Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Phagocytic cup"'
Phagocytosis is the mechanism of the internalization of large particles, microorganisms and cellular debris. The complement pathway represents one of the first mechanisms of defense against infection and the complement receptor 3 (CR3), which is high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f09297882ae1b6b4aa75c161a7f24d3
https://hal.archives-ouvertes.fr/hal-03453678
https://hal.archives-ouvertes.fr/hal-03453678
Autor:
Sarah R. Barger, Nils C. Gauthier, Mira Krendel, Daan Vorselen, Julie A. Theriot, Wei Cai, Yifan Wang
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Phagocytosis requires rapid actin reorganization and spatially controlled force generation to ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs membrane extensions to engulf such diverse targets remains unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284bd5a88faf738d4303317dea9088ee
https://doi.org/10.7554/elife.68627
https://doi.org/10.7554/elife.68627
Autor:
Je-Yoel Cho, Seung Yoon Park, Jae Hoon Pyo, Soyoun Kim, In San Kim, Jae Do Yoo, Sang Yeob Kim, Dong Jun Bae, Junyoung Seo, Wonhwa Cho
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:1595-1607
The rapid and precise clearance of apoptotic cells (efferocytosis) involves a series of phagocytic processes through which apoptotic cells are recognized, engulfed, and degraded within phagocytes. The Rho-family GTPases critically rearrange the cytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0334c1ef52883a7095e290cc537abdbe
https://doi.org/10.1016/j.bbamcr.2019.07.003
https://doi.org/10.1016/j.bbamcr.2019.07.003
Publikováno v:
Nature cell biology
αMβ2 integrin (complement receptor 3) is a major receptor for phagocytosis in macrophages. In other contexts, integrins' activities and functions are mechanically linked to actin dynamics through focal adhesions. We asked whether mechanical couplin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01416f2ef28c1eef6a1233f6db67da9f
http://europepmc.org/articles/PMC6858589
http://europepmc.org/articles/PMC6858589
Publikováno v:
Biochemical and Biophysical Research Communications. 515:163-168
It has been proposed that Ca2+ activation of calpain-1 is important for the rapid cell shape changes which accompany phagocytosis. In this paper, we use a fluorogenic calpain substrate, (CBZ-Ala Ala)2 R110, and find that there was a low calpain activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bac187e978b1f22194251ceaec8c22f
https://doi.org/10.1016/j.bbrc.2019.05.125
https://doi.org/10.1016/j.bbrc.2019.05.125
Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
Autor:
John M. Heddleston, Qingsen Li, Nils C. Gauthier, Richard A. Flavell, Nicholas S. Reilly, Tatyana Svitkina, Mark S. Mooseker, Maria S. Shutova, Paolo Maiuri, Sarah R. Barger, Patrick W. Oakes, Mira Krendel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
Phagocytosis of invading pathogens or cellular debris requires a dramatic change in cell shape driven by actin polymerization. For antibody-covered targets, phagocytosis is thought to proceed through the sequential engagement of Fc-receptors on the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70848d58f28a53ca84dd4693743997d7
http://link.springer.com/article/10.1038/s41467-019-09104-1
http://link.springer.com/article/10.1038/s41467-019-09104-1
Autor:
Xuehua Xu, Keqiang Chen, Xi Wen, Tian Jin, Ji Ming Wang, Miao Pan, Silvia Bolland, Wenxiang Sun
Publikováno v:
Molecular Biology of the Cell
A dogma of innate immunity is that neutrophils use G-protein–coupled receptors (GPCRs) for chemoattractant to chase bacteria through chemotaxis and then use phagocytic receptors coupled with tyrosine kinases to destroy opsonized bacteria via phagoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ce65a5c37ba8f3c100d87408f28f90
https://doi.org/10.1091/mbc.e18-06-0358
https://doi.org/10.1091/mbc.e18-06-0358
Autor:
Hans C. Leier, Fabian Pott, Caroline Barisch, Patrick Niekamp, Fikadu G. Tafesse, Ali Rashidfarrokhi, Veronica Richina, Gaelen Guzman, Joost C. M. Holthuis
Publikováno v:
mBio
mBio, Vol 12, Iss 1 (2021)
mBio, Vol 12, Iss 1 (2021)
Mycobacterium tuberculosis (Mtb) invades alveolar macrophages through phagocytosis to establish infection and cause disease. The molecular mechanisms underlying Mtb entry are still poorly understood.
Phagocytosis by alveolar macrophages is the o
Phagocytosis by alveolar macrophages is the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27076bde441208e0f2b9674b50b92c49
https://pubmed.ncbi.nlm.nih.gov/33500344
https://pubmed.ncbi.nlm.nih.gov/33500344
Autor:
Markus Horsthemke, Peter J. Hanley, Anne C. Bachg, Stefan Walbaum, Attila Mócsai, Benjamin Ambrosy, Jeanette H. W. Leusen, Paula Schütz
Publikováno v:
The Journal of Biological Chemistry
A long-standing hypothesis is that complement receptors (CRs), especially CR3, mediate sinking phagocytosis, but evidence is lacking. Alternatively, CRs have been reported to induce membrane ruffles or phagocytic cups, akin to those induced by Fcγ r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c2805f13edd690106f43f49a860e61
http://europepmc.org/articles/PMC7948798
http://europepmc.org/articles/PMC7948798
Autor:
Wen-Biao Gan, Zongyue Cheng, Laetitia Weinhard, Alexia Tiberi, Ruohe Zhao, Alejandro Martin-Avila
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::430eec40083c0eb1374edf95b8f25f7e
https://doi.org/10.1002/alz.045504
https://doi.org/10.1002/alz.045504