Inefficient tissue immune response against MPXV in an immunocompromised mpox patient.

Autor: Matschke J; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hartmann K; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Core Facility for (Mouse) Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pfefferle S; Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wang Y; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Valdes PA; Departments of Neurosurgery and Neurobiology, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Electrical and Computer Engineering, Rice University, Houston, Texas, USA., Thies E; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schweizer M; Morphology and Electron Microscopy Core Facility, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lütgehetmann M; Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schmiedel S; Division of Infectious Diseases, I. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bernreuther C; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Boyden ES; MIT, Cambridge, Massachusetts, USA.; Howard Hughes Medical Center, Cambridge, Massachusetts, USA., Glatzel M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Krasemann S; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Core Facility for (Mouse) Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Publikováno v: Journal of medical virology [J Med Virol] 2024 Jul; Vol. 96 (7), pp. e29811.

Analytical and clinical validation of a novel, laboratory-developed, modular multiplex-PCR panel for fully automated high-throughput detection of 16 respiratory viruses.

Autor: Tang HT; University Medical Center Hamburg-Eppendorf, Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany., Nörz D; University Medical Center Hamburg-Eppendorf, Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany., Grunwald M; University Medical Center Hamburg-Eppendorf, Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany., Giersch K; University Medical Center Hamburg-Eppendorf, Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany., Pfefferle S; University Medical Center Hamburg-Eppendorf, Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany., Fischer N; University Medical Center Hamburg-Eppendorf, Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany., Aepfelbacher M; University Medical Center Hamburg-Eppendorf, Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany., Rohde H; University Medical Center Hamburg-Eppendorf, Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany., Lütgehetmann M; University Medical Center Hamburg-Eppendorf, Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany. Electronic address: mluetgeh@uke.de.

Publikováno v: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2024 Aug; Vol. 173, pp. 105693. Date of Electronic Publication: 2024 May 16.

Analytical and clinical validation of a multiplex PCR assay for detection of Neisseria gonorrhoeae and Chlamydia trachomatis including simultaneous LGV serotyping on an automated high-throughput PCR system.

Autor: Pflüger LS; Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Nörz D; Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Grunwald M; Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Pfefferle S; Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Giersch K; Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Christner M; Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Weber B; Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Aepfelbacher M; Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Rohde H; Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, Hamburg, Germany., Lütgehetmann M; Center for Diagnostics, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, Hamburg, Germany.

Publikováno v: Microbiology spectrum [Microbiol Spectr] 2024 Mar 05; Vol. 12 (3), pp. e0275623. Date of Electronic Publication: 2024 Feb 12.

Molecular consequences of SARS-CoV-2 liver tropism.

Autor: Wanner N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Badia-I-Mompel P; Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, BioQuant, Heidelberg, Germany., Edler C; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pfefferle S; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lindenmeyer MT; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schmidt-Lauber C; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Czogalla J; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wong MN; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Okabayashi Y; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Braun F; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lütgehetmann M; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Meister E; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lu S; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Noriega MLM; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Günther T; Leibniz Institute for Experimental Virology, Hamburg, Germany., Grundhoff A; Leibniz Institute for Experimental Virology, Hamburg, Germany., Fischer N; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bräuninger H; Department of Cardiology, University Heart and Vascular Centre Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany., Lindner D; Department of Cardiology, University Heart and Vascular Centre Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany., Westermann D; Department of Cardiology, University Heart and Vascular Centre Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany., Haas F; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Roedl K; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kluge S; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Addo MM; I. Department of Medicine, University Medical Hospital Hamburg-Eppendorf, Hamburg, Germany.; German Center for Infection Research, Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Huber S; I. Department of Medicine, University Medical Hospital Hamburg-Eppendorf, Hamburg, Germany., Lohse AW; I. Department of Medicine, University Medical Hospital Hamburg-Eppendorf, Hamburg, Germany., Reiser J; Department of Medicine, Rush University Medical Center, Chicago, IL, USA., Ondruschka B; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sperhake JP; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Saez-Rodriguez J; Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, BioQuant, Heidelberg, Germany., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium and German Cancer Research Center, Partner Site Freiburg, Freiburg, Germany., Hayek SS; Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Aepfelbacher M; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Scaturro P; Leibniz Institute for Experimental Virology, Hamburg, Germany., Puelles VG; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. v.puelles@uke.de., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. t.huber@uke.de.

Publikováno v: Nature metabolism [Nat Metab] 2022 Mar; Vol. 4 (3), pp. 310-319. Date of Electronic Publication: 2022 Mar 28.

Evaluation of a Quantitative Dual-Target EBV DNA Test on a Fully Automated Molecular Testing System.

Autor: Lütgehetmann M; University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Albert E; Hospital Clínico Universitario, Fundación INCLIVA, School of Medicine, Valencia, Spain., Hamilton A; Roche Molecular Systems, Pleasanton, California, USA., Jarem D; Roche Molecular Systems, Pleasanton, California, USA., Pfefferle S; University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Stucki H; Roche Diagnostics International, Rotkreuz, Switzerland., Navarro D; Hospital Clínico Universitario, Fundación INCLIVA, School of Medicine, Valencia, Spain.

Publikováno v: Journal of clinical microbiology [J Clin Microbiol] 2023 Aug 23; Vol. 61 (8), pp. e0051823. Date of Electronic Publication: 2023 Jul 11.