Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Ph, Maxwell"'
Publikováno v:
Europe PubMed Central
Many adaptive responses to hypoxia involve changes in gene transcription mediated by the hypoxia-inducible factor 1 complex. Central to this is oxygen-dependent proteolysis of the alpha subunit, which has recently been shown to require the von Hippel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1aab94b002590ef0aa064db77892b311
https://pubmed.ncbi.nlm.nih.gov/11423722
https://pubmed.ncbi.nlm.nih.gov/11423722
Autor:
Cw, Pugh, Gw, Chang, Cockman M, Ac, Epstein, Jm, Gleadle, Ph, Maxwell, Lg, Nicholls, Rourke Jf, O., Peter Ratcliffe, Ec, Raybould, Ym, Tian, Ms, Wiesener, Wood M, Cc, Wykoff, Km, Yeates
Publikováno v:
Europe PubMed Central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e283ccc176f3a7edbec88c9263f188c5
https://pubmed.ncbi.nlm.nih.gov/10561745
https://pubmed.ncbi.nlm.nih.gov/10561745
Autor:
Ms, Wiesener, Turley H, We, Allen, Willam C, Ku, Eckardt, Kl, Talks, Sm, Wood, Kc, Gatter, Al, Harris, Cw, Pugh, Peter Ratcliffe, Ph, Maxwell
Publikováno v:
Europe PubMed Central
Hypoxia results in adaptive changes in the transcription of a range of genes including erythropoietin. An important mediator is hypoxia-inducible factor-1 (HIF-1), a DNA binding complex shown to contain at least two basic helix-loop-helix PAS-domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7eecf9de16704287ec59f734b84d0c2f
https://pubmed.ncbi.nlm.nih.gov/9746763
https://pubmed.ncbi.nlm.nih.gov/9746763
Autor:
Rourke Jf, O., Gu, Dachs, Jm, Gleadle, Ph, Maxwell, Chris Pugh, Ij, Stratford, Sm, Wood, Pj, Ratcliffe
Publikováno v:
Europe PubMed Central
Hypoxia-inducible factor-1 (HIF-1) has been shown to mediate the transcriptional activation of its target genes in response to oxygen concentration, most likely via a pathway involving a specific oxygen sensor. Molecular cloning of HIF-1 has shown th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::90222365c104fcfa5a3694919763f5dc
https://pubmed.ncbi.nlm.nih.gov/9406238
https://pubmed.ncbi.nlm.nih.gov/9406238
Autor:
Kj, Turner, Jw, Moore, Jones A, Cf, Taylor, Cuthbert-Heavens D, Han C, Russell Leek, Kc, Gatter, Ph, Maxwell, Pj, Ratcliffe, Cranston D, Al, Harris
Publikováno v:
Europe PubMed Central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::144e279171cbb48e9f78377a029fef4a
http://europepmc.org/abstract/med/12019178
http://europepmc.org/abstract/med/12019178
Publikováno v:
Europe PubMed Central
Regulation of the growth and metabolism of large organisms is tightly constrained by the need for precise oxygen homeostasis. Work on control of the haematopoietic growth factor erythropoietin has led to the recognition of a widespread transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::13c2ce11059e515cee82e4b562e0cccb
http://europepmc.org/abstract/med/11727931
http://europepmc.org/abstract/med/11727931
Publikováno v:
Europe PubMed Central
Matching oxygen consumption and supply represents a fundamental challenge to multicellular organisms. HIF-1 is a transcription complex which is emerging as a key mediator of oxygen homeostasis. HIF-1 controls the expression of many genes, including e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7edc84bed3b8aa1ecc06c02880a96849
http://europepmc.org/abstract/med/11950150
http://europepmc.org/abstract/med/11950150
Autor:
Cc, Wykoff, Nj, Beasley, Ph, Watson, Kj, Turner, Pastorek J, Sibtain A, Gd, Wilson, Turley H, Kl, Talks, Ph, Maxwell, Chris Pugh, Pj, Ratcliffe, Al, Harris
Publikováno v:
Europe PubMed Central
The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important mediator of gene expression patterns in tumors, although the range of responding genes is still incompletely defined. Here we show that the tumor-associated ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f532210015f93dfc690da08dcfda9884
http://europepmc.org/abstract/med/11156414
http://europepmc.org/abstract/med/11156414
Autor:
Ph, Maxwell, Dj, Ferguson, Mk, Osmond, Cw, Pugh, Heryet A, Bg, Doe, Mh, Johnson, Peter Ratcliffe
Publikováno v:
Europe PubMed Central
We have obtained transgenic mice in which an erythropoietin-SV40 virus T antigen fusion gene is homologously recombined into the native Epo locus. This gene is expressed in a tissue-specific manner closely resembling that of the native Epo gene. Immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5f6445be0acb786e1161132cd93225
http://europepmc.org/abstract/med/8080987
http://europepmc.org/abstract/med/8080987
Autor:
Chris Pugh, Gw, Chang, Cockman M, Ac, Epstein, Jm, Gleadle, Ph, Maxwell, Lg, Nicholls, Rourke Jf, O., Pj, Ratcliffe, Ec, Raybould, Ym, Tian, Ms, Wiesener, Wood M, Km, Yeates
Publikováno v:
Europe PubMed Central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c99b53cfa730c14fa4cbcbdf031ce405
http://europepmc.org/abstract/med/10561745
http://europepmc.org/abstract/med/10561745