v: NeuroImage, Vol 222, Iss , Pp 117231- (2020)

There is a critical need for reliable quantitative biomarkers to assess functional brain alterations in mouse models of neuropsychiatric diseases, but current imaging methods measuring drug effects through the neurovascular coupling, face issues incl

Externí odkaz: https://doaj.org/article/66893aa50ebc4b56a69187ffe242a5a2

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Functional ultrasound imaging to study brain dynamics: Application of pharmaco-fUS to atomoxetine

Autor: Marco Valdebenito, Ludovic Venet, Benjamin Vidal, Mathieu Charvériat, Luc Zimmer, Marine Droguerre, Franck Mouthon

Publikováno v: Neuropharmacology
Neuropharmacology, Elsevier, 2020, 179, pp.108273. ⟨10.1016/j.neuropharm.2020.108273⟩

International audience; Highlights• A first evaluation of the potential of fUS during a pharmacological challenge.• ATX modulates cerebral blood volume in areas associated with visual processing.• fUS as a new step to move forwards new drugs to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb566798b5ed9e3007a349cd26d2558
https://pubmed.ncbi.nlm.nih.gov/32801025

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Pharmaco-fUS in cognitive impairment: Lessons from a preclinical model

Autor: Benjamin Vidal, Mickaël Pereira, Marco Valdebenito, Louis Vidal, Franck Mouthon, Luc Zimmer, Mathieu Charvériat, Marine Droguerre

Publikováno v: Journal of psychopharmacology (Oxford, England). 36(11)

Background: There is an urgent need to understand and reverse cognitive impairment. The lack of appropriate animal models combined with the limited knowledge of pathophysiological mechanisms makes the development of new cognition-enhancing drugs comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a16c787f8df9324fd9b397ddcf9b96d
https://pubmed.ncbi.nlm.nih.gov/36205074

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Pharmaco-fUS: Quantification of pharmacologically-induced dynamic changes in brain perfusion and connectivity by functional ultrasound imaging in awake mice

Autor: Sophie Pezet, Xavier Mousset, Zsolt Lenkei, Adrien Bertolo, Claire Rabut, Mickael Tanter, Bruno-Felix Osmanski, Jérémy Ferrier, Thomas Deffieux

Publikováno v: NeuroImage
NeuroImage, Elsevier, 2020, 222, pp.117231. ⟨10.1016/j.neuroimage.2020.117231⟩
NeuroImage, 2020, 222, pp.117231. ⟨10.1016/j.neuroimage.2020.117231⟩
NeuroImage, Vol 222, Iss, Pp 117231-(2020)

International audience; There is a critical need for reliable quantitative biomarkers to assess functional brain alterations in mouse models of neuropsychiatric diseases, but current imaging methods measuring drug effects through the neurovascular co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9419d4a7cddaa5a713006c003628a3
https://www.hal.inserm.fr/inserm-02971488

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