Zobrazeno 1 - 10
of 25 209
pro vyhledávání: '"Phage Display"'
Autor:
Soobin Han, Ji Hong Kim, Vivek Kumar Gupta, Ju Eun Bae, Chae Hwan Cho, Hanseung Kim, Yonghyeon Park, Mi‐Hwa Oh, Jong Pil Park Professor, Yun Suk Huh
Publikováno v:
Food Frontiers, Vol 5, Iss 6, Pp 2591-2604 (2024)
Abstract The globalization of food distribution has made it necessary to ensure the delivery of fresh food to the consumers. Protein‐rich foods produce a significant amount of tyramine when spoiled. Therefore, it was envisaged to develop localized
Externí odkaz:
https://doaj.org/article/7facf9a096ae4f22b7d4db500d4d6d3e
Autor:
Sharareh Mohammad Hasani, Mahdi Behdani, Zohreh Amirkhani, Ilnaz Rahimmanesh, Mahsa Esmaeilifallah, Erfan Zaker, Parvaneh Nikpour, Mahmood Fadaie, Elham Ghafouri, Shamsi Naderi, Hossein Khanahmad
Publikováno v:
Research in Pharmaceutical Sciences, Vol 19, Iss 5, Pp 573-590 (2024)
Background and purpose: The global emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has prompted widespread concern. Bacteriophages have recently gained attention as a cost-effective and stable alternative for vaccine dev
Externí odkaz:
https://doaj.org/article/7412bf70a95946cbbe1e94c4e75346be
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Influenza continues to be one of the top public health problems since it creates annual epidemics and can start a worldwide pandemic. The virus’s rapid evolution allows the virus to evade the host defense, and then seasonal vaccines need t
Externí odkaz:
https://doaj.org/article/e5ef4b3df0214805bf501989900c1135
Autor:
Yu Fan, Ruibing Feng, Xinya Zhang, Zhen-Liang Wang, Feng Xiong, Shuihua Zhang, Zhang-Feng Zhong, Hua Yu, Qing-Wen Zhang, Zhang Zhang, Yitao Wang, Guodong Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3362-3384 (2024)
Drug discovery is a sophisticated process that incorporates scientific innovations and cutting-edge technologies. Compared to traditional bioactivity-based screening methods, encoding and display technologies for combinatorial libraries have recently
Externí odkaz:
https://doaj.org/article/8c51e2672b6e4c08aee0596430c903da
Autor:
Johanna Kliche, Leandro Simonetti, Izabella Krystkowiak, Hanna Kuss, Marcel Diallo, Emma Rask, Jakob Nilsson, Norman E Davey, Ylva Ivarsson
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 9, Pp 1025-1048 (2024)
Abstract Whole genome and exome sequencing are reporting on hundreds of thousands of missense mutations. Taking a pan-disease approach, we explored how mutations in intrinsically disordered regions (IDRs) break or generate protein interactions mediat
Externí odkaz:
https://doaj.org/article/0bbc2585d8e5430193b425c67f6f3b23
Autor:
Yulia S. Massino, Yulia N. Tarakanova, Olga L. Segal, Anastasia A. Pechelyulko, Dinora A. Yakovleva, Maria V. Lichutina, Dmitriy A. Dmitriev, Alexander D. Dmitriev
Publikováno v:
Журнал микробиологии, эпидемиологии и иммунобиологии, Vol 101, Iss 3, Pp 412-427 (2024)
Monoclonal antibodies are widely used in all fields of biology and medicine. The emergence and development of the technology for their production revolutionized immunology and allowed the creation of not only new diagnostic methods, but also many eff
Externí odkaz:
https://doaj.org/article/17dd52db90804d1e8d601fdc1ddbf7d5
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Using conventional immunoglobulin G (IgG) molecules as therapeutic agents presents several well-known disadvantages owing to their large size and structural complexity, negatively impacting development and production efficiency. Single-domai
Externí odkaz:
https://doaj.org/article/d86067ade20f4a04a6a1aa6bb6b3d357
Autor:
Tao Wang, Peng Tan, Qi Tang, Chenlong Zhou, Yakun Ding, Shenrui Xu, Mengda Song, Huiyang Fu, Yucheng Zhang, Xiaohui Zhang, Yueyu Bai, Zhihong Sun, Xi Ma
Publikováno v:
mLife, Vol 3, Iss 2, Pp 251-268 (2024)
Abstract Broad‐spectrum antibacterial drugs often lack specificity, leading to indiscriminate bactericidal activity, which can disrupt the normal microbial balance of the host flora and cause unnecessary cytotoxicity during systemic administration.
Externí odkaz:
https://doaj.org/article/7c1f3821d2b64b15a9eb7374c784af46
Autor:
Jinsha Liu, John Heddleston, Douglas Raymond Perkins, Jack Jia Hua Chen, Ahmadreza Ghanbarpour, Bill William Smith, Rebecca Miles, Eitaro Aihara, Sepideh Afshar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The primary hurdles for small interference RNA (siRNA) in clinical use are targeted and cytosolic delivery. To overcome both challenges, we have established a novel platform based on phage display, called NNJA. In this approach, a lysosomal
Externí odkaz:
https://doaj.org/article/6e30468b1d324604beec000ab63fc69b
Autor:
Li Zhang, Binyang Zheng, Jing Lu, Haisheng Wu, Hailian Wu, Qi Zhang, Lei Jiao, Hongxing Pan, Jianfang Zhou
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 10 (2024)
ABSTRACT Yersinia pestis has a broad host range and has caused lethal bubonic and pneumonic plague in humans. With the emergence of multiple resistant strains and the potential for biothreat use, there is an urgent need for new therapeutic strategies
Externí odkaz:
https://doaj.org/article/405978c24c274707bcd77e7bc49a20aa