Virus-directed enzyme prodrug therapy using CB1954

Autor: Jane Grove, Pf, Searle, Sj, Weedon, Nk, Green, Ia, Mcneish, Dj, Kerr

Publikováno v: Europe PubMed Central

The virus-directed enzyme prodrug therapy (VDEPT) anti-cancer 'gene therapy' strategy relies on the use of viral vectors for the efficient delivery to tumour cells of a 'suicide gene' encoding an enzyme which converts a non-toxic prodrug to a cytotox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cb5fab3a979c4c3241162d22f04fbdb9
https://pubmed.ncbi.nlm.nih.gov/10834268

Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene

Autor: Nk, Green, Dj, Youngs, John Neoptolemos, Friedlos F, Rj, Knox, Cj, Springer, Gm, Anlezark, Np, Michael, Rg, Melton, Mj, Ford, Ls, Young, Dj, Kerr, Pf, Searle

Publikováno v: Europe PubMed Central

Expression of genes encoding prodrug-activating enzymes can increase the susceptibility of tumor cells to prodrugs, and may ultimately achieve a better therapeutic index than conventional chemotherapy. CB1954 is a weak, monofunctional alkylating agen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cc05eaf1c4392ea5f604f1e76548272a
https://pubmed.ncbi.nlm.nih.gov/9253508

Oxygen-insensitive nitroreductase E. coli NfsA, but not NfsB, is inhibited by fumarate.

Autor: Day MA; School of Biosciences, University of Birmingham, Birmingham, UK.; Institute for Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Jarrom D; School of Biosciences, University of Birmingham, Birmingham, UK., Rajah N; School of Biosciences, University of Birmingham, Birmingham, UK., Searle PF; Institute for Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Hyde EI; School of Biosciences, University of Birmingham, Birmingham, UK., White SA; School of Biosciences, University of Birmingham, Birmingham, UK.

Publikováno v: Proteins [Proteins] 2023 May; Vol. 91 (5), pp. 585-592. Date of Electronic Publication: 2022 Dec 13.

The 3D-structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP ⁺ provide glimpses of its catalytic mechanism.

Autor: White SA; School of Biosciences, University of Birmingham, UK., Christofferson AJ; School of Science, RMIT University, Melbourne, Australia., Grainger AI; School of Biosciences, University of Birmingham, UK., Day MA; School of Biosciences, University of Birmingham, UK.; Institute for Cancer and Genomic Sciences, University of Birmingham, UK., Jarrom D; School of Biosciences, University of Birmingham, UK., Graziano AE; School of Biosciences, University of Birmingham, UK., Searle PF; Institute for Cancer and Genomic Sciences, University of Birmingham, UK., Hyde EI; School of Biosciences, University of Birmingham, UK.

Publikováno v: FEBS letters [FEBS Lett] 2022 Sep; Vol. 596 (18), pp. 2425-2440. Date of Electronic Publication: 2022 Jul 13.

Human Leukocyte Antigen (HLA) A*1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma.

Autor: Zheng Y; School of Cancer Sciences, Cancer Immunology & Immunotherapy Centre (CIIC), University of Birmingham, Edgbaston, Birmingham, United Kingdom., Parsonage G; School of Cancer Sciences, Cancer Immunology & Immunotherapy Centre (CIIC), University of Birmingham, Edgbaston, Birmingham, United Kingdom., Zhuang X; School of Cancer Sciences, Cancer Immunology & Immunotherapy Centre (CIIC), University of Birmingham, Edgbaston, Birmingham, United Kingdom., Machado LR; School of Health, University of Northampton, Boughton Green Road, Northampton, United Kingdom., James CH; School of Cancer Sciences, Cancer Immunology & Immunotherapy Centre (CIIC), University of Birmingham, Edgbaston, Birmingham, United Kingdom., Salman A; School of Cancer Sciences, Cancer Immunology & Immunotherapy Centre (CIIC), University of Birmingham, Edgbaston, Birmingham, United Kingdom., Searle PF; School of Cancer Sciences, Cancer Immunology & Immunotherapy Centre (CIIC), University of Birmingham, Edgbaston, Birmingham, United Kingdom., Hui EP; Partner State Key Laboratory of Oncology in South China, Sir Y.K. Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, PR China., Chan AT; Partner State Key Laboratory of Oncology in South China, Sir Y.K. Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, PR China., Lee SP; School of Cancer Sciences, Cancer Immunology & Immunotherapy Centre (CIIC), University of Birmingham, Edgbaston, Birmingham, United Kingdom. s.p.lee@bham.ac.uk.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2015 Oct; Vol. 3 (10), pp. 1138-47. Date of Electronic Publication: 2015 Feb 24.