¹⁹ F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase.

Autor: Nguyen A; Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 8, Marburg D-35032, Germany., Gemmecker G; Biomolecular NMR, Bavarian NMR Center, Technical University of Munich, Lichtenbergstraße 4, Garching D-85747, Germany.; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, Neuherberg 85764, Germany., Softley CA; Biomolecular NMR, Bavarian NMR Center, Technical University of Munich, Lichtenbergstraße 4, Garching D-85747, Germany.; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, Neuherberg 85764, Germany., Movsisyan LD; Laboratory of Organic Chemistry, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, Zürich CH-8093, Switzerland., Pfaffeneder T; Laboratory of Organic Chemistry, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, Zürich CH-8093, Switzerland., Heine A; Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 8, Marburg D-35032, Germany., Reuter K; Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 8, Marburg D-35032, Germany., Diederich F; Laboratory of Organic Chemistry, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, Zürich CH-8093, Switzerland., Sattler M; Biomolecular NMR, Bavarian NMR Center, Technical University of Munich, Lichtenbergstraße 4, Garching D-85747, Germany.; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, Neuherberg 85764, Germany., Klebe G; Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 8, Marburg D-35032, Germany.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2022 Jul 15; Vol. 17 (7), pp. 1745-1755. Date of Electronic Publication: 2022 Jun 28.

Enhanced thermal stability enables human mismatch-specific thymine–DNA glycosylase to catalyse futile DNA repair.

Autor: Manapkyzy, Diana^1,2 (AUTHOR), Joldybayeva, Botagoz^1,2 (AUTHOR), Ishchenko, Alexander A.³ (AUTHOR), Matkarimov, Bakhyt T.⁴ (AUTHOR), Zharkov, Dmitry O.^5,6 (AUTHOR), Taipakova, Sabira^1,2,4 (AUTHOR) sabira.taipakova@gmail.com, Saparbaev, Murat K.³ (AUTHOR) murat.saparbaev@gustaveroussy.fr

Publikováno v: PLoS ONE. 10/18/2024, Vol. 19 Issue 10, p1-32. 32p.

Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives

Autor: Spruijt, C.G., Gnerlich, F., Smits, A.H., Pfaffeneder, T., Jansen, P.W.T.C., Bauer, C., Munzel, M., Wagner, M., Müller, M., Khan, F., Eberl, H.C., Mensinga, A., Brinkman, A.B., Lephikov, K., Muller, U., Walter, J., Boelens, R., van Ingen, H., Leonhardt, H., Carell, T., Biomolecular Mass Spectrometry and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Sub NMR Spectroscopy

Publikováno v: Cell, 152, 1146. Cell Press
Cell, 152, 1146-1159
Cell, 152, 5, pp. 1146-1159

SummaryTet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases remains elusive. We applied quantitative mass-spectrometry-based pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ce269c0dad81b5dab5622c374dfb74
https://dspace.library.uu.nl/handle/1874/290517

Swapping Interface Contacts in the Homodimeric tRNA-Guanine Transglycosylase: An Option for Functional Regulation.

Autor: Ehrmann FR; Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032, Marburg, Germany., Kalim J; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland., Pfaffeneder T; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland., Bernet B; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland., Hohn C; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland., Schäfer E; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland., Botzanowski T; Laboratoire de Spectrométrie de Masse Bio-Organique, Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France., Cianférani S; Laboratoire de Spectrométrie de Masse Bio-Organique, Université de Strasbourg, CNRS, IPHC UMR 7178, 67000, Strasbourg, France., Heine A; Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032, Marburg, Germany., Reuter K; Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032, Marburg, Germany., Diederich F; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland., Klebe G; Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032, Marburg, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Aug 06; Vol. 57 (32), pp. 10085-10090. Date of Electronic Publication: 2018 Jul 16.

Qualitative and Quantitative Analytical Techniques of Nucleic Acid Modification Based on Mass Spectrometry for Biomarker Discovery.

Autor: Liu, Ying^1,2 (AUTHOR) zhouyl@pku.edu.cn, Dong, Jia-Hui¹ (AUTHOR), Shen, Xu-Yang¹ (AUTHOR), Gu, Yi-Xuan¹ (AUTHOR), Zhang, Run-Hong¹ (AUTHOR), Cui, Ruo-Yao¹ (AUTHOR), Liu, Ya-Hong¹ (AUTHOR), Zhou, Jiang^1,2 (AUTHOR) zhoujiang@pku.edu.cn, Zhou, Ying-Lin¹ (AUTHOR), Zhang, Xin-Xiang¹ (AUTHOR) zhoujiang@pku.edu.cn

Publikováno v: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 6, p3383. 19p.