Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Phanstiel O th"'
Autor:
Phanstiel O th, Michael E. Sigman, Bénédicte Martin, Jean-Guy Delcros, Konate F, Richard A. Gardner, Huang M, Breitbeil F rd
Publikováno v:
Journal of Medicinal Chemistry. 47:6055-6069
Several N(1)-arylalkylpolyamines containing various aromatic ring systems were synthesized as their respective HCl salts. The N(1)-substituents evaluated ranged in size from N(1)-benzyl, N(1)-naphthalen-1-ylmethyl, N(1)-2-(naphthalen-1-yl)ethyl, N(1)
Publikováno v:
Journal of Medicinal Chemistry. 45:2056-2063
Several iron chelators containing alpha,beta-unsaturated hydroxamic acid motifs appended to a citric acid platform were synthesized. Mycobacterium paratuberculosis was then challenged to grow in the presence of a panel of siderophores (mycobactin J,
Autor:
Phanstiel O th, Richard A. Gardner, Jean-Guy Delcros, Carias H, Cannon L, John Biggerstaff, Konate F, Wang C
Publikováno v:
Journal of medicinal chemistry. 46(24)
Several N(1)-substituted polyamines containing various spacer units between nitrogen centers were synthesized as their respective HCl salts. The N(1)-substituents included benzyl, naphthalen-1-ylmethyl, anthracen-9-ylmethyl, and pyren-1-ylmethyl. The
Publikováno v:
Journal of medicinal chemistry. 46(13)
A series of nine N(1)-(9-anthracenylmethyl)tetraamines (e.g., Ant-4,4,4-tetraamine) were synthesized and evaluated for cytotoxicity in L1210, alpha-difluoromethylornithine (DFMO)-treated L1210, Chinese hamster ovary (CHO), and CHO-MG cell lines. Surp
Autor:
Phanstiel O th, Lu Wang
Publikováno v:
The Journal of organic chemistry. 65(5)
Methods developed with N-(benzoyloxy)amines and hydroxamic acids were used in the synthesis of N-(hydroxy)amide-containing pseudopeptides. Acylation of N-(benzoyloxy)phenethylamine with the acid chloride of N(alpha)-Fmoc-L-leucine provided a N(alpha)
Publikováno v:
The Journal of Organic Chemistry. 72:3158-3158
A modular synthesis was developed to access petrobactin, a catechol-containing siderophore isolated from Marinobacter hydrocarbonoclasticus. A range of petrobactin homologues with differing dihydroxybenzamide motifs and in one case an increased numbe