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Autor:
Baldo, Brian A., Pham, Nghia H.
Publikováno v:
Drug Allergy
Proteins dominate the extensive and growing list of approved biotherapeutic agents used in medicine today. Proteins, as targeted antibodies, tiny concentrations of hormones and cytokines; many enzymes; fusion proteins and receptors; “factors” inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::e3c5b95d06cc4376bbf3c30168fed986
http://europepmc.org/articles/PMC7979095
http://europepmc.org/articles/PMC7979095
Autor:
Baldo, Brian A., Pham, Nghia H.
Publikováno v:
Drug Allergy
Specific targeting of tumor cells without inflicting collateral damage on normal healthy cells has been, and remains, a long-standing aim in cancer therapy. Effective targeting of tumor cells without accompanying toxicity has started to be realized w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::f696aa5cc9332ff5cfdfffdd94acbb51
http://europepmc.org/articles/PMC7979054
http://europepmc.org/articles/PMC7979054
Autor:
Baldo, Brian A., Pham, Nghia H.
Publikováno v:
Drug Allergy
In a 2017 analysis, 61 of 150 anticancer drugs approved by the FDA were classified as cytotoxic and 89 as targeted drugs. For many years, cytotoxic compounds have been the front line of cancer chemotherapy, but their action of destroying rapidly divi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::9880ac0f640f95108ae41d63f43a7f09
http://europepmc.org/articles/PMC7979052
http://europepmc.org/articles/PMC7979052
Autor:
Baldo, Brian A., Pham, Nghia H.
Publikováno v:
Archives of Toxicology; Feb2023, Vol. 97 Issue 2, p359-375, 17p
Autor:
Baldo, Brian A., Pham, Nghia H.
Publikováno v:
Drug Allergy
Currently, ~28–30 mAbs are approved or under consideration for approval as specific therapies in the USA or European Union, although about 350 new mAbs for therapeutic application in humans are in the commercial pipeline. So far, the number of targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::180eb166a8ca2043455c4c7ddff4fd04
http://europepmc.org/articles/PMC7121109
http://europepmc.org/articles/PMC7121109
Autor:
Baldo, Brian A., Pham, Nghia H.
Publikováno v:
Drug Allergy
Allergic reactions to drugs are not always the result of the drug’s protein-binding capacity, biotransformation, or degradation. Mediator release from mast cells may occur via cross-linking of cell-bound IgE by di-(multi)valent free drug. The FcεR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_dedup___::bb385a1514148cd9e15ccdbe2faee396
http://europepmc.org/articles/PMC7120502
http://europepmc.org/articles/PMC7120502
Autor:
Baldo, Brian A., Pham, Nghia H.
Publikováno v:
In The Journal of Allergy and Clinical Immunology November 2015 136(5):1426-1428