Discovery of GlyT1 inhibitors with improved pharmacokinetic properties

Autor: Wolkenberg, Scott E., Zhao, Zhijian, Wisnoski, David D., Leister, William H., O’Brien, Julie, Lemaire, Wei, Williams, David L., Jr., Jacobson, Marlene A., Sur, Cyrille, Kinney, Gene G., Pettibone, Doug J., Tiller, Philip R., Smith, Sheri, Gibson, Christopher, Ma, Bennett K., Polsky-Fisher, Stacey L., Lindsley, Craig W., Hartman, George D.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 2009 19(5):1492-1495

Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA

Autor: Zhao, Zhijian, Wisnoski, David D., O’Brien, Julie A., Lemaire, Wei, Williams, David L., Jr., Jacobson, Marlene A., Wittman, Marion, Ha, Sookhee N., Schaffhauser, Herve, Sur, Cyrille, Pettibone, Doug J., Duggan, Mark E., Conn, P. Jeffrey, Hartman, George D., Lindsley, Craig W.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 2007 17(5):1386-1391

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

Autor: Lindsley CW; Department of Medicinal Chemistry, Technology Enabled Synthesis Group, Department of Neuroscience, Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. craig_lindsley@merck.com, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL Jr, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2004 Nov 18; Vol. 47 (24), pp. 5825-8.