Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Peyton S. Metzel"'
Autor:
Steven Kleinman, Jaime Houghton, Larry J. Dumont, Robert Schuyler, James R. Murphy, Peyton S. Metzel, Rebecca Lippincott
Publikováno v:
Transfusion. 50:589-599
BACKGROUND: The PASSPORT study was an FDA-mandated surveillance of outdated 7-day apheresis platelets (APs) to assess the bacterial culture release test (RT) performance and the chance of transfusing APs containing viable bacteria compared to unteste
Autor:
Steven Kleinman, Louis M. Katz, Kay R. Gregory, F. Blaine Hollinger, Roger Y. Dodd, Peyton S. Metzel, Susan L. Stramer
Publikováno v:
Transfusion
BACKGROUND: Emerging infections have been identified as a continuing threat to human health. Many such infections are known to be transmissible by blood transfusion, while others have properties indicating this potential. There has been no comprehens
Autor:
Maureen G. Conlan, Edwin A. Burgstaler, Richard J. Benjamin, Ronald G. Strauss, Ritchard G. Cable, Peyton S. Metzel, Alvaro A. Pineda, Jeffrey McCullough, Lily Lin, Seth Porter
Publikováno v:
Transfusion. 46:562-571
Background A photochemical treatment (PCT) system has been developed to inactivate a broad spectrum of pathogens and white blood cells in platelet (PLT) products. The system comprises PLT additive solution (PAS III), amotosalen HCl, a compound adsorp
Autor:
Laurence Corash, Edward L. Snyder, Maureen G. Conlan, Peyton S. Metzel, George D. Cimino, Laurene L. Baril, Kathryn B. Davis, Donald H. Buchholz, Margaret Rheinschmidt, Thomas J. Raife, Lily Lin
Publikováno v:
Transfusion. 44:1732-1740
BACKGROUND: A photochemical treatment (PCT) method to inactivate pathogens in platelet concentrates has been developed. The system uses a psoralen, amotosalen HCl, coupled with ultraviolet A (UVA) illumination. STUDY DESIGN AND METHODS: Three sequent
Autor:
Lily Lin, Kent Dupuis, Barbara J. Molini, Sheila A. Lukehart, Peyton S. Metzel, Laurence Corash, Roberta Dikeman, Robert Lane
Publikováno v:
Transfusion. 44:1496-1504
BACKGROUND: Bacterial contamination of platelet (PLT) concentrates can result in transfusion-transmitted sepsis. A photochemical treatment (PCT) process with amotosalen HCl and long-wavelength ultraviolet light (UVA), which cross-links nucleic acids,
Autor:
Laurence Corash, Kristen A. Bernard, Lily Lin, Valérie Jauvin, Harvey J. Alter, Krishna K. Murthy, Peyton S. Metzel, Carl V. Hanson
Publikováno v:
Transfusion
BACKGROUND: Viral contamination of platelet (PLT) concentrates can result in transfusion-transmitted diseases. A photochemical treatment (PCT) process with amotosalen-HCl and long-wavelength ultraviolet light (UVA), which cross-links nucleic acids, w
Autor:
Laurence Corash, Jin Sying Lin, Jeffrey McCullough, Ronald G. Strauss, Steven Coutre, Peyton S. Metzel, Edward A. Stadtmauer, Frank Howard, David H. Vesole, Lily Lin, Maureen G. Conlan, Sherrill J. Slichter, Alvaro A. Pineda, Scott Murphy, Lawrence T. Goodnough, Ritchard G. Cable, Ileana Lopez-Plaza, Joy Fridey, Kathryn B. Davis, Antonis Koutsoukos, Donald H. Buchholz, Edward A. Snyder, Thomas J. Raife, Richard J. Benjamin
Publikováno v:
Blood. 104(5)
We report a transfusion trial of platelets photochemically treated for pathogen inactivation using the synthetic psoralen amotosalen HCl. Patients with thrombocytopenia were randomly assigned to receive either photochemically treated (PCT) or convent
Autor:
Stephane Marblie, Jean-Pierre Cazenave, Laurence Corash, Hans Gulliksson, Peyton S. Metzel, Georgine E. de Greef, Lily Lin, Per Ljungman, Bruno Lioure, Kathryn B. Davis, Veronique Mayaudon, Derwood Pamphilon, Harald Klüter, Don Buchholz, Jocelyne Flament, Hans Vermeij, M. C. Kappers-Klunne, M. Laforet, Dick J. van Rhenen, Maureen G. Conlan
Publikováno v:
Blood, 101, 2426-2433. American Society of Hematology
A nucleic acid-targeted photochemical treatment (PCT) using amotosalen HCl (S-59) and ultraviolet A (UVA) light was developed to inactivate viruses, bacteria, protozoa, and leukocytes in platelet components. We conducted a controlled, randomized, dou