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Neoadjuvant FOLFOXIRI prior to chemoradiotherapy for high-risk ('ugly') locally advanced rectal cancer: study protocol of a single-arm, multicentre, open-label, phase II trial (MEND-IT)

Autor: van den Berg, K., Schaap, D. P., Voogt, E. L. K., Buffart, T. E., Verheul, H. M. W., de Groot, J. W. B., Verhoef, C., Melenhorst, J., Roodhart, J. M. L., de Wilt, J. H. W., van Westreenen, H. L., Aalbers, A. G. J., van 't Veer, M., Marijnen, C. A. M., Vincent, J., Simkens, L. H. J., Peters, N. A. J. B., Berbée, M., Werter, I. M., Snaebjornsson, P., Peulen, H. M. U., van Lijnschoten, I. G., Roef, M. J., Nieuwenhuijzen, G. A. P., Bloemen, J. G., Willems, J. M. W. E., Creemers, G. J. M., Nederend, J., Rutten, H. J. T., Burger, J. W. A.

Publikováno v: BMC Cancer, 22(1):957. BioMed Central Ltd
BMC Cancer, 22(1):957. BioMed Central
BMC Cancer, 22
BMC Cancer, 22(1):957. BioMed Central Ltd.
BMC Cancer, 22, 1
van den Berg, K, Schaap, D P, Voogt, E L K, Buffart, T E, Verheul, H M W, de Groot, J W B, Verhoef, C, Melenhorst, J, Roodhart, J M L, de Wilt, J H W, van Westreenen, H L, Aalbers, A G J, van 't Veer, M, Marijnen, C A M, Vincent, J, Simkens, L H J, Peters, N A J B, Berbée, M, Werter, I M, Snaebjornsson, P, Peulen, H M U, van Lijnschoten, I G, Roef, M J, Nieuwenhuijzen, G A P, Bloemen, J G, Willems, J M W E, Creemers, G J M, Nederend, J, Rutten, H J T & Burger, J W A 2022, ' Neoadjuvant FOLFOXIRI prior to chemoradiotherapy for high-risk ("ugly") locally advanced rectal cancer : study protocol of a single-arm, multicentre, open-label, phase II trial (MEND-IT) ', BMC Cancer, vol. 22, no. 1, 957, pp. 957 . https://doi.org/10.1186/s12885-022-09947-w

Background The presence of mesorectal fascia (MRF) invasion, grade 4 extramural venous invasion (EMVI), tumour deposits (TD) or extensive or bilateral extramesorectal (lateral) lymph nodes (LLN) on MRI has been suggested to identify patients with ind

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