Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Peyton J. Spreacker"'
Autor:
Peyton J. Spreacker, Nathan E. Thomas, Will F. Beeninga, Merissa Brousseau, Colin J. Porter, Kylie M. Hibbs, Katherine A. Henzler-Wildman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Antibiotic resistance through multidrug efflux is a major hurdle in antibiotic development. Here, authors experimentally demonstrate that EmrE, a small multidrug resistance efflux pump from E. coli, can confer resistance or susceptibility depending o
Externí odkaz:
https://doaj.org/article/78d3e70700c04c05bf5b159674cdf840
Autor:
Alexander A. Shcherbakov, Peyton J. Spreacker, Aurelio J. Dregni, Katherine A. Henzler-Wildman, Mei Hong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
EmrE transporter effluxes cationic substrates across lipid membranes in a pH-coupled manner. Here, the authors solve the structure of ligand-bound EmrE at high pH by NMR, with insights into the transport mechanism.
Externí odkaz:
https://doaj.org/article/a6ff24e0a3844b76b2840e90afda18df
Autor:
Peyton J. Spreacker, Colin J. Porter, Andrea Wegrzynowicz, Will F. Beeninga, Sydnye Demas, Emma N. Powers, Katherine A. Henzler-Wildman
Small multidrug resistance (SMR) transporters efflux toxic substrates from bacterial cells and were recently divided into two subfamilies: specific toxic metabolite transporters and promiscuous drug exporters. These drug exporters are thought to func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f0197d6bb622f81dd62566f2645fccb
https://doi.org/10.1101/2022.11.22.517605
https://doi.org/10.1101/2022.11.22.517605
Autor:
Peyton J. Spreacker, Merissa Brousseau, Grant S. Hisao, Mohammad Soltani, James H. Davis, Katherine A. Henzler-Wildman
Publikováno v:
The Journal of biological chemistry.
EmrE, a small multidrug resistance (SMR) transporter from E. coli, confers broad-spectrum resistance to polyaromatic cations and quaternary ammonium compounds. Previous transport assays demonstrate that EmrE transports a +1 and a +2 substrate with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc54862079ef6349cefd314957a56d7
https://pubmed.ncbi.nlm.nih.gov/36529287
https://pubmed.ncbi.nlm.nih.gov/36529287
Autor:
Peyton J. Spreacker, Merissa Brousseau, Grant S. Hisao, Mohammad Soltani, James H. Davis, Katherine A. Henzler-Wildman
EmrE, a small multidrug resistance (SMR) transporter from E. coli, confers broad-spectrum resistance to polyaromatic cations and quaternary ammonium compounds. Previous transport assays demonstrate that EmrE transports a +1 and a +2 substrate with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e45b99490bd2080b78a2de464f0489
https://doi.org/10.1101/2022.08.17.503475
https://doi.org/10.1101/2022.08.17.503475
Publikováno v:
Biophysical Journal. 122:400a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cd7ad57cf0b1be70cfad9f4600c4db2
https://doi.org/10.1016/j.bpj.2022.11.2182
https://doi.org/10.1016/j.bpj.2022.11.2182
Autor:
Alexander A, Shcherbakov, Peyton J, Spreacker, Aurelio J, Dregni, Katherine A, Henzler-Wildman, Mei, Hong
Publikováno v:
Nature communications. 13(1)
The homo-dimeric bacterial membrane protein EmrE effluxes polyaromatic cationic substrates in a proton-coupled manner to cause multidrug resistance. We recently determined the structure of substrate-bound EmrE in phospholipid bilayers by measuring hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b828ae65ce04c75f2cdb3f5526bbb4fd
https://pubmed.ncbi.nlm.nih.gov/35181664
https://pubmed.ncbi.nlm.nih.gov/35181664
Autor:
Will F Beeninga, Katherine A. Henzler-Wildman, Brooke L Young, Peyton J. Spreacker, Colin J Porter
Small multidrug resistance (SMR) transporters efflux toxic substrates from bacterial cells. These transporters were recently divided into two subfamilies: the GdX-like and EmrE-like SMRs. The EmrE-like subfamily of SMRs is predicted to contain transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e65313a68dfc68f8c62c0df2aa36563
https://doi.org/10.1101/2021.01.06.425668
https://doi.org/10.1101/2021.01.06.425668
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fea270bfac4478ecbf26ae1ebed8195c
https://doi.org/10.1096/fasebj.2019.33.1_supplement.779.2
https://doi.org/10.1096/fasebj.2019.33.1_supplement.779.2
Autor:
Christopher G. Tate, Nathan E. Thomas, Gregory T. DeKoster, Grant Hussey, Samantha A. Wynne, Chao Wu, Eva-Maria E. Uhlemann, Katherine A. Henzler-Wildman, Peyton J. Spreacker
Publikováno v:
Biophysical Journal. 118:2a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb49699bd30d5e6281ce32427afa91aa
https://doi.org/10.1016/j.bpj.2019.11.205
https://doi.org/10.1016/j.bpj.2019.11.205