Zobrazeno 1 - 10
of 997
pro vyhledávání: '"Phage display library"'
Autor:
Behnam Hasannejad-Asl, Hassan Hashemzadeh, Farkhondeh Pooresmaeil, Mehran Dabiri, Mohammad-Reza Pooresmaeil, Davoud Ahmadvand, Arshad Hosseini
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
IntroductionDuring the last decade, there has been a significant rise in the use of therapeutic antibodies or passive immunotherapy for treating various conditions like inflammation and cancer. However, these proteins face challenges reaching the bra
Externí odkaz:
https://doaj.org/article/5b8d13ba525b4be5842b0305ec777ae6
Autor:
Kexuan Cheng, Jiansheng Lu, Jiazheng Guo, Rong Wang, Lei Chen, Xi Wang, Yujia Jiang, Yating Li, Changyan Xu, Qinglin Kang, Gulisaina Qiaerxie, Peng Du, Chen Gao, Yunzhou Yu, Zhixin Yang, Wei Wang
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Tetanus toxin (TeNT) is one of the most toxic proteins. Neutralizing antibodies against TeNT are effective in prevention and treatment. In this study, 14 anti-tetanus nanobodies were obtained from a phage display nanobody library by immunizing a came
Externí odkaz:
https://doaj.org/article/13b0ffc440814458b9e5816a3a74d3a7
Autor:
Tiantian Zhang, Zhe Wang
Publikováno v:
Biologics, Vol 4, Iss 1, Pp 55-74 (2024)
Thirty-four years ago, the groundbreaking work of John McCafferty and Sir Gregory Winter in developing phage display technology revolutionized the discovery of human antibodies, paving the way for diverse applications. Since then, numerous phage-deri
Externí odkaz:
https://doaj.org/article/cf6f71978b234df6be88fd6dbd3a8483
Publikováno v:
International Journal of Nanomedicine, Vol Volume 18, Pp 7173-7181 (2023)
Ni Meng, Xiaolong Cheng, Mengyao Sun, Yushan Zhang, Xueke Sun, Xifu Liu, Jing Chen Ministry of Education Key Laboratory of Molecular and Cellular Biology; Hebei Anti-Tumor Molecular Target Technology Innovation Center; Hebei Research Center of the Ba
Externí odkaz:
https://doaj.org/article/4c1b377cd74d4c7297aacad0e905aeb7
Autor:
Yujia Jiang, Rong Wang, Jiazheng Guo, Kexuan Cheng, Lei Chen, Xi Wang, Yating Li, Peng Du, Chen Gao, Jiansheng Lu, Yunzhou Yu, Zhixin Yang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundBotulinum neurotoxin (BoNT) produced by Clostridium botulinum is one of the most potent known toxins. Moreover, BoNT is classified as one of the most important biological warfare agents that threatens the biosafety of the world. Currently,
Externí odkaz:
https://doaj.org/article/378a8cb9a0244879bdbfffd6cf77c7ed
Autor:
Jiali Wang, Bingjie Shi, Hanyi Chen, Mengyuan Yu, Peipei Wang, Zhaohui Qian, Keping Hu, Jianxun Wang
Publikováno v:
Vaccines, Vol 12, Iss 4, p 417 (2024)
Most available neutralizing antibodies are ineffective against highly mutated SARS-CoV-2 Omicron subvariants. Therefore, it is crucial to develop potent and broad-spectrum alternatives to effectively manage Omicron subvariants. Here, we constructed a
Externí odkaz:
https://doaj.org/article/e4f205e8d0e1449da93215a7512b2efb
Autor:
Tamaki Kobayashi, Kazuki Yamazaki, Junki Shinada, Masataka Mizunuma, Kazuhiro Furukawa, Yoshiro Chuman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3737 (2024)
Protein phosphorylation is a prevalent translational modification, and its dysregulation has been implicated in various diseases, including cancer. Despite its significance, there is a lack of specific inhibitors of the FCP/SCP-type Ser/Thr protein p
Externí odkaz:
https://doaj.org/article/2ab05c8edaea48779d4c17df033a130a
Autor:
Eilnaz Basardeh, Somayeh Piri-Gavgani, Behnoush Soltanmohammadi, Mostafa Ghanei, Mir Davood Omrani, Mahdieh Soezi, Mohammad Ali Shokrgozar, Maasoumeh Azizi, Abolfazl Fateh, Farzam Vaziri, Seyed Davar Siadat, Zahra Sharifzadeh, Fatemeh Rahimi-Jamnani
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 25, Iss 9, Pp 1141-1149 (2022)
Objective(s): The high resistance rate of Acinetobacter baumannii and the limited number of available antibiotics have prompted a worldwide effort to develop effective antimicrobial agents. Accordingly, identifying single-chain variable fragment anti
Externí odkaz:
https://doaj.org/article/27f8dc8fee6c405ea78a47e330900a14
Publikováno v:
Methods and Protocols, Vol 7, Iss 1, p 13 (2024)
The development of monoclonal antibodies (mAbs) represents a significant milestone in both basic research and clinical applications due to their target specificity and versatility in therapeutic and diagnostic applications. The innovative strategy of
Externí odkaz:
https://doaj.org/article/eb7a03e7366646809b6fb04fadc7880d
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