UV–visible absorption spectroscopy for in-line API concentration measurement in nanoparticle production process using controlled expansion of supercritical solutions (CESS®)

Autor: Ari Kauppinen, Petteri Helander, Mikael Viitala, Tuomas Puranen, Tuomas Vainikka, Ilkka Lassila, Edward Hæggström, Niklas Sandler

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 224:115169

Most new small drug molecules in pharmaceutical development require improvement of solubility. The controlled expansion of supercritical solutions (CESS®) process is a nanoparticle production technology, dedicated to enhancing the dissolution rate o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1cf507b82d8736f0cd3df628a16cf6
https://doi.org/10.1016/j.jpba.2022.115169

Controlling oleogel crystallization using ultrasonic standing waves

Autor: Petteri Helander, Luisa Barba, Tuomas Puranen, Edward Hæggström, Ari Salmi, Oskari Tommiska, Jesse Heikkila, Fabio Valoppi, Miika Ratilainen

Publikováno v: Scientific Reports
Scientific reports (Nature Publishing Group) 10 (2020). doi:10.1038/s41598-020-71177-6
info:cnr-pdr/source/autori:Valoppi F.; Salmi A.; Ratilainen M.; Barba L.; Puranen T.; Tommiska O.; Helander P.; Heikkila J.; Haeggstrom E./titolo:Controlling oleogel crystallization using ultrasonic standing waves/doi:10.1038%2Fs41598-020-71177-6/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Oleogels are lipid-based soft materials composed of large fractions of oil (> 85%) developed as saturated and hydrogenated fat substitutes to reduce cardiovascular diseases caused by obesity. Promising oleogels are unstable during storage, and to imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f509251511f2cc237836f119b4487b
https://pubmed.ncbi.nlm.nih.gov/32879336

Simulating Acoustic Orientation Trapping for Stable Levitation

Autor: Antti Meriläinen, Tuomas Puranen, Karri Muinonen, Ivan Kassamakov, Antti Penttilä, Petteri Helander, Ari Salmi, Edward Haggstrom, Maria Gritsevich, Göran Maconi

Publikováno v: 2019 IEEE International Ultrasonics Symposium (IUS).

Acoustic levitation permits non-contact handling of mm-scale samples. To improve its applicability, we did a simulation study to optimize orientation control of a sample residing in a phased array levitator. The acoustic forces and torques on asymmet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126d7d6a79b9da72dd5549f44fe67a8e
https://doi.org/10.1109/ultsym.2019.8925843

Towards Chronic Wound Pads : Gradient Nanofiber Structure Generated by Ultrasound Enhanced Electrospinning (USES)

Autor: Petteri Helander, Joni Makinen, Ivo Laidmäe, Karin Kogermann, Anton Nolvi, Ari Salmi, Edward Haggstrom, Heikki J. Nieminen, Joel Hunnakko, Jyrki Heinämäki, Tuomas Puranen

We utilized an ultrasound enhanced electrospinning (USES) technique to produce a four-layer nanofiber scaffold. In contrast to ordinary electrospinning (ES), in the USES process, acoustic radiation pressure generates a cone at the free surface of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e407d3df9cfae32fba2b5514f0f315
http://hdl.handle.net/10138/322516

FEM Modelling of Ultrasound Enhanced Electrospinning (USES)

Autor: Edward Haggstrom, Petteri Helander, Ari Salmi, Jyrki Heinämäki, Heikki J. Nieminen, Joni Makinen, Karin Kogermann, Joel Hunnakko, Ivo Laidmäe, Tuomas Puranen

We present simulation efforts towards trying to understand ultrasound enhanced electrospinning (USES). Compared to traditional electrospinning this method uses ultrasound to produce an acoustic fountain on the free surface of the spinning liquid. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bade990be9ab79d8f319754325a278
http://hdl.handle.net/10138/326285