AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5.

Autor: Salscheider SL; Institute for Biochemistry, University of Cologne, Cologne, Germany., Gerlich S; Institute for Biochemistry, University of Cologne, Cologne, Germany., Cabrera-Orefice A; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Peker E; Institute for Biochemistry, University of Cologne, Cologne, Germany., Rothemann RA; Institute for Biochemistry, University of Cologne, Cologne, Germany., Murschall LM; Institute for Biochemistry, University of Cologne, Cologne, Germany., Finger Y; Institute for Biochemistry, University of Cologne, Cologne, Germany., Szczepanowska K; Medical Faculty, Institute for Mitochondrial Diseases and Aging, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Ahmadi ZA; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Guerrero-Castillo S; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Erdogan A; Institute for Biochemistry, University of Cologne, Cologne, Germany., Becker M; Institute for Biochemistry, University of Cologne, Cologne, Germany., Ali M; Institute for Biochemistry, University of Cologne, Cologne, Germany., Habich M; Institute for Biochemistry, University of Cologne, Cologne, Germany., Petrungaro C; Institute for Biochemistry, University of Cologne, Cologne, Germany., Burdina N; Institute for Biochemistry, University of Cologne, Cologne, Germany., Schwarz G; Institute for Biochemistry, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine, University of Cologne, Cologne, Germany., Klußmann M; Institute for Biochemistry, University of Cologne, Cologne, Germany., Neundorf I; Institute for Biochemistry, University of Cologne, Cologne, Germany., Stroud DA; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Vic., Australia., Ryan MT; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Vic., Australia., Trifunovic A; Medical Faculty, Institute for Mitochondrial Diseases and Aging, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine, University of Cologne, Cologne, Germany., Brandt U; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Riemer J; Institute for Biochemistry, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Publikováno v: The EMBO journal [EMBO J] 2022 Sep 01; Vol. 41 (17), pp. e110784. Date of Electronic Publication: 2022 Jul 20.

Interaction with the cysteine-free protein HAX1 expands the substrate specificity and function of MIA40 beyond protein oxidation.

Autor: Rothemann RA; Redox Metabolism, Institute of Biochemistry, University of Cologne, Germany., Stobbe D; Redox Metabolism, Institute of Biochemistry, University of Cologne, Germany., Hoehne-Wiechmann MN; Redox Metabolism, Institute of Biochemistry, University of Cologne, Germany., Murschall LM; Redox Metabolism, Institute of Biochemistry, University of Cologne, Germany., Peker E; Redox Metabolism, Institute of Biochemistry, University of Cologne, Germany., Knaup LK; Cellular Biochemistry, Institute of Biochemistry, University of Cologne, Germany., Racho J; Redox Metabolism, Institute of Biochemistry, University of Cologne, Germany., Habich M; Redox Metabolism, Institute of Biochemistry, University of Cologne, Germany., Gerlich S; Redox Metabolism, Institute of Biochemistry, University of Cologne, Germany., Lapacz KJ; Redox Metabolism, Institute of Biochemistry, University of Cologne, Germany., Ulrich K; Cellular Biochemistry, Institute of Biochemistry, University of Cologne, Germany., Riemer J; Redox Metabolism, Institute of Biochemistry, University of Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Germany.

Publikováno v: The FEBS journal [FEBS J] 2024 Dec; Vol. 291 (24), pp. 5506-5522. Date of Electronic Publication: 2024 Nov 20.

Vectorial Import via a Metastable Disulfide-Linked Complex Allows for a Quality Control Step and Import by the Mitochondrial Disulfide Relay.

Autor: Habich M; Institute for Biochemistry, Department of Chemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany., Salscheider SL; Institute for Biochemistry, Department of Chemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany., Murschall LM; Institute for Biochemistry, Department of Chemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany., Hoehne MN; Institute for Biochemistry, Department of Chemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany., Fischer M; Institute for Biochemistry, Department of Chemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany., Schorn F; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) and Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, CECAD Research Center, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany., Petrungaro C; Institute for Biochemistry, Department of Chemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany., Ali M; Institute for Biochemistry, Department of Chemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany., Erdogan AJ; Institute for Biochemistry, Department of Chemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany., Abou-Eid S; Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland., Kashkar H; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) and Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, CECAD Research Center, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany., Dengjel J; Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland., Riemer J; Institute for Biochemistry, Department of Chemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany. Electronic address: jan.riemer@uni-koeln.de.

Publikováno v: Cell reports [Cell Rep] 2019 Jan 15; Vol. 26 (3), pp. 759-774.e5.

The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo.

Autor: Erdogan AJ; Department of Chemistry, Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47a, 50674 Cologne, Germany., Ali M; Department of Chemistry, Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47a, 50674 Cologne, Germany; Department of Biology, Cellular Biochemistry, University of Kaiserslautern, Erwin-Schroedinger-Str. 13, 67663 Kaiserslautern, Germany., Habich M; Department of Chemistry, Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47a, 50674 Cologne, Germany., Salscheider SL; Department of Chemistry, Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47a, 50674 Cologne, Germany., Schu L; Department of Biology, Cellular Biochemistry, University of Kaiserslautern, Erwin-Schroedinger-Str. 13, 67663 Kaiserslautern, Germany., Petrungaro C; Department of Chemistry, Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47a, 50674 Cologne, Germany., Thomas LW; Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Ashcroft M; Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Leichert LI; Institute for Biochemistry and Pathobiochemistry - Microbial Biochemistry, Ruhr-Universität Bochum, 44797 Bochum, Germany., Roma LP; Biophysics Department, Center for Integrative Physiology and Molecular Medicine, Saarland University, 66421 Homburg, Saar, Germany., Riemer J; Department of Chemistry, Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47a, 50674 Cologne, Germany. Electronic address: jan.riemer@uni-koeln.de.

Publikováno v: Redox biology [Redox Biol] 2018 Jul; Vol. 17, pp. 200-206. Date of Electronic Publication: 2018 Mar 24.

The Interaction and Effect of a Small MitoBlock Library as Inhibitor of ALR Protein–Protein Interaction Pathway.

Autor: Muzzioli, Riccardo¹ (AUTHOR), Gallo, Angelo¹ (AUTHOR) angelo.gallo@unito.it

Publikováno v: International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 2, p1174. 14p.