Can Glatiramer Acetate Prevent Cognitive Impairment by Modulating Oxidative Stress in Patients with Multiple Sclerosis?

Autor: Anna Gil-Sánchez, Hugo Gonzalo, Marc Canudes, Lara Nogueras, Cristina González-Mingot, Petya Valcheva, Pascual Torres, Jose Carlos Serrano, Silvia Peralta, Maria José Solana, Luis Brieva

Publikováno v: Pharmaceuticals, Vol 17, Iss 4, p 459 (2024)

Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and neuroinflammation, often accompanied by cognitive impairment. This study aims (1) to investigate the potential of glatiramer acetate (GA) as a therapy for preventing

Externí odkaz: https://doaj.org/article/92836b264816454bbfbd16e0ce0a24d0

Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition

Autor: Carlos Martínez-Salgado, Sara Panizo, Natalia Carrillo-López, Covadonga Quirós-Caso, Adriana S. Dusso, Jorge B. Cannata-Andía, Anna Cardus, Javier Rodríguez-Carrio, María José Motilva, Anabel L. Castro-Grattoni, Petya Valcheva, Catalina Ulloa, Carmen Rodriguez-Suarez, Maria Vittoria Arcidiacono, Laura Martínez-Arias

Publikováno v: Scientific Reports
Recercat. Dipósit de la Recerca de Catalunya
instname
RIUR. Repositorio Institucional de la Universidad de La Rioja
Repositorio Abierto de la UdL
Universitad de Lleida
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
Scipedia SL
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)

In chronic kidney disease (CKD), hyperphosphatemia-induced inflammation aggravates vascular calcification (VC) by increasing vascular smooth muscle cell (VSMC) osteogenic differentiation, ADAM17-induced renal and vascular injury, and TNFα-induction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724f8a2f6fc7e1ebff772130ab2b8017
https://investigacion.unirioja.es/documentos/5e695b492999522cccdd2e04

Lack of vitamin D receptor causes stress-induced premature senescence in vascular smooth muscle cells through enhanced local angiotensin-II signals

Autor: Petya Valcheva, Anna Cardús, Jose M. Valdivielso, Elvira Fernández, Jose Miguel López Novoa, Adriana Dusso, Milica Bozic, Eva Parisi, Sara Panizo

Publikováno v: Atherosclerosis. 235:247-255

Objectives The inhibition of the renal renin-angiotensin system by the active form of vitamin D contributes to the cardiovascular health benefits of a normal vitamin D status. Local production of angiotensin-II in the vascular wall is a potent mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05024062f331c6ac967100cc505a8fd7
https://doi.org/10.1016/j.atherosclerosis.2014.05.911

RANKL Increases Vascular Smooth Muscle Cell Calcification Through a RANK-BMP4–Dependent Pathway

Autor: Susana López-Ongil, Petya Valcheva, Jose M. Valdivielso, Mario Encinas, Anna Cardús, Blai Coll, Elvira Fernández, Eva Parisi, Sara Panizo

Publikováno v: Circulation Research. 104:1041-1048

Vascular calcification commonly associated with several pathologies and it has been suggested to be similar to bone mineralization. The axis RANKL-OPG (receptor activator of nuclear factor kappaB ligand-osteoprotegerin) finely controls bone turnover.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6eb0aa487a4df1b828a905eebc4cf2b
https://doi.org/10.1161/circresaha.108.189001

Sustained activation of renal N-methyl-D-aspartate receptors decreases vitamin D synthesis: a possible role for glutamate on the onset of secondary HPT

Autor: Milica Bozic, Sara Panizo, Petya Valcheva, Jose M. Valdivielso, Mercè Ibarz, Elvira Fernández, Blai Coll, Eva Parisi

Publikováno v: American journal of physiology. Endocrinology and metabolism. 299(5)

N-methyl-d-aspartate (NMDA) receptors (NMDAR) are tetrameric amino acid receptors that act as membrane calcium channels. The presence of the receptor has been detected in the principal organs responsible for calcium homeostasis (kidney, bone, and par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21b38d2a3497b86cd59221a20b86eea
https://pubmed.ncbi.nlm.nih.gov/20823451