Zobrazeno 1 - 10
of 25 192
pro vyhledávání: '"Phage display"'
Autor:
Yu Fan, Ruibing Feng, Xinya Zhang, Zhen-Liang Wang, Feng Xiong, Shuihua Zhang, Zhang-Feng Zhong, Hua Yu, Qing-Wen Zhang, Zhang Zhang, Yitao Wang, Guodong Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3362-3384 (2024)
Drug discovery is a sophisticated process that incorporates scientific innovations and cutting-edge technologies. Compared to traditional bioactivity-based screening methods, encoding and display technologies for combinatorial libraries have recently
Externí odkaz:
https://doaj.org/article/8c51e2672b6e4c08aee0596430c903da
Autor:
Johanna Kliche, Leandro Simonetti, Izabella Krystkowiak, Hanna Kuss, Marcel Diallo, Emma Rask, Jakob Nilsson, Norman E Davey, Ylva Ivarsson
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 9, Pp 1025-1048 (2024)
Abstract Whole genome and exome sequencing are reporting on hundreds of thousands of missense mutations. Taking a pan-disease approach, we explored how mutations in intrinsically disordered regions (IDRs) break or generate protein interactions mediat
Externí odkaz:
https://doaj.org/article/0bbc2585d8e5430193b425c67f6f3b23
Autor:
Yulia S. Massino, Yulia N. Tarakanova, Olga L. Segal, Anastasia A. Pechelyulko, Dinora A. Yakovleva, Maria V. Lichutina, Dmitriy A. Dmitriev, Alexander D. Dmitriev
Publikováno v:
Журнал микробиологии, эпидемиологии и иммунобиологии, Vol 101, Iss 3, Pp 412-427 (2024)
Monoclonal antibodies are widely used in all fields of biology and medicine. The emergence and development of the technology for their production revolutionized immunology and allowed the creation of not only new diagnostic methods, but also many eff
Externí odkaz:
https://doaj.org/article/17dd52db90804d1e8d601fdc1ddbf7d5
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Using conventional immunoglobulin G (IgG) molecules as therapeutic agents presents several well-known disadvantages owing to their large size and structural complexity, negatively impacting development and production efficiency. Single-domai
Externí odkaz:
https://doaj.org/article/d86067ade20f4a04a6a1aa6bb6b3d357
Autor:
Tao Wang, Peng Tan, Qi Tang, Chenlong Zhou, Yakun Ding, Shenrui Xu, Mengda Song, Huiyang Fu, Yucheng Zhang, Xiaohui Zhang, Yueyu Bai, Zhihong Sun, Xi Ma
Publikováno v:
mLife, Vol 3, Iss 2, Pp 251-268 (2024)
Abstract Broad‐spectrum antibacterial drugs often lack specificity, leading to indiscriminate bactericidal activity, which can disrupt the normal microbial balance of the host flora and cause unnecessary cytotoxicity during systemic administration.
Externí odkaz:
https://doaj.org/article/7c1f3821d2b64b15a9eb7374c784af46
Autor:
Jinsha Liu, John Heddleston, Douglas Raymond Perkins, Jack Jia Hua Chen, Ahmadreza Ghanbarpour, Bill William Smith, Rebecca Miles, Eitaro Aihara, Sepideh Afshar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The primary hurdles for small interference RNA (siRNA) in clinical use are targeted and cytosolic delivery. To overcome both challenges, we have established a novel platform based on phage display, called NNJA. In this approach, a lysosomal
Externí odkaz:
https://doaj.org/article/6e30468b1d324604beec000ab63fc69b
Publikováno v:
Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, Vol 24, Iss 2, Pp 202-207 (2024)
Large-scale production and use of antimicrobials in human, veterinary and agricultural applications has led to antibiotic contamination of water resources. Therefore, it is relevant to develop methods for monitoring the content of antibiotics, especi
Externí odkaz:
https://doaj.org/article/b497f8dde1834cd4b2e7d49b45e3edc7
Autor:
Narangerel Ganbaatar, Ting-Chieh Chu, Naofumi Okamoto, Kenji Iwahori, Masakazu Nakamura, Ichiro Yamashita
Publikováno v:
Biophysica, Vol 4, Iss 2, Pp 256-266 (2024)
The adsorption behavior of recombinant cage-shaped proteins with carbon nanotube (CNT)-binding peptides on carbon surfaces was quantitatively and dynamically analyzed using a highly stable quartz crystal microbalance (QCM). Two types of CNT-binding p
Externí odkaz:
https://doaj.org/article/49303867f6bc43b9a73d6db7d31267ff
Autor:
Li Zhang, Binyang Zheng, Jing Lu, Haisheng Wu, Hailian Wu, Qi Zhang, Lei Jiao, Hongxing Pan, Jianfang Zhou
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 10 (2024)
ABSTRACT Yersinia pestis has a broad host range and has caused lethal bubonic and pneumonic plague in humans. With the emergence of multiple resistant strains and the potential for biothreat use, there is an urgent need for new therapeutic strategies
Externí odkaz:
https://doaj.org/article/405978c24c274707bcd77e7bc49a20aa
Autor:
Jifu Ma, Bakhet Bodai, Zhongmei Ma, Kezerbek Khalembek, Jingang Xie, Rizabek Kadyken, Mukhtar Baibatshanov, Oralhazi Kazkhan
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36180- (2024)
Background: Inhibin is a member of the transforming growth factor family that influences reproduction in animals. Objective: The purpose of this study was to obtain nanobodies from the phage antibody library constructed by us that can specifically bi
Externí odkaz:
https://doaj.org/article/f04798eea85f4610b6ad0e0d5091ca49