Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Petter Svanberg"'
Autor:
Jacob M. vanLaar, Alejhandra Lei, Mary Safy‐Khan, Joachim Almquist, Graham Belfield, Karl Edman, Lisa Öberg, Bastian R. Angermann, Inken Dillmann, Pia Berntsson, Damla Etal, Ian Dainty, Carol Astbury, Maria G. Belvisi, Szilárd Nemes, Adam Platt, Susanne Prothon, Sara Samuelsson, Petter Svanberg, Christina Keen, the SEMRA study group
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2494-2506 (2023)
Abstract Oral corticosteroid use is limited by side effects, some caused by off‐target actions on the mineralocorticoid receptor that disrupt electrolyte balance. AZD9567 is a selective, nonsteroidal glucocorticoid receptor modulator. The efficacy,
Externí odkaz:
https://doaj.org/article/a7401ac9a26c4a28953bd5b0830bee0b
Autor:
Anders Berggren, Rainard Fuhr, Carina Ämmälä, Susanne Prothon, Ramon Hendrickx, Matthew Dearman, Karl Edman, Jacob Leander, Eva-Marie Andersson, Christina Keen, Ziad Taib, Petter Svanberg, Joachim Almquist, Ulf Eriksson, Kicki A Johansson, Björn Carlsson, Mahdi Hashemi, Tove Hegelund Myrbäck, Goran Edenro
Publikováno v:
The Lancet Rheumatology. 2:e31-e41
Summary Background Glucocorticoids are highly effective and widely used anti-inflammatory drugs, but their use is limited by serious side-effects, including glucocorticoid-induced hyperglycaemia and diabetes. AZD9567 is a non-steroidal, selective glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6910ac88779631d7a1fd6735c831de
https://doi.org/10.1016/s2665-9913(19)30103-1
https://doi.org/10.1016/s2665-9913(19)30103-1
Autor:
Roine I. Olsson, Rikard Pehrson, Rongfeng Chen, Jesper Malmberg, Anna Malmberg, Nafizal Hossain, Hanna Grindebacke, Mia Collins, Matti Lepistö, Yao Xiong, Nina Krutrök, Antonio Llinas, Thomas Hansson, Eva L. Hansson, Elisabeth Bäck, Anna Aagaard, Jane McPheat, Linda Thunberg, Sarah Lever, Agnes Leffler, Yafeng Xue, Stefan von Berg, Petter Svanberg, Frank Narjes, Marie Ramnegård, Glyn Hughes, Johan Jirholt
Publikováno v:
Journal of medicinal chemistry. 64(18)
Inverse agonists of the nuclear receptor RORC2 have been widely pursued as a potential treatment for a variety of autoimmune diseases. We have discovered a novel series of isoindoline-based inverse agonists of the nuclear receptor RORC2, derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5abd65b9c67744ef1cfe77ef55392ba
https://pubmed.ncbi.nlm.nih.gov/34464130
https://pubmed.ncbi.nlm.nih.gov/34464130
Autor:
Taylor S. Cohen, Lisa Öberg, Nisha Kurian, Erica De Zan, Britta Bonn, Petter Svanberg, Engin Baturcam, Gabriel Skogberg, Paul D. Smith, Outi Vaarala, Danen Cunoosamy, Stefan Vollmer
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease. 14:2611-2624
Background Unlike p38 mitogen-activated protein Kinases (MAPK) that has been extensively studied in the context of lung-associated pathologies in COPD, the role of the dual-specificity mitogen-activated protein kinase kinase (MEK1/2) or its downstrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::238d5e211e55ca66ace0dbf2e462b1af
https://doi.org/10.2147/copd.s211619
https://doi.org/10.2147/copd.s211619
Autor:
Alejhandra Lei, Petter Svanberg, S. Samuelsson, C. Astbury, Christina Keen, Susanne Prothon, Maria G. Belvisi, Joachim Almquist, J.M. van Laar, Adam Platt, M. Safy-Khan
Publikováno v:
Annals of the Rheumatic Diseases. 80:253-254
Background:Oral corticosteroids such as prednisolone are potent anti-inflammatory drugs but their use is limited by side effects caused by unwanted actions on the glucocorticoid receptor (GR), such as increased insulin resistance, and off-target acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::156db222420c250675fb3942ed7ee88a
https://doi.org/10.1136/annrheumdis-2021-eular.632
https://doi.org/10.1136/annrheumdis-2021-eular.632
Autor:
Nisha, Kurian, Taylor S, Cohen, Lisa, Öberg, Erica, De Zan, Gabriel, Skogberg, Stefan, Vollmer, Engin, Baturcam, Petter, Svanberg, Britta, Bonn, Paul D, Smith, Outi, Vaarala, Danen M, Cunoosamy
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease
Background Unlike p38 mitogen-activated protein Kinases (MAPK) that has been extensively studied in the context of lung-associated pathologies in COPD, the role of the dual-specificity mitogen-activated protein kinase kinase (MEK1/2) or its downstrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67d1be01b08097773a85345fd5b55c2d
https://pubmed.ncbi.nlm.nih.gov/32063702
https://pubmed.ncbi.nlm.nih.gov/32063702
Autor:
Clive Brealey, Pär Nordell, Petter Svanberg, Wolfgang Kühn, Barry Jones, Marie Brännström, Ken Grime, Timothy Mant, Rikard Pehrson, Michael Gillen
Publikováno v:
British Journal of Clinical Pharmacology. 83:381-392
Aim AZD1981 is an orally bioavailable chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) receptor antagonist progressed to phase II trials for the treatment of allergic asthma. Previously performed in vitro human hepatocyte i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6a6c19719f2544adb8e8990d2bebc0a
https://doi.org/10.1111/bcp.13102
https://doi.org/10.1111/bcp.13102
Publikováno v:
Drug Metabolism and Disposition. 44:527-533
A key requirement in drug discovery is to accurately define intrinsic clearance (CL(int)) values of less than 1 µl/min/10(6) hepatocytes, which requires assays that allow for longer incubation time as a complement to suspended hepatocytes. This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c010f43900a0d0c03f0077d8f6f15e
https://doi.org/10.1124/dmd.115.067769
https://doi.org/10.1124/dmd.115.067769
Autor:
Elin Boger, Margareta Hammarlund-Udenaes, Pär Ewing, Petter Svanberg, Markus Fridén, Erica Bäckström, Anders Lundqvist
Publikováno v:
Journal of Pharmaceutical Sciences. 105:838-845
The challenge of defining the concentration of unbound drug at the lung target site after inhalation limits the possibility to optimize target exposure by compound design. In this study, a novel rat lung slice methodology has been developed and appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b223e338d846a0c846bee28d0dbed1
https://doi.org/10.1002/jps.24575
https://doi.org/10.1002/jps.24575
Autor:
Ulf Eriksson, Rainard Fuhr, Goran Edenro, Eva-Marie Andersson, Christina Keen, Kicki A Johansson, M. Kraan, Outi Vaarala, Ramon Hendrickx, G. de Miquel, Mahdi Hashemi, Z. Tahib, Thomas Körnicke, T. Hegelund Myrbäck, Björn Carlsson, Petter Svanberg, Matthew Dearman, Jacob Leander, Susanne Prothon, Karl Edman
Publikováno v:
Saturday, 16 JUNE 2018.
Background: AZD9567 is a novel oral selective glucocorticoid receptor modulator (SGRM) developed to have an improved safety profile versus prednisolone while maintaining efficacy. Objectives: To show clinical evidence of safety differentiation for AZ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a5ac034a3bb1bb6e48f25cf42dd8b04
https://doi.org/10.1136/annrheumdis-2018-eular.5451
https://doi.org/10.1136/annrheumdis-2018-eular.5451