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A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features.

Autor: Klughammer J; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. klughammer@genzentrum.lmu.de.; Gene Center and Department of Biochemistry, Ludwig Maximilians Universität München, Munich, Germany. klughammer@genzentrum.lmu.de., Abravanel DL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. daniel_abravanel@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. daniel_abravanel@dfci.harvard.edu., Segerstolpe Å; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Blosser TR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Goltsev Y; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Cui Y; Department of Media Arts and Sciences, McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Goodwin DR; Department of Media Arts and Sciences, McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Sinha A; Department of Media Arts and Sciences, McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Ashenberg O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Slyper M; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Vigneau S; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Jané-Valbuena J; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Alon S; Department of Media Arts and Sciences, McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; Faculty of Engineering, Gonda Brain Research Center and Institute of Nanotechnology, Bar-Ilan University, Ramat Gan, Israel., Caraccio C; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Chen J; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Cohen O; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Guiron University, Beersheba, Israel., Cullen N; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., DelloStritto LK; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Dionne D; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Files J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Frangieh A; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Helvie K; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Hughes ME; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Inga S; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Kanodia A; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Lako A; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., MacKichan C; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Mages S; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Gene Center and Department of Biochemistry, Ludwig Maximilians Universität München, Munich, Germany., Moriel N; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Murray E; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Napolitano S; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Nguyen K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Nitzan M; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.; Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem, Israel.; Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Ortiz R; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Patel M; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Pfaff KL; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Porter CBM; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Rotem A; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA.; AstraZeneca R&D, Boston, MA, USA., Strauss S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Strasser R; Gene Center and Department of Biochemistry, Ludwig Maximilians Universität München, Munich, Germany., Thorner AR; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Turner M; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA., Wakiro I; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Waldman J; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Wu J; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Gómez Tejeda Zañudo J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zhang D; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lin NU; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Tolaney SM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Winer EP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Boyden ES; Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA., Chen F; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Nolan GP; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Rodig SJ; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Zhuang X; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Department of Physics, Harvard University, Cambridge, MA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, Inc., South San Francisco, CA, USA., Johnson BE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Regev A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. regev.aviv@gene.com.; Genentech, Inc., South San Francisco, CA, USA. regev.aviv@gene.com., Wagle N; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. wagle.nikhil@gene.com.; Harvard Medical School, Boston, MA, USA. wagle.nikhil@gene.com.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA. wagle.nikhil@gene.com.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. wagle.nikhil@gene.com.; Genentech, Inc., South San Francisco, CA, USA. wagle.nikhil@gene.com.

Publikováno v: Nature medicine [Nat Med] 2024 Nov; Vol. 30 (11), pp. 3236-3249. Date of Electronic Publication: 2024 Oct 30.

Low PD-L1 expression, MAP2K2 alterations, and enriched HPV gene signatures characterize brain metastases in head and neck squamous cell carcinoma.

Autor: Dennis MJ; Center for Head & Neck Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Michael_dennis@dfci.harvard.edu.; Dana-Farber Cancer Institute, 450 Brookline Avenue, Dana Building, Room 2128, Boston, MA, 02215, USA. Michael_dennis@dfci.harvard.edu., Pavlick DC; Foundation Medicine Inc., Boston, MA, USA., Kacew A; Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA., Wotman M; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., MacConaill LE; Department of Pathology, Mass General Brigham, Boston, MA, USA., Jones SM; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Pfaff KL; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Rodig SJ; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Eacker S; Phase Genomics Inc., Seattle, WA, USA., Malig M; Phase Genomics Inc., Seattle, WA, USA., Reister E; Phase Genomics Inc., Seattle, WA, USA., Piccioni D; Moores Cancer Center, University of California San Diego Health, La Jolla, CA, USA., Kesari S; Pacific Neuroscience Institute, Santa Monica, CA, USA., Sehgal K; Center for Head & Neck Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Haddad RI; Center for Head & Neck Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Cohen E; Moores Cancer Center, University of California San Diego Health, La Jolla, CA, USA., Posner MR; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Deichaite I; University of California San Diego, La Jolla, CA, USA., Hanna GJ; Center for Head & Neck Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Publikováno v: Journal of translational medicine [J Transl Med] 2024 Oct 22; Vol. 22 (1), pp. 960. Date of Electronic Publication: 2024 Oct 22.