Altered Cytokine Production in Mice Lacking P2X 7 Receptors

Autor: Perregaux, David G., Solle, Mike, Petrushova, Nina, Koller, Beverly H., Griffiths, Richard J., Stam, Ethan, Labasi, Jeff, Gabel, Christopher A.

The P2X(7) receptor (P2X(7)R) is an ATP-gated ion channel expressed by monocytes and macrophages. To directly address the role of this receptor in interleukin (IL)-1 beta post-translational processing, we have generated a P2X(7)R-deficient mouse line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ace7c8184473e464b5501a39b9d5dc54

Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response.

Autor: Labasi JM; Department of Antibacterials, Immunology, and Inflammation, Pfizer Global Research and Development, Pfizer Inc., Groton, CT 06340, USA., Petrushova N, Donovan C, McCurdy S, Lira P, Payette MM, Brissette W, Wicks JR, Audoly L, Gabel CA

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2002 Jun 15; Vol. 168 (12), pp. 6436-45.