Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Phanankosi, Moyo"'
Autor:
Phanankosi Moyo, Michael Ofori, Olusola S. Bodede, Madelien Wooding, Ndivhuwo Kevin Khorommbi, Lyndy J. McGaw, Cynthia A. Danquah, Vinesh J. Maharaj
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The emergence of drug-resistant Mycobacterium tuberculosis strains is a threat to global health necessitating the discovery of novel chemotherapeutic agents. Natural products drug discovery, which previously led to the discovery of rifamycin
Externí odkaz:
https://doaj.org/article/bde2bd6ea9874e079e0bcf94e60c848a
Autor:
Phanankosi Moyo, Luke Invernizzi, Sephora M. Mianda, Wiehan Rudolph, Andrew W. Andayi, Mingxun Wang, Neil R. Crouch, Vinesh J. Maharaj
Publikováno v:
Natural Products and Bioprospecting, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract The emergence and spread of drug-recalcitrant Plasmodium falciparum parasites threaten to reverse the gains made in the fight against malaria. Urgent measures need to be taken to curb this impending challenge. The higher plant-derived sesqui
Externí odkaz:
https://doaj.org/article/aafcecec9a4c47c191e16778e16e60f1
Autor:
Phanankosi Moyo, Luke Invernizzi, Sephora M. Mianda, Wiehan Rudolph, Warren A. Andayi, Mingxun Wang, Neil R. Crouch, Vinesh J. Maharaj
Publikováno v:
Natural Products and Bioprospecting, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract The antimalarial drug-resistance conundrum which threatens to reverse the great strides taken to curb the malaria scourge warrants an urgent need to find novel chemical scaffolds to serve as templates for the development of new antimalarial
Externí odkaz:
https://doaj.org/article/019763d009274c179f8fac4d4c09cdfb
Autor:
Janette Reader, Mariëtte E. van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Sabine Ottilie, Anjo Theron, Phanankosi Moyo, Erica Erlank, Luisa Nardini, Nelius Venter, Sonja Lauterbach, Belinda Bezuidenhout, Andre Horatscheck, Ashleigh van Heerden, Natalie J. Spillman, Anne N. Cowell, Jessica Connacher, Daniel Opperman, Lindsey M. Orchard, Manuel Llinás, Eva S. Istvan, Daniel E. Goldberg, Grant A. Boyle, David Calvo, Dalu Mancama, Theresa L. Coetzer, Elizabeth A. Winzeler, James Duffy, Lizette L. Koekemoer, Gregory Basarab, Kelly Chibale, Lyn-Marié Birkholtz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Here, Reader et al. screen the Medicines for Malaria Venture Pandemic Response Box in parallel against Plasmodiumasexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. They identify two potent transmission-bl
Externí odkaz:
https://doaj.org/article/469ad5b32c23403795a07ad1d5fdbabe
Autor:
Phanankosi Moyo, William Shamburger, Mariëtte E. van der Watt, Janette Reader, Ana Carolina C. de Sousa, Timothy J. Egan, Vinesh J. Maharaj, Gerhard Bringmann, Lyn-Marie Birkholtz
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss , Pp 51-58 (2020)
The discovery and development of multistage antimalarial drugs targeting intra-erythrocytic asexual and sexual Plasmodium falciparum parasites is of utmost importance to achieve the ambitious goal of malaria elimination. Here, we report the validatio
Externí odkaz:
https://doaj.org/article/642b4370fc534b02bced97c3b270352b
Autor:
Phanankosi Moyo, Phaladi Kunyane, Mamoalosi A. Selepe, Jacobus N. Eloff, Jandeli Niemand, Abraham I. Louw, Vinesh J. Maharaj, Lyn-Marie Birkholtz
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019)
Abstract Background Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of different sources of drugs in search of transmission-blocking agents. W
Externí odkaz:
https://doaj.org/article/304eb84e92a24cfeb82cacf5cb45ff0e
Autor:
Cynthia Amaning Danquah, Prince Amankwah Baffour Minkah, Theresa A. Agana, Phanankosi Moyo, Michael Ofori, Peace Doe, Sibusiso Rali, Isaiah Osei Duah Junior, Kofi Bonsu Amankwah, Samuel Owusu Somuah, Isaac Newton Nugbemado, Vinesh J. Maharaj, Sanjib Bhakta, Simon Gibbons
Publikováno v:
Molecules, Vol 27, Iss 14, p 4475 (2022)
Amaryllidaceae is a significant source of bioactive phytochemicals with a strong propensity to develop new drugs. The genera Allium, Tulbaghia, Cyrtanthus and Crinum biosynthesize novel alkaloids and other phytochemicals with traditional and pharmaco
Externí odkaz:
https://doaj.org/article/58a9ea7254d54267a80782231a1a0b15
Autor:
Babalwa Tembeni, Amanda Sciorillo, Luke Invernizzi, Thomas Klimkait, Lorena Urda, Phanankosi Moyo, Dashnie Naidoo-Maharaj, Nathan Levitties, Kwasi Gyampoh, Guorui Zu, Zhe Yuan, Karam Mounzer, Siphathimandla Nkabinde, Magugu Nkabinde, Nceba Gqaleni, Ian Tietjen, Luis J. Montaner, Vinesh Maharaj
Publikováno v:
Viruses, Vol 14, Iss 7, p 1437 (2022)
Despite the success of combination antiretroviral therapy (cART), HIV persists in low- and middle-income countries (LMIC) due to emerging drug resistance and insufficient drug accessibility. Furthermore, cART does not target latently-infected CD4+ T
Externí odkaz:
https://doaj.org/article/ce4feee224674d27b2d1091e127ab9b1
Autor:
Anuradha Thakur, Phanankosi Moyo, Carl Johan van der Westhuizen, Hyun Ok Yang, Vinesh Maharaj
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 743 (2021)
Elevated levels of the amylo β-proteins (Aβ), particularly Aβ42, are associated with a high risk of Alzheimer’s disease (AD). The Aβ proteins are produced from cellular processing of the amyloid precursor proteins (APPs). To identify natural pr
Externí odkaz:
https://doaj.org/article/f85cc746d0894a529ff07003b32572d4
Autor:
Luke Invernizzi, Phanankosi Moyo, Joel Cassel, Freddie J. Isaacs, Joseph M. Salvino, Luis J. Montaner, Ian Tietjen, Vinesh Maharaj
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:3971-3985
SARS-CoV-2, the causative agent of COVID-19, continues to cause global morbidity and mortality despite the increasing availability of vaccines. Alongside vaccines, antivirals are urgently needed to combat SARS-CoV-2 infection and spread, particularly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3d28c70b6a9a96adb82473d2fb0bf0
https://doi.org/10.1007/s00216-022-04041-3
https://doi.org/10.1007/s00216-022-04041-3