Alanine mutation of the targeting subunit of the myosin phosphatase, MYPT1 at threonine 696 reduces cGMP responsiveness of mouse femoral arteries.

Autor: Lubomirov LT; Institute of Physiology, Brandenburg Medical School Theodor Fontane, Germany; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Germany; Vascular Biology Research Group (RenEVA), Research Institute, Medical University-Varna, Varna, Bulgaria; Institute of Physiology and Pathophysiology, Faculty of Health - School of Medicine, Biomedical Center for Education and Research (ZBAF), Witten/Herdecke University, Witten, Germany; Research Cluster, Molecular Mechanisms of Cardiovascular Diseases, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany. Electronic address: lubomir.lubomirov@mhb-fontane.de., Weber G; Institute of Physiology, Brandenburg Medical School Theodor Fontane, Germany., Schroeter M; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Germany., Metzler D; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Germany., Bust M; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Germany., Korotkova T; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Germany., Hescheler J; Institute of Neurophysiology, Center of Physiology, University of Cologne, Germany., Todorov VT; Institute of Physiology and Pathophysiology, Faculty of Health - School of Medicine, Biomedical Center for Education and Research (ZBAF), Witten/Herdecke University, Witten, Germany; Experimental Nephrology and Division of Nephrology, Department of Internal Medicine III, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany., Pfitzer G; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Germany., Grisk O; Institute of Physiology, Brandenburg Medical School Theodor Fontane, Germany; Research Cluster, Molecular Mechanisms of Cardiovascular Diseases, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2025 Jan 05; Vol. 986, pp. 177133. Date of Electronic Publication: 2024 Nov 17.

Senescent murine femoral arteries undergo vascular remodelling associated with accelerated stress-induced contractility and reactivity to nitric oxide.

Autor: Lubomirov LT; Institute of Physiology, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Cologne, Germany.; Research Cluster, Molecular Mechanisms of Cardiovascular Diseases, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany., Jänsch MH; Research Cluster, Molecular Mechanisms of Cardiovascular Diseases, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.; Department of Cardiology, Nephrology and Pneumology, Brandenburg Medical School, University Hospital Brandenburg, Brandenburg an der Havel, Germany., Papadopoulos S; Institute of Neurophysiology, Center of Physiology, University of Cologne, Cologne, Germany., Schroeter MM; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Cologne, Germany., Metzler D; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Cologne, Germany., Bust M; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Cologne, Germany., Hescheler J; Institute of Neurophysiology, Center of Physiology, University of Cologne, Cologne, Germany., Grisk O; Institute of Physiology, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.; Research Cluster, Molecular Mechanisms of Cardiovascular Diseases, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany., Ritter O; Research Cluster, Molecular Mechanisms of Cardiovascular Diseases, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.; Department of Cardiology, Nephrology and Pneumology, Brandenburg Medical School, University Hospital Brandenburg, Brandenburg an der Havel, Germany., Pfitzer G; Institute of Vegetative Physiology, Center of Physiology, University of Cologne, Cologne, Germany.

Publikováno v: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2022 Jan; Vol. 130 (1), pp. 70-83. Date of Electronic Publication: 2021 Nov 11.

New insights into the mechanisms of anandamide-induced airway dilation placing its degradation enzyme, FAAH center stage. Commentary on: Simon A, von Einem T, Seidinger A, Matthey M, Bindila L, Wenzel D (2022) The endocannabinoid anandamide is an airway relaxant in health and disease. Nat Commun 13:6941.

Autor: Pfitzer G; Institute of Vegetative Physiology, Medical Faculty, University of Cologne, Robert-Koch-Str. 39, 50931, Cologne, Germany. gabriele.pfitzer@uni-koeln.de.

Publikováno v: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2023 May; Vol. 475 (5), pp. 557-559. Date of Electronic Publication: 2023 Mar 01.

Involvement of small GTPases in the regulation of smooth muscle contraction.

Autor: PFITZER, G.¹ (AUTHOR), ARNER, A.² (AUTHOR)

Publikováno v: Acta Physiologica Scandinavica. Dec98, Vol. 164 Issue 4, p449-456. 8p. 1 Diagram, 3 Graphs.

Angiotensin II type 1 receptor localizes at the blood-bile barrier in humans and pigs.

Autor: Pryymachuk G; Department of Anatomy I, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany. galyna.pryymachuk@uk-koeln.de., El-Awaad E; Institute II of Pharmacology, Center of Pharmacology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Gleueler Str. 24, 50931, Cologne, Germany.; Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt., Piekarek N; Department of Anatomy I, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Drebber U; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Maul AC; Experimental Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Ostmerheimer Str. 200, 51109, Cologne, Germany., Hescheler J; Institute for Neurophysiology, Center for Physiology and Pathophysiology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch-Str. 39, 50931, Cologne, Germany., Wodarz A; Department of Anatomy I, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Cologne Excellence Cluster Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Robert-Koch-Str. 21, 50931, Cologne, Germany., Pfitzer G; Institute of Vegetative Physiology, Center for Physiology and Pathophysiology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch-Str. 39, 50931, Cologne, Germany., Neiss WF; Department of Anatomy I, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Pietsch M; Institute II of Pharmacology, Center of Pharmacology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Gleueler Str. 24, 50931, Cologne, Germany., Schroeter MM; Institute for Neurophysiology, Center for Physiology and Pathophysiology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch-Str. 39, 50931, Cologne, Germany.

Publikováno v: Histochemistry and cell biology [Histochem Cell Biol] 2022 May; Vol. 157 (5), pp. 513-524. Date of Electronic Publication: 2022 Feb 28.