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CRISPR-Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells

Autor: Lin-Shiao, Enrique, Pfeifer, Wolfgang G, Shy, Brian R, Saffari Doost, Mohammad, Chen, Evelyn, Vykunta, Vivasvan S, Hamilton, Jennifer R, Stahl, Elizabeth C, Lopez, Diana M, Sandoval Espinoza, Cindy R, Deyanov, Alexander E, Lew, Rachel J, Poirer, Michael G, Marson, Alexander, Castro, Carlos E, Doudna, Jennifer A

Publikováno v: Nucleic acids research, vol 50, iss 3

DNA nanostructures are a promising tool to deliver molecular payloads to cells. DNA origami structures, where long single-stranded DNA is folded into a compact nanostructure, present an attractive approach to package genes; however, effective deliver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::a0ad3f2f75cfc3a1dd7282076d44e51f
https://escholarship.org/uc/item/87j6t6zg

CRISPR-Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells.

Autor: Lin-Shiao E; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Pfeifer WG; Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, USA.; Department of Physics, The Ohio State University, Columbus, OH 43210, USA., Shy BR; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Saffari Doost M; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Chen E; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Vykunta VS; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA., Hamilton JR; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Stahl EC; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Lopez DM; Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, USA.; Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA.; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA., Sandoval Espinoza CR; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Deyanov AE; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Lew RJ; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA., Poirer MG; Department of Physics, The Ohio State University, Columbus, OH 43210, USA.; Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA.; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA., Marson A; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA., Castro CE; Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, USA.; Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley 94720, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA 94720, USA.; Gladstone Institutes, University of California, San Francisco, San Francisco, CA, 94158, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2022 Feb 22; Vol. 50 (3), pp. 1256-1268.