Effects of the bacterial status of rats on the changes in some liver cytochrome P450 (EC1.14.14.1) apoproteins consequent to a glucosinolate-rich diet

Autor: Lionelle Nugon-Baudon, Jean-Pierre Flinois, Ph. Beaune, Sylvie Rabot, Stephen Lory

Publikováno v: British Journal of Nutrition. 80:231-234

The aim of the present work was to investigate the influence of the intestinal microflora on the changes in hepatic cytochrome P450 apoproteins induced by dietary glucosinolates. Ten rats harbouring a conventional digestive microflora were offered ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7469e2b9dce806db0a32b2094d23824
https://doi.org/10.1017/s0007114598001275

Contribution of human cytochrome P450 to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol metabolism, as predicted from heterologous expression in yeast

Autor: Philippe Urban, Denis Pompon, Ph. Beaune, Jean-Charles Gautier, Cosme J, Sylvaine Lecoeur, Alain Perret

Publikováno v: Pharmacogenetics. 6:489-499

The metabolism of benzo[a]pyrene (B[a]P) and its proximate mutagen B[a]P-7,8-dihydrodiol (7,8-diol) was investigated in the presence of human microsomal epoxide hydrolase and P450 1A1, 1A2, 2C8, 2C9, 2C18, 2C19, 2D6 and 3A4 expressed in the yeast Sac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b134f0fcb374c4773d3eb284975ab5e9
https://doi.org/10.1097/00008571-199612000-00002

Recombinant yeast in drug metabolism

Autor: Gilles Truan, Christophe Cullin, Philippe Urban, Marie-Anne Peyronneau, Ph. Beaune, Daniel Mansuy, Jean-Paul Renaud, Denis Pompon

Publikováno v: Toxicology. 82:39-52

The usefulness of cDNA-directed expression of human hepatic P450s in yeast for the in vitro study of drug metabolism is emphasized. The major advantages of yeast expression are: (i) relatively high yields of heterologous P450 (approximately 5-10 nmol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ff978d8dc1c64c7bfcad453cb03f06
https://doi.org/10.1016/0300-483x(93)90058-z

A Guideline to Organize Communication Infrastructure for Alliances of SME

Autor: Frédérique Biennier, E Marcon, Ph. Beaune

Publikováno v: IFIP Advances in Information and Communication Technology ISBN: 9781475747898
PRO-VE
Collaborative Business Ecosystems and Virtual Enterprises
Luis M. Camarinha-Matos. Collaborative Business Ecosystems and Virtual Enterprises, Springer US, pp 303-310, 2002, IFIP--The International Federation for Information Processing Volume 85, 978-1-4757-4789-8. ⟨10.1007/978-0-387-35585-6_33⟩

International audience; Information and communication technologies can be seen as driving elements in virtual enterprise organization. As far as alliances of SMEs are concerned, the required infrastructure must be light, with a rather low cost. To ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8aaaa9a653ede69da22a0259b450bb
https://doi.org/10.1007/978-0-387-35585-6_33

Drug-induced immunotoxicity

Autor: Dominique Pessayre, Daniel Mansuy, Claire Minoletti, Ph. Beaune, E. Bonierbale, Patrick M. Dansette

Publikováno v: ResearcherID

Immune-related drug responses are one of the most common sources of idiosyncratic toxicity. A number of organs may be the target of such reactions; however, this review concentrates mostly on the liver. Drug-induced hepatitis is generally divided int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca5e04fb8e38c6867c11bf0e5ca57a0
https://pubmed.ncbi.nlm.nih.gov/10323325